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L-Carnitine induces recovery of liver lipid metabolism in cancer cachexia.
Amino Acids. 2012 May; 42(5):1783-92.AA

Abstract

Cancer cachexia causes metabolic alterations with a marked effect on hepatic lipid metabolism. L-Carnitine modulates lipid metabolism and its supplementation has been proposed as a therapeutic strategy in many diseases. In the present study, the effects of L-carnitine supplementation on gene expression and on liver lipid metabolism-related proteins was investigated in cachectic tumour-bearing rats. Wistar rats were assigned to receive 1 g/kg of L-carnitine or saline. After 14 days, supplemented and control animals were assigned to a control (N), control supplemented with L-carnitine (CN), tumour-bearing Walker 256 carcinosarcoma (TB) and tumour-bearing supplemented with L-carnitine (CTB) group. The mRNA expression of carnitine palmitoyltransferase I and II (CPT I and II), microsomal triglyceride transfer protein (MTP), liver fatty acid-binding protein (L-FABP), fatty acid translocase (FAT/CD36), peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and organic cation transporter 2 (OCTN2) was assessed, and the maximal activity of CPT I and II in the liver measured, along with plasma and liver triacylglycerol content. The gene expression of MTP, and CPT I catalytic activity were reduced in TB, who also showed increased liver (150%) and plasma (3.3-fold) triacylglycerol content. L-Carnitine supplementation was able to restore these parameters back to control values (p<0.05). These data show that L-carnitine preserves hepatic lipid metabolism in tumour-bearing animals, suggesting its supplementation to be of potential interest in cachexia.

Authors+Show Affiliations

Cancer Metabolism Research Group, Institute of Biomedical Sciences, University of São Paulo, Av. Prof. Lineu Prestes, 1524, CEP 05508-900, Butantã, São Paulo, SP, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21465256

Citation

Silvério, Renata, et al. "L-Carnitine Induces Recovery of Liver Lipid Metabolism in Cancer Cachexia." Amino Acids, vol. 42, no. 5, 2012, pp. 1783-92.
Silvério R, Laviano A, Rossi Fanelli F, et al. L-Carnitine induces recovery of liver lipid metabolism in cancer cachexia. Amino Acids. 2012;42(5):1783-92.
Silvério, R., Laviano, A., Rossi Fanelli, F., & Seelaender, M. (2012). L-Carnitine induces recovery of liver lipid metabolism in cancer cachexia. Amino Acids, 42(5), 1783-92. https://doi.org/10.1007/s00726-011-0898-y
Silvério R, et al. L-Carnitine Induces Recovery of Liver Lipid Metabolism in Cancer Cachexia. Amino Acids. 2012;42(5):1783-92. PubMed PMID: 21465256.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - L-Carnitine induces recovery of liver lipid metabolism in cancer cachexia. AU - Silvério,Renata, AU - Laviano,Alessandro, AU - Rossi Fanelli,Filippo, AU - Seelaender,Marília, Y1 - 2011/04/05/ PY - 2011/02/05/received PY - 2011/03/22/accepted PY - 2011/4/6/entrez PY - 2011/4/6/pubmed PY - 2012/10/2/medline SP - 1783 EP - 92 JF - Amino acids JO - Amino Acids VL - 42 IS - 5 N2 - Cancer cachexia causes metabolic alterations with a marked effect on hepatic lipid metabolism. L-Carnitine modulates lipid metabolism and its supplementation has been proposed as a therapeutic strategy in many diseases. In the present study, the effects of L-carnitine supplementation on gene expression and on liver lipid metabolism-related proteins was investigated in cachectic tumour-bearing rats. Wistar rats were assigned to receive 1 g/kg of L-carnitine or saline. After 14 days, supplemented and control animals were assigned to a control (N), control supplemented with L-carnitine (CN), tumour-bearing Walker 256 carcinosarcoma (TB) and tumour-bearing supplemented with L-carnitine (CTB) group. The mRNA expression of carnitine palmitoyltransferase I and II (CPT I and II), microsomal triglyceride transfer protein (MTP), liver fatty acid-binding protein (L-FABP), fatty acid translocase (FAT/CD36), peroxisome proliferator-activated receptor-alpha (PPAR-alpha) and organic cation transporter 2 (OCTN2) was assessed, and the maximal activity of CPT I and II in the liver measured, along with plasma and liver triacylglycerol content. The gene expression of MTP, and CPT I catalytic activity were reduced in TB, who also showed increased liver (150%) and plasma (3.3-fold) triacylglycerol content. L-Carnitine supplementation was able to restore these parameters back to control values (p<0.05). These data show that L-carnitine preserves hepatic lipid metabolism in tumour-bearing animals, suggesting its supplementation to be of potential interest in cachexia. SN - 1438-2199 UR - https://www.unboundmedicine.com/medline/citation/21465256/L_Carnitine_induces_recovery_of_liver_lipid_metabolism_in_cancer_cachexia_ L2 - https://dx.doi.org/10.1007/s00726-011-0898-y DB - PRIME DP - Unbound Medicine ER -