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Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation.
Pigment Cell Melanoma Res. 2011 Jun; 24(3):401-10.PC

Abstract

Most mammals are coated with pigmented hair. Melanocytes in each hair follicle produce melanin pigments for the hair during each hair cycle. The key to understanding the mechanism of cyclic melanin production is the melanocyte stem cell (MelSC) population, previously known as 'amelanotic melanocytes'. The MelSCs directly adhere to hair follicle stem cells, the niche cells for MelSCs and reside in the hair follicle bulge-subbulge area, the lower permanent portion of the hair follicle, to serve as a melanocyte reservoir for skin and hair pigmentation. MelSCs form a stem cell system within individual hair follicles and provide a 'hair pigmentary unit' for each cycle of hair pigmentation. This review focuses on the identification of MelSCs and their characteristics and explains the importance of the MelSC population in the mechanisms of hair pigmentation, hair greying, and skin repigmentation.

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Authors+Show Affiliations

Nishimura EK
Department of Stem Cell Biology, Medical Research Institute, Tokyo Medical and Dental University, Chiyoda-ku, Tokyo, Japan. nishscm@tmd.ac.jp

MeSH

AnimalsHair FollicleHumansMelaninsMelanocytesMiceSkin PigmentationStem Cells

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21466661

Citation

Nishimura, Emi K.. "Melanocyte Stem Cells: a Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation." Pigment Cell & Melanoma Research, vol. 24, no. 3, 2011, pp. 401-10.
Nishimura EK. Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation. Pigment Cell Melanoma Res. 2011;24(3):401-10.
Nishimura, E. K. (2011). Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation. Pigment Cell & Melanoma Research, 24(3), 401-10. https://doi.org/10.1111/j.1755-148X.2011.00855.x
Nishimura EK. Melanocyte Stem Cells: a Melanocyte Reservoir in Hair Follicles for Hair and Skin Pigmentation. Pigment Cell Melanoma Res. 2011;24(3):401-10. PubMed PMID: 21466661.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Melanocyte stem cells: a melanocyte reservoir in hair follicles for hair and skin pigmentation. A1 - Nishimura,Emi K, Y1 - 2011/05/05/ PY - 2011/4/7/entrez PY - 2011/4/7/pubmed PY - 2011/8/23/medline SP - 401 EP - 10 JF - Pigment cell & melanoma research JO - Pigment Cell Melanoma Res VL - 24 IS - 3 N2 - Most mammals are coated with pigmented hair. Melanocytes in each hair follicle produce melanin pigments for the hair during each hair cycle. The key to understanding the mechanism of cyclic melanin production is the melanocyte stem cell (MelSC) population, previously known as 'amelanotic melanocytes'. The MelSCs directly adhere to hair follicle stem cells, the niche cells for MelSCs and reside in the hair follicle bulge-subbulge area, the lower permanent portion of the hair follicle, to serve as a melanocyte reservoir for skin and hair pigmentation. MelSCs form a stem cell system within individual hair follicles and provide a 'hair pigmentary unit' for each cycle of hair pigmentation. This review focuses on the identification of MelSCs and their characteristics and explains the importance of the MelSC population in the mechanisms of hair pigmentation, hair greying, and skin repigmentation. SN - 1755-148X UR - https://www.unboundmedicine.com/medline/citation/21466661/Melanocyte_stem_cells:_a_melanocyte_reservoir_in_hair_follicles_for_hair_and_skin_pigmentation_ L2 - https://doi.org/10.1111/j.1755-148X.2011.00855.x DB - PRIME DP - Unbound Medicine ER -