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The relation of thyroid function to components of the metabolic syndrome in Korean men and women.
J Korean Med Sci. 2011 Apr; 26(4):540-5.JK

Abstract

This study was to assess the relation of thyroid dysfunction to metabolic syndrome (MetS) at an earlier stage in Korean population. Metabolic parameters such as body composition, blood pressure (BP), fasting glucose, total cholesterol, triglyceride (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), thyroid-stimulating hormone (TSH) and free thyroxine 4 (fT(4)) were measured. During a mean follow-up of 3 yr, 5,998 Koreans ages over 18 yr were assessed. There were 694 cases of MetS at follow-up. The mean age of the subjects was 45.6 ± 9.5 yr. Mean level of TSH was 2.02 ± 1.50 mIU/L, mean level of fT(4) was 1.23 ± 0.20 ρM/L. At baseline, TSH levels and fT(4) levels were associated to waist circumference, BP, glucose and lipids in the subjects. Increase in systolic blood pressure, diastolic blood pressure (DBP), total cholesterol and TG were significantly associated with changes in TSH levels after adjustment. Changes in DBP, TG, HDL-C and fasting glucose were significantly associated with changes in fT(4) levels after adjustment. Increase in TSH levels even after further controlling for baseline TSH level predicted the MetS over the study period. In conclusion, there is a relationship between thyroid function and cardiovascular risk factors, such as BP, total cholesterol, TG, HDL-C and fasting glucose. Also, higher levels of TSH may predict the MetS in Korean.

Authors+Show Affiliations

Department of Family Practice and Community Health, Ajou University School of Medicine, 164 Worldcup-ro, Yeongtong-gu, Suwon, Korea. sbpark@ajou.ac.krNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21468262

Citation

Park, Sat Byul, et al. "The Relation of Thyroid Function to Components of the Metabolic Syndrome in Korean Men and Women." Journal of Korean Medical Science, vol. 26, no. 4, 2011, pp. 540-5.
Park SB, Choi HC, Joo NS. The relation of thyroid function to components of the metabolic syndrome in Korean men and women. J Korean Med Sci. 2011;26(4):540-5.
Park, S. B., Choi, H. C., & Joo, N. S. (2011). The relation of thyroid function to components of the metabolic syndrome in Korean men and women. Journal of Korean Medical Science, 26(4), 540-5. https://doi.org/10.3346/jkms.2011.26.4.540
Park SB, Choi HC, Joo NS. The Relation of Thyroid Function to Components of the Metabolic Syndrome in Korean Men and Women. J Korean Med Sci. 2011;26(4):540-5. PubMed PMID: 21468262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The relation of thyroid function to components of the metabolic syndrome in Korean men and women. AU - Park,Sat Byul, AU - Choi,Ho Chun, AU - Joo,Nam Seok, Y1 - 2011/03/28/ PY - 2010/10/06/received PY - 2011/02/17/accepted PY - 2011/4/7/entrez PY - 2011/4/7/pubmed PY - 2011/11/10/medline KW - Cardiovascular Risk Factors KW - Insulin Resistance KW - Metabolic Syndrome KW - Thyroid Function SP - 540 EP - 5 JF - Journal of Korean medical science JO - J Korean Med Sci VL - 26 IS - 4 N2 - This study was to assess the relation of thyroid dysfunction to metabolic syndrome (MetS) at an earlier stage in Korean population. Metabolic parameters such as body composition, blood pressure (BP), fasting glucose, total cholesterol, triglyceride (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C), thyroid-stimulating hormone (TSH) and free thyroxine 4 (fT(4)) were measured. During a mean follow-up of 3 yr, 5,998 Koreans ages over 18 yr were assessed. There were 694 cases of MetS at follow-up. The mean age of the subjects was 45.6 ± 9.5 yr. Mean level of TSH was 2.02 ± 1.50 mIU/L, mean level of fT(4) was 1.23 ± 0.20 ρM/L. At baseline, TSH levels and fT(4) levels were associated to waist circumference, BP, glucose and lipids in the subjects. Increase in systolic blood pressure, diastolic blood pressure (DBP), total cholesterol and TG were significantly associated with changes in TSH levels after adjustment. Changes in DBP, TG, HDL-C and fasting glucose were significantly associated with changes in fT(4) levels after adjustment. Increase in TSH levels even after further controlling for baseline TSH level predicted the MetS over the study period. In conclusion, there is a relationship between thyroid function and cardiovascular risk factors, such as BP, total cholesterol, TG, HDL-C and fasting glucose. Also, higher levels of TSH may predict the MetS in Korean. SN - 1598-6357 UR - https://www.unboundmedicine.com/medline/citation/21468262/The_relation_of_thyroid_function_to_components_of_the_metabolic_syndrome_in_Korean_men_and_women_ L2 - https://jkms.org/DOIx.php?id=10.3346/jkms.2011.26.4.540 DB - PRIME DP - Unbound Medicine ER -