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A study of the compaction process and the properties of tablets made of a new co-processed starch excipient.
Drug Dev Ind Pharm. 2011 May; 37(5):576-82.DD

Abstract

This article deals with the study of the energetic relationships during compaction and the properties of tablets produced from a co-processed excipient based on starch and called StarCap 1500®. This article compares it with the substance Starch1500®. The study also includes the mixtures of StarCap 1500® and the granulated directly compressible lactose Pharmatose DCL®15. The tablet properties tested included tensile strength and disintegration time, examined in dependence on compression force, and also a 0.4% addition of magnesium stearate. The results show a better compressibility of StarCap 1500 in comparison with Starch 1500 and a lower elastic component of energy. The tablets were stronger and disintegrated more rapidly, but the substance possessed a higher sensitivity to an addition of a lubricant than Starch 1500. Increasing portions of StarCap 1500 in the mixtures with Pharmatose DCL 15 increased the tensile strength of tablets, disintegration period as well as the sensitivity to an addition of a lubricant. From the energetic viewpoint, energy for friction was decreasing, while the energy accumulated by the tablet during compaction and the elastic component of energy were increased.

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Authors+Show Affiliations

Mužíková J
Department of Pharmaceutical Technology, Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Czech Republic. muzikova@faf.cuni.cz
Eimerová I
No affiliation info available

MeSH

Compressive StrengthDrug CompoundingExcipientsLactoseLubricantsStarchTabletsTechnology, PharmaceuticalTensile Strength

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21469946

Citation

Mužíková, Jitka, and Irena Eimerová. "A Study of the Compaction Process and the Properties of Tablets Made of a New Co-processed Starch Excipient." Drug Development and Industrial Pharmacy, vol. 37, no. 5, 2011, pp. 576-82.
Mužíková J, Eimerová I. A study of the compaction process and the properties of tablets made of a new co-processed starch excipient. Drug Dev Ind Pharm. 2011;37(5):576-82.
Mužíková, J., & Eimerová, I. (2011). A study of the compaction process and the properties of tablets made of a new co-processed starch excipient. Drug Development and Industrial Pharmacy, 37(5), 576-82. https://doi.org/10.3109/03639045.2010.530270
Mužíková J, Eimerová I. A Study of the Compaction Process and the Properties of Tablets Made of a New Co-processed Starch Excipient. Drug Dev Ind Pharm. 2011;37(5):576-82. PubMed PMID: 21469946.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A study of the compaction process and the properties of tablets made of a new co-processed starch excipient. AU - Mužíková,Jitka, AU - Eimerová,Irena, PY - 2011/4/8/entrez PY - 2011/4/8/pubmed PY - 2011/8/9/medline SP - 576 EP - 82 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 37 IS - 5 N2 - This article deals with the study of the energetic relationships during compaction and the properties of tablets produced from a co-processed excipient based on starch and called StarCap 1500®. This article compares it with the substance Starch1500®. The study also includes the mixtures of StarCap 1500® and the granulated directly compressible lactose Pharmatose DCL®15. The tablet properties tested included tensile strength and disintegration time, examined in dependence on compression force, and also a 0.4% addition of magnesium stearate. The results show a better compressibility of StarCap 1500 in comparison with Starch 1500 and a lower elastic component of energy. The tablets were stronger and disintegrated more rapidly, but the substance possessed a higher sensitivity to an addition of a lubricant than Starch 1500. Increasing portions of StarCap 1500 in the mixtures with Pharmatose DCL 15 increased the tensile strength of tablets, disintegration period as well as the sensitivity to an addition of a lubricant. From the energetic viewpoint, energy for friction was decreasing, while the energy accumulated by the tablet during compaction and the elastic component of energy were increased. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/21469946/A_study_of_the_compaction_process_and_the_properties_of_tablets_made_of_a_new_co_processed_starch_excipient_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639045.2010.530270 DB - PRIME DP - Unbound Medicine ER -