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PPAR-gamma agonist rosiglitazone attenuates the inflammation caused by carrageenan in the mouse model of pleurisy.
Inflammation. 2012 Feb; 35(1):280-8.I

Abstract

The aim of this study was to investigate the anti-inflammatory efficacy of rosiglitazone (ROSI) in a pleurisy model of carrageenan-induced inflammation. Efficacy was monitored in the mouse pleural cavity by evaluating leukocyte migration, exudate concentration, and myeloperoxidase (MPO) and adenosine deaminase (ADA) activities concomitantly with nitrate/nitrite (NOx), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-17A (IL-17A), and vascular endothelial growth factor-alpha (VEGF-α) levels 4 and 48 h after pleurisy induction. In both phases (4 and 48 h) of pleurisy, ROSI inhibited all the inflammation parameters that were tested (p<0.05). These results provide evidence that ROSI was efficacious in inhibiting pro-inflammatory mediators. These anti-inflammatory effects are assumed to mainly result from the inhibition of products released from activated leukocytes, such as MPO, ADA, NOx, TNF-α, IL-1β, IL-17A, and VEGF-α.

Authors+Show Affiliations

Department of Clinical Analysis, Center of Health Sciences, Federal University of Santa Catarina, Florianopolis, Santa Catarina, Brazil.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21465278

Citation

Buss, Ziliani da Silva, et al. "PPAR-gamma Agonist Rosiglitazone Attenuates the Inflammation Caused By Carrageenan in the Mouse Model of Pleurisy." Inflammation, vol. 35, no. 1, 2012, pp. 280-8.
Buss Zda S, Medeiros YS, Fröde TS. PPAR-gamma agonist rosiglitazone attenuates the inflammation caused by carrageenan in the mouse model of pleurisy. Inflammation. 2012;35(1):280-8.
Buss, Z. d. a. . S., Medeiros, Y. S., & Fröde, T. S. (2012). PPAR-gamma agonist rosiglitazone attenuates the inflammation caused by carrageenan in the mouse model of pleurisy. Inflammation, 35(1), 280-8. https://doi.org/10.1007/s10753-011-9316-6
Buss Zda S, Medeiros YS, Fröde TS. PPAR-gamma Agonist Rosiglitazone Attenuates the Inflammation Caused By Carrageenan in the Mouse Model of Pleurisy. Inflammation. 2012;35(1):280-8. PubMed PMID: 21465278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PPAR-gamma agonist rosiglitazone attenuates the inflammation caused by carrageenan in the mouse model of pleurisy. AU - Buss,Ziliani da Silva, AU - Medeiros,Yara S, AU - Fröde,Tania S, PY - 2011/4/6/entrez PY - 2011/4/6/pubmed PY - 2012/8/1/medline SP - 280 EP - 8 JF - Inflammation JO - Inflammation VL - 35 IS - 1 N2 - The aim of this study was to investigate the anti-inflammatory efficacy of rosiglitazone (ROSI) in a pleurisy model of carrageenan-induced inflammation. Efficacy was monitored in the mouse pleural cavity by evaluating leukocyte migration, exudate concentration, and myeloperoxidase (MPO) and adenosine deaminase (ADA) activities concomitantly with nitrate/nitrite (NOx), tumor necrosis factor-alpha (TNF-α), interleukin-1 beta (IL-1β), interleukin-17A (IL-17A), and vascular endothelial growth factor-alpha (VEGF-α) levels 4 and 48 h after pleurisy induction. In both phases (4 and 48 h) of pleurisy, ROSI inhibited all the inflammation parameters that were tested (p<0.05). These results provide evidence that ROSI was efficacious in inhibiting pro-inflammatory mediators. These anti-inflammatory effects are assumed to mainly result from the inhibition of products released from activated leukocytes, such as MPO, ADA, NOx, TNF-α, IL-1β, IL-17A, and VEGF-α. SN - 1573-2576 UR - https://www.unboundmedicine.com/medline/citation/21465278/PPAR_gamma_agonist_rosiglitazone_attenuates_the_inflammation_caused_by_carrageenan_in_the_mouse_model_of_pleurisy_ L2 - https://doi.org/10.1007/s10753-011-9316-6 DB - PRIME DP - Unbound Medicine ER -