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Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature.

Abstract

OBJECTIVES

The incidence of inflammatory bowel disease (IBD) is increasing. Dietary factors such as the spread of the "Western" diet, high in fat and protein but low in fruits and vegetables, may be associated with the increase. Although many studies have evaluated the association between diet and IBD risk, there has been no systematic review.

METHODS

We performed a systematic review using guideline-recommended methodology to evaluate the association between pre-illness intake of nutrients (fats, carbohydrates, protein) and food groups (fruits, vegetables, meats) and the risk of subsequent IBD diagnosis. Eligible studies were identified via structured keyword searches in PubMed and Google Scholar and manual searches.

RESULTS

Nineteen studies were included, encompassing 2,609 IBD patients (1,269 Crohn's disease (CD) and 1,340 ulcerative colitis (UC) patients) and over 4,000 controls. Studies reported a positive association between high intake of saturated fats, monounsaturated fatty acids, total polyunsaturated fatty acids (PUFAs), total omega-3 fatty acids, omega-6 fatty acids, mono- and disaccharides, and meat and increased subsequent CD risk. Studies reported a negative association between dietary fiber and fruits and subsequent CD risk. High intakes of total fats, total PUFAs, omega-6 fatty acids, and meat were associated with an increased risk of UC. High vegetable intake was associated with a decreased risk of UC.

CONCLUSIONS

High dietary intakes of total fats, PUFAs, omega-6 fatty acids, and meat were associated with an increased risk of CD and UC. High fiber and fruit intakes were associated with decreased CD risk, and high vegetable intake was associated with decreased UC risk.

Links

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  • Authors+Show Affiliations

    ,

    Section of Gastroenterology, Baylor College of Medicine, Houston, TX, USA. jkhou@bcm.tmc.edu

    ,

    Source

    MeSH

    Colitis, Ulcerative
    Crohn Disease
    Diet
    Dietary Carbohydrates
    Dietary Fats
    Dietary Fiber
    Dietary Proteins
    Fatty Acids, Omega-6
    Fatty Acids, Unsaturated
    Fruit
    Humans
    Inflammatory Bowel Diseases
    Meat
    Risk Assessment
    Vegetables

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural
    Research Support, Non-U.S. Gov't
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    21468064

    Citation

    Hou, Jason K., et al. "Dietary Intake and Risk of Developing Inflammatory Bowel Disease: a Systematic Review of the Literature." The American Journal of Gastroenterology, vol. 106, no. 4, 2011, pp. 563-73.
    Hou JK, Abraham B, El-Serag H. Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. Am J Gastroenterol. 2011;106(4):563-73.
    Hou, J. K., Abraham, B., & El-Serag, H. (2011). Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. The American Journal of Gastroenterology, 106(4), pp. 563-73. doi:10.1038/ajg.2011.44.
    Hou JK, Abraham B, El-Serag H. Dietary Intake and Risk of Developing Inflammatory Bowel Disease: a Systematic Review of the Literature. Am J Gastroenterol. 2011;106(4):563-73. PubMed PMID: 21468064.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Dietary intake and risk of developing inflammatory bowel disease: a systematic review of the literature. AU - Hou,Jason K, AU - Abraham,Bincy, AU - El-Serag,Hashem, PY - 2011/4/7/entrez PY - 2011/4/7/pubmed PY - 2011/6/7/medline SP - 563 EP - 73 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 106 IS - 4 N2 - OBJECTIVES: The incidence of inflammatory bowel disease (IBD) is increasing. Dietary factors such as the spread of the "Western" diet, high in fat and protein but low in fruits and vegetables, may be associated with the increase. Although many studies have evaluated the association between diet and IBD risk, there has been no systematic review. METHODS: We performed a systematic review using guideline-recommended methodology to evaluate the association between pre-illness intake of nutrients (fats, carbohydrates, protein) and food groups (fruits, vegetables, meats) and the risk of subsequent IBD diagnosis. Eligible studies were identified via structured keyword searches in PubMed and Google Scholar and manual searches. RESULTS: Nineteen studies were included, encompassing 2,609 IBD patients (1,269 Crohn's disease (CD) and 1,340 ulcerative colitis (UC) patients) and over 4,000 controls. Studies reported a positive association between high intake of saturated fats, monounsaturated fatty acids, total polyunsaturated fatty acids (PUFAs), total omega-3 fatty acids, omega-6 fatty acids, mono- and disaccharides, and meat and increased subsequent CD risk. Studies reported a negative association between dietary fiber and fruits and subsequent CD risk. High intakes of total fats, total PUFAs, omega-6 fatty acids, and meat were associated with an increased risk of UC. High vegetable intake was associated with a decreased risk of UC. CONCLUSIONS: High dietary intakes of total fats, PUFAs, omega-6 fatty acids, and meat were associated with an increased risk of CD and UC. High fiber and fruit intakes were associated with decreased CD risk, and high vegetable intake was associated with decreased UC risk. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/21468064/Dietary_intake_and_risk_of_developing_inflammatory_bowel_disease:_a_systematic_review_of_the_literature_ L2 - http://Insights.ovid.com/pubmed?pmid=21468064 DB - PRIME DP - Unbound Medicine ER -