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Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism.
Cell Biochem Funct. 2011 Apr; 29(3):235-43.CB

Abstract

The present study investigated whether the antioxidant activity of p,p'-methoxyl-diphenyl diselenide [(MeOPhSe)(2)] is involved in its protective effect against cognitive impairment induced by streptozotocin (STZ) in a model of sporadic dementia of Alzheimer's type (SDAT). Swiss mice were treated with STZ or vehicle [2 µl of 2·5 mg ml(-1) solution; intracerebroventricularly (i.c.v.)] twice, 48 h apart. (MeOPhSe)(2) (25 mg kg(-1)) or vehicle was orally administered 30 min prior to each STZ treatment. Neuroprotector effect of (MeOPhSe)(2) on the behavioral performance of mice on spatial recognition memory consolidation was investigated in the Y-maze test. After that, mouse brains were removed for measuring antioxidant parameters. (MeOPhSe)(2) protected against the impairment in learning and memory caused by i.c.v. administration of STZ in mice. (MeOPhSe)(2) protected against the increase in reactive species and the reduction of glutathione levels, as well as, the increase in superoxide dismutase and glutathione S-transferase activities caused by STZ in whole brain. These results suggest that antioxidant property is involved, at least in part, in the neuroprotective effect of (MeOPhSe)(2) on SDAT induced by STZ in mice.

Authors+Show Affiliations

Departamento de Química, Centro de Ciências Naturais e Exatas, Universidade Federal de Santa Maria, RS, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21465495

Citation

Pinton, Simone, et al. "Neuroprotector Effect of P,p'-methoxyl-diphenyl Diselenide in a Model of Sporadic Dementia of Alzheimer's Type in Mice: Contribution of Antioxidant Mechanism." Cell Biochemistry and Function, vol. 29, no. 3, 2011, pp. 235-43.
Pinton S, da Rocha JT, Gai BM, et al. Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism. Cell Biochem Funct. 2011;29(3):235-43.
Pinton, S., da Rocha, J. T., Gai, B. M., Prigol, M., da Rosa, L. V., & Nogueira, C. W. (2011). Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism. Cell Biochemistry and Function, 29(3), 235-43. https://doi.org/10.1002/cbf.1741
Pinton S, et al. Neuroprotector Effect of P,p'-methoxyl-diphenyl Diselenide in a Model of Sporadic Dementia of Alzheimer's Type in Mice: Contribution of Antioxidant Mechanism. Cell Biochem Funct. 2011;29(3):235-43. PubMed PMID: 21465495.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neuroprotector effect of p,p'-methoxyl-diphenyl diselenide in a model of sporadic dementia of Alzheimer's type in mice: contribution of antioxidant mechanism. AU - Pinton,Simone, AU - da Rocha,Juliana Trevisan, AU - Gai,Bibiana Mozzaquatro, AU - Prigol,Marina, AU - da Rosa,Luiz Vinícius, AU - Nogueira,Cristina Wayne, Y1 - 2011/02/24/ PY - 2010/11/17/received PY - 2010/12/28/revised PY - 2011/01/25/accepted PY - 2011/4/6/entrez PY - 2011/4/6/pubmed PY - 2011/8/10/medline SP - 235 EP - 43 JF - Cell biochemistry and function JO - Cell Biochem Funct VL - 29 IS - 3 N2 - The present study investigated whether the antioxidant activity of p,p'-methoxyl-diphenyl diselenide [(MeOPhSe)(2)] is involved in its protective effect against cognitive impairment induced by streptozotocin (STZ) in a model of sporadic dementia of Alzheimer's type (SDAT). Swiss mice were treated with STZ or vehicle [2 µl of 2·5 mg ml(-1) solution; intracerebroventricularly (i.c.v.)] twice, 48 h apart. (MeOPhSe)(2) (25 mg kg(-1)) or vehicle was orally administered 30 min prior to each STZ treatment. Neuroprotector effect of (MeOPhSe)(2) on the behavioral performance of mice on spatial recognition memory consolidation was investigated in the Y-maze test. After that, mouse brains were removed for measuring antioxidant parameters. (MeOPhSe)(2) protected against the impairment in learning and memory caused by i.c.v. administration of STZ in mice. (MeOPhSe)(2) protected against the increase in reactive species and the reduction of glutathione levels, as well as, the increase in superoxide dismutase and glutathione S-transferase activities caused by STZ in whole brain. These results suggest that antioxidant property is involved, at least in part, in the neuroprotective effect of (MeOPhSe)(2) on SDAT induced by STZ in mice. SN - 1099-0844 UR - https://www.unboundmedicine.com/medline/citation/21465495/Neuroprotector_effect_of_pp'_methoxyl_diphenyl_diselenide_in_a_model_of_sporadic_dementia_of_Alzheimer's_type_in_mice:_contribution_of_antioxidant_mechanism_ DB - PRIME DP - Unbound Medicine ER -