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Elimination of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol when normalized to urinary creatinine.
Res Commun Mol Pathol Pharmacol. 2007-2008; 120-121(1-6):67-78.RC

Abstract

Gas chromatography mass/spectrometry quantitative analysis of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THCCOOH), the major metabolite of delta-9-tetrahydrocannabinol (THC) found in urine following marijuana use, was performed on serial urine specimens collected from an inpatient adolescent population of marijuana users. Creatinine normalization of THCCOOH was used to compensate for dilute or concentrated urine specimens. The urinary terminal elimination rate constant and terminal half-life was calculated for each subject. The mean urinary elimination rate constant for THCCOOH normalized to creatinine was 0.08433 days(-1) (range 0.05408-0.16544) reflecting a 8.22 day terminal half-life. A half-life of 1.15 days was observed for the initial decline phase of THCCOOH corrected by creatinine suggesting that reuse of marijuana can be detected after this phase ends. The creatinine normalized THCCOOH level was a better indicator for predicting reuse of marijuana than urinary concentrations of THCCOOH. The Mean Residence Time (MRT) of THCCOOH/Cr (5.7 days) correlated well with the length of time a subject will have detectable urinary THCCOOH concentrations (20.8 days).

Authors+Show Affiliations

College of Pharmacy, Oregon State University, 1601 SW Jefferson Ave, Corvallis OR, 97331-3507 Oregon, USA.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21469505

Citation

Beardsley, Grant D., and J Mark Christensen. "Elimination of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol when Normalized to Urinary Creatinine." Research Communications in Molecular Pathology and Pharmacology, vol. 120-121, no. 1-6, 2008, pp. 67-78.
Beardsley GD, Christensen JM. Elimination of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol when normalized to urinary creatinine. Res Commun Mol Pathol Pharmacol. 2008;120-121(1-6):67-78.
Beardsley, G. D., & Christensen, J. M. (2008). Elimination of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol when normalized to urinary creatinine. Research Communications in Molecular Pathology and Pharmacology, 120-121(1-6), 67-78.
Beardsley GD, Christensen JM. Elimination of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol when Normalized to Urinary Creatinine. Res Commun Mol Pathol Pharmacol. 2007-2008;120-121(1-6):67-78. PubMed PMID: 21469505.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elimination of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol when normalized to urinary creatinine. AU - Beardsley,Grant D, AU - Christensen,J Mark, PY - 2011/4/8/entrez PY - 2007/1/1/pubmed PY - 2011/6/1/medline SP - 67 EP - 78 JF - Research communications in molecular pathology and pharmacology JO - Res Commun Mol Pathol Pharmacol VL - 120-121 IS - 1-6 N2 - Gas chromatography mass/spectrometry quantitative analysis of 11-nor-9-carboxy-delta-9-tetrahydrocannabinol (THCCOOH), the major metabolite of delta-9-tetrahydrocannabinol (THC) found in urine following marijuana use, was performed on serial urine specimens collected from an inpatient adolescent population of marijuana users. Creatinine normalization of THCCOOH was used to compensate for dilute or concentrated urine specimens. The urinary terminal elimination rate constant and terminal half-life was calculated for each subject. The mean urinary elimination rate constant for THCCOOH normalized to creatinine was 0.08433 days(-1) (range 0.05408-0.16544) reflecting a 8.22 day terminal half-life. A half-life of 1.15 days was observed for the initial decline phase of THCCOOH corrected by creatinine suggesting that reuse of marijuana can be detected after this phase ends. The creatinine normalized THCCOOH level was a better indicator for predicting reuse of marijuana than urinary concentrations of THCCOOH. The Mean Residence Time (MRT) of THCCOOH/Cr (5.7 days) correlated well with the length of time a subject will have detectable urinary THCCOOH concentrations (20.8 days). SN - 1078-0297 UR - https://www.unboundmedicine.com/medline/citation/21469505/Elimination_of_11_nor_9_carboxy_delta_9_tetrahydrocannabinol_when_normalized_to_urinary_creatinine_ DB - PRIME DP - Unbound Medicine ER -