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[Association of the C3 gene polymorphisms with susceptibility to adult asthma].

Abstract

OBJECTIVE

To investigate the association between single nucleotide polymorphisms (SNPs) of the complement component 3 gene (C3) and adult asthma of Hans in southern China.

METHODS

A case-control study was performed. Four hundred and eighty-four adult asthma patients diagnosed in Nanfang Hospital and Affiliated Hospital of Guangdong Medical College, and 553 healthy subjects were collected from 2006 to 2010 for the study. MassARRAY-IPLEX and matrix-assisted laser desorption/ionization time of flight mass spectrometry (MALDI-TOF-MS) techniques was used to determine the genotypes of the rs10402876 and rs366510 loci of C3 gene.

RESULTS

Genotypes GG, GT and TT in the rs366510 locus, and genotypes GG, GT and TT in the rs10402876 locus were detected. A total of 98.94 percent of samples were genotyped. There were no significant differences in genotype frequencies (chi-square =0.346,P=0.841) and allele frequencies (chi-square =0.101,P=0.751) of rs10402876 between the two groups. However, genotype and allele frequencies of the rs366510 locus were significantly different (chi-square =9.759, P=0.008, Bonferroni correction, P=0.016; chi-square =5.294,P=0.021, Bonferroni correction, P=0.042, respectively). Compared with genotypes GG+GT, genotype TT of rs366510 significantly increased the risk of asthma, with the odds ratio of 1.471 (95% confidence interval 1.125-1.923).

CONCLUSION

These results suggest that C3 gene could be associated with adult asthma of Han population in southern China.

Authors+Show Affiliations

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Intensive Care Unit of Zhongshan Bo Ai Hospital, Southern Medical University, Zhongshan, Guangdong, 528403 P. R. China. 28242174@qq.com

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Source

MeSH

Adult
Asthma
Case-Control Studies
China
Complement C3
Female
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Polymorphism, Single Nucleotide

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't

Language

chi

PubMed ID

21462136