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The prevalence of celiac disease in patients with irritable bowel syndrome.
Mol Med Rep. 2011 May-Jun; 4(3):403-5.MM

Abstract

The diagnosis of irritable bowel syndrome (IBS) is based on symptom assessment such as the Rome III criteria. It is sometimes difficult to clinically distinguish IBS from adult-onset celiac disease (CD). Individuals with CD presenting with relatively vague abdominal symptoms are at risk of been dismissed as having IBS. This study aimed to investigate the prevalence of patients with CD among those that fulfill the Rome III criteria for IBS from among patients referred to the gastroenterology section of our hospital over the last 5 years. The study included a total of 968 patients with an average age of 32 years (range 18-59 years). Females constituted 95% of all patients. Duodenal biopsies were obtained during standard gastroscopy. Sections from these biopsies were stained with haematoxylin and eosin and immunostained for human leucocytes CD45 using the avidin-biotin complex (ABC) method. The sections were then histopathologically examined. Four patients had CD: one with Marsh type 3b, and 3 with Marsh type 1. All four of these patients were positive for tissue transglutminase antibodies (anti-t-TG) IgA and were females aged 24, 20, 36 and 38 years. These 4 patients fulfilled the Rome III criteria for the sub-type IBS-diarrhea. This amounts to a prevalence of 0.4% of CD in IBS patients. The present findings support the notion that IBS patients should be routinely examined for CD. This applies to all subtypes of IBS.

Authors+Show Affiliations

Section for Gastroenterology, Medicine Clinic, Stord Helse-Fonna Hospital, Stord, Norway. magdy.el-salhy@helse-fonna.noNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21468583

Citation

El-Salhy, M, et al. "The Prevalence of Celiac Disease in Patients With Irritable Bowel Syndrome." Molecular Medicine Reports, vol. 4, no. 3, 2011, pp. 403-5.
El-Salhy M, Lomholt-Beck B, Gundersen D. The prevalence of celiac disease in patients with irritable bowel syndrome. Mol Med Rep. 2011;4(3):403-5.
El-Salhy, M., Lomholt-Beck, B., & Gundersen, D. (2011). The prevalence of celiac disease in patients with irritable bowel syndrome. Molecular Medicine Reports, 4(3), 403-5. https://doi.org/10.3892/mmr.2011.466
El-Salhy M, Lomholt-Beck B, Gundersen D. The Prevalence of Celiac Disease in Patients With Irritable Bowel Syndrome. Mol Med Rep. 2011 May-Jun;4(3):403-5. PubMed PMID: 21468583.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The prevalence of celiac disease in patients with irritable bowel syndrome. AU - El-Salhy,M, AU - Lomholt-Beck,B, AU - Gundersen,D, Y1 - 2011/03/22/ PY - 2011/01/26/received PY - 2011/03/07/accepted PY - 2011/4/7/entrez PY - 2011/4/7/pubmed PY - 2011/7/14/medline SP - 403 EP - 5 JF - Molecular medicine reports JO - Mol Med Rep VL - 4 IS - 3 N2 - The diagnosis of irritable bowel syndrome (IBS) is based on symptom assessment such as the Rome III criteria. It is sometimes difficult to clinically distinguish IBS from adult-onset celiac disease (CD). Individuals with CD presenting with relatively vague abdominal symptoms are at risk of been dismissed as having IBS. This study aimed to investigate the prevalence of patients with CD among those that fulfill the Rome III criteria for IBS from among patients referred to the gastroenterology section of our hospital over the last 5 years. The study included a total of 968 patients with an average age of 32 years (range 18-59 years). Females constituted 95% of all patients. Duodenal biopsies were obtained during standard gastroscopy. Sections from these biopsies were stained with haematoxylin and eosin and immunostained for human leucocytes CD45 using the avidin-biotin complex (ABC) method. The sections were then histopathologically examined. Four patients had CD: one with Marsh type 3b, and 3 with Marsh type 1. All four of these patients were positive for tissue transglutminase antibodies (anti-t-TG) IgA and were females aged 24, 20, 36 and 38 years. These 4 patients fulfilled the Rome III criteria for the sub-type IBS-diarrhea. This amounts to a prevalence of 0.4% of CD in IBS patients. The present findings support the notion that IBS patients should be routinely examined for CD. This applies to all subtypes of IBS. SN - 1791-3004 UR - https://www.unboundmedicine.com/medline/citation/21468583/The_prevalence_of_celiac_disease_in_patients_with_irritable_bowel_syndrome_ L2 - http://www.spandidos-publications.com/mmr/4/3/403 DB - PRIME DP - Unbound Medicine ER -