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A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids.
Atherosclerosis. 1990 Aug; 83(2-3):167-75.A

Abstract

Intraindividual comparisons of diets supplemented with sunflowerseed oil (rich in linoleic acid, LA, C18:2n-6), linseed oil (enriched with alpha-linolenic acid, LNA, C18:3n-3) and canned mackerel (rich in eicosapentaenoic acid, EPA, C20:5n-3 and docosahexaenoic acid, DHA, C22:6n-3) were made in 30 patients with primary hyperlipoproteinemia (HLP) of phenotypes IIa (n = 9), IIb (n = 7), IV (n = 7) and V (n = 7). The lipid- and blood pressure-lowering effects of polyunsaturated fatty acids (PUFA), particularly those of the EPA- and DHA-rich diet, were confirmed irrespective of the type of HLP. Apolipoproteins A-I and B remained unchanged. The most remarkable finding was a substantial depression of free fatty acids (FFA) within a standardized glucose tolerance test (GTT) associated with the fall of serum triglycerides after diets enriched with n-6 and especially after those supplemented with n-3 PUFA. It was suggested that the decrease of FFA indicates reduced peripheral lipolysis, which might be a hitherto ignored factor involved in the triglyceride-lowering action of n-6 and, more pronounced, of n-3 PUFA.

Authors+Show Affiliations

Central Institute for Cardiovascular Research, Academy of Sciences Berlin-Buch, G.D.R.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2146966

Citation

Singer, P, et al. "A Possible Contribution of Decrease in Free Fatty Acids to Low Serum Triglyceride Levels After Diets Supplemented With N-6 and N-3 Polyunsaturated Fatty Acids." Atherosclerosis, vol. 83, no. 2-3, 1990, pp. 167-75.
Singer P, Wirth M, Berger I. A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. Atherosclerosis. 1990;83(2-3):167-75.
Singer, P., Wirth, M., & Berger, I. (1990). A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. Atherosclerosis, 83(2-3), 167-75.
Singer P, Wirth M, Berger I. A Possible Contribution of Decrease in Free Fatty Acids to Low Serum Triglyceride Levels After Diets Supplemented With N-6 and N-3 Polyunsaturated Fatty Acids. Atherosclerosis. 1990;83(2-3):167-75. PubMed PMID: 2146966.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A possible contribution of decrease in free fatty acids to low serum triglyceride levels after diets supplemented with n-6 and n-3 polyunsaturated fatty acids. AU - Singer,P, AU - Wirth,M, AU - Berger,I, PY - 1990/8/1/pubmed PY - 1990/8/1/medline PY - 1990/8/1/entrez SP - 167 EP - 75 JF - Atherosclerosis JO - Atherosclerosis VL - 83 IS - 2-3 N2 - Intraindividual comparisons of diets supplemented with sunflowerseed oil (rich in linoleic acid, LA, C18:2n-6), linseed oil (enriched with alpha-linolenic acid, LNA, C18:3n-3) and canned mackerel (rich in eicosapentaenoic acid, EPA, C20:5n-3 and docosahexaenoic acid, DHA, C22:6n-3) were made in 30 patients with primary hyperlipoproteinemia (HLP) of phenotypes IIa (n = 9), IIb (n = 7), IV (n = 7) and V (n = 7). The lipid- and blood pressure-lowering effects of polyunsaturated fatty acids (PUFA), particularly those of the EPA- and DHA-rich diet, were confirmed irrespective of the type of HLP. Apolipoproteins A-I and B remained unchanged. The most remarkable finding was a substantial depression of free fatty acids (FFA) within a standardized glucose tolerance test (GTT) associated with the fall of serum triglycerides after diets enriched with n-6 and especially after those supplemented with n-3 PUFA. It was suggested that the decrease of FFA indicates reduced peripheral lipolysis, which might be a hitherto ignored factor involved in the triglyceride-lowering action of n-6 and, more pronounced, of n-3 PUFA. SN - 0021-9150 UR - https://www.unboundmedicine.com/medline/citation/2146966/A_possible_contribution_of_decrease_in_free_fatty_acids_to_low_serum_triglyceride_levels_after_diets_supplemented_with_n_6_and_n_3_polyunsaturated_fatty_acids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0021-9150(90)90162-C DB - PRIME DP - Unbound Medicine ER -