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Development and psychometric evaluation of 2 age-stratified versions of the Pediatric GERD Symptom and Quality of Life Questionnaire.
J Pediatr Gastroenterol Nutr. 2011 May; 52(5):514-22.JP

Abstract

OBJECTIVES

The Pediatric Gastroesophageal Reflux Disease Symptom and Quality of Life Questionnaire (PGSQ) represents 2 related age-stratified tools developed to assess pediatric gastroesophageal reflux disease (GERD). These include the PGSQ-Cp (for children ages 2 to 8 years, parent/caregiver report) and the PGSQ-A (for adolescents ages 9-17 years). The objective of the present study was to develop and evaluate PGSQ measurement properties.

MATERIALS AND METHODS

The PGSQ items were generated based on information from focus groups, expert clinician review, and cognitive debriefing interviews. The symptoms of pediatric GERD and the effect of these symptoms were addressed. The tools were evaluated in a 3-week psychometric evaluation with participants from 11 clinical sites in the United States. The study included other measures such as the Pediatric Quality of Life questionnaire (PedsQL) and clinician-rated GERD severity. After item reduction, internal consistency, reproducibility, construct validity, known-group validity, and responsiveness were assessed.

RESULTS

The 231 participants included 75 parents of children ages 2 to 8 years and 75 children ages 9 to 17 years with GERD and 41 parents of children and 40 children ages 9 to 17 years without GERD. Exploratory factor analysis demonstrated 4 symptom subscales for the PGSQ-Cp and 3 symptom subscales for the PGSQ-A. Both had subscales for total impact and school impact. High to moderate internal consistency was observed, ranging from 0.76 to 0.96 for the PGSQ-Cp and from 0.67 to 0.94 for the PGSQ-A. The PGSQ significantly differentiated between patients with GERD and controls (P < 0.0001, PGSQ-Cp; P < 0.0022-0.0001, PGSQ-A) and demonstrated responsiveness.

CONCLUSIONS

These results support the reliability, validity, and responsiveness of both versions of the PGSQ. The instruments should be useful for clinical studies.

Authors+Show Affiliations

United BioSource Corporation, Bethesda, MD 20814, USA. leah.kleinman@unitedbiosource.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article
Validation Study

Language

eng

PubMed ID

21464757

Citation

Kleinman, Leah, et al. "Development and Psychometric Evaluation of 2 Age-stratified Versions of the Pediatric GERD Symptom and Quality of Life Questionnaire." Journal of Pediatric Gastroenterology and Nutrition, vol. 52, no. 5, 2011, pp. 514-22.
Kleinman L, Nelson S, Kothari-Talwar S, et al. Development and psychometric evaluation of 2 age-stratified versions of the Pediatric GERD Symptom and Quality of Life Questionnaire. J Pediatr Gastroenterol Nutr. 2011;52(5):514-22.
Kleinman, L., Nelson, S., Kothari-Talwar, S., Roberts, L., Orenstein, S. R., Mody, R. R., Hassall, E., Gold, B., Revicki, D. A., & Dabbous, O. (2011). Development and psychometric evaluation of 2 age-stratified versions of the Pediatric GERD Symptom and Quality of Life Questionnaire. Journal of Pediatric Gastroenterology and Nutrition, 52(5), 514-22. https://doi.org/10.1097/MPG.0b013e318205970e
Kleinman L, et al. Development and Psychometric Evaluation of 2 Age-stratified Versions of the Pediatric GERD Symptom and Quality of Life Questionnaire. J Pediatr Gastroenterol Nutr. 2011;52(5):514-22. PubMed PMID: 21464757.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Development and psychometric evaluation of 2 age-stratified versions of the Pediatric GERD Symptom and Quality of Life Questionnaire. AU - Kleinman,Leah, AU - Nelson,Suzanne, AU - Kothari-Talwar,Smita, AU - Roberts,Laurie, AU - Orenstein,Susan R, AU - Mody,Reema R, AU - Hassall,Eric, AU - Gold,Ben, AU - Revicki,Dennis A, AU - Dabbous,Omar, PY - 2011/4/6/entrez PY - 2011/4/6/pubmed PY - 2011/12/13/medline SP - 514 EP - 22 JF - Journal of pediatric gastroenterology and nutrition JO - J Pediatr Gastroenterol Nutr VL - 52 IS - 5 N2 - OBJECTIVES: The Pediatric Gastroesophageal Reflux Disease Symptom and Quality of Life Questionnaire (PGSQ) represents 2 related age-stratified tools developed to assess pediatric gastroesophageal reflux disease (GERD). These include the PGSQ-Cp (for children ages 2 to 8 years, parent/caregiver report) and the PGSQ-A (for adolescents ages 9-17 years). The objective of the present study was to develop and evaluate PGSQ measurement properties. MATERIALS AND METHODS: The PGSQ items were generated based on information from focus groups, expert clinician review, and cognitive debriefing interviews. The symptoms of pediatric GERD and the effect of these symptoms were addressed. The tools were evaluated in a 3-week psychometric evaluation with participants from 11 clinical sites in the United States. The study included other measures such as the Pediatric Quality of Life questionnaire (PedsQL) and clinician-rated GERD severity. After item reduction, internal consistency, reproducibility, construct validity, known-group validity, and responsiveness were assessed. RESULTS: The 231 participants included 75 parents of children ages 2 to 8 years and 75 children ages 9 to 17 years with GERD and 41 parents of children and 40 children ages 9 to 17 years without GERD. Exploratory factor analysis demonstrated 4 symptom subscales for the PGSQ-Cp and 3 symptom subscales for the PGSQ-A. Both had subscales for total impact and school impact. High to moderate internal consistency was observed, ranging from 0.76 to 0.96 for the PGSQ-Cp and from 0.67 to 0.94 for the PGSQ-A. The PGSQ significantly differentiated between patients with GERD and controls (P < 0.0001, PGSQ-Cp; P < 0.0022-0.0001, PGSQ-A) and demonstrated responsiveness. CONCLUSIONS: These results support the reliability, validity, and responsiveness of both versions of the PGSQ. The instruments should be useful for clinical studies. SN - 1536-4801 UR - https://www.unboundmedicine.com/medline/citation/21464757/Development_and_psychometric_evaluation_of_2_age_stratified_versions_of_the_Pediatric_GERD_Symptom_and_Quality_of_Life_Questionnaire_ L2 - https://doi.org/10.1097/MPG.0b013e318205970e DB - PRIME DP - Unbound Medicine ER -