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In vitro and in vivo studies on the complexes of glipizide with water-soluble β-cyclodextrin-epichlorohydrin polymers.
Drug Dev Ind Pharm. 2011 May; 37(5):606-12.DD

Abstract

The purpose of this study was to evaluate the potential of a newly modified cyclodextrin derivative, water-soluble β-cyclodextrin-epichlorohydrin polymer (β-CDP), as an effective drug carrier to enhance the dissolution rate and oral bioavailability of glipizide as a poorly water-soluble model drug. Inclusion complexes of glipizide with β-CDP were prepared by the co-evaporation method and characterized by phase solubility, dissolution, and differential scanning calorimetry. The solubility curve was classified as type A(L), which indicated the formation of 1:1 complex between glipizide and β-CDP. β-CDP had better properties of increasing the aqueous solubility of glipizide compared with HP-β-CD. The dissolution rate of drug from the β-CDP complexes was significantly greater than that of the corresponding physical mixtures indicating that the formation of amorphous complex increased the solubility of glipizide. Moreover, the increment in drug dissolution rate from the glipizide/β-CDP systems was higher than that from the corresponding ones with HP-β-CD, which indicated that β-CDP could provide greater capability of solubilization for poorly soluble drugs. Furthermore, in vivo study revealed that the bioavailability of glipizide was significantly improved by glipizide /β-CDP inclusion complex after oral administration to beagle dogs.

Authors+Show Affiliations

Department of Pharmaceutical Engineering, Wuhan Bioengineering Institute, Yangluo Economic Development Zone, Han-Shi Road 1, Wuhan, China. niesf77@163.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21469949

Citation

Nie, Shufang, et al. "In Vitro and in Vivo Studies On the Complexes of Glipizide With Water-soluble Β-cyclodextrin-epichlorohydrin Polymers." Drug Development and Industrial Pharmacy, vol. 37, no. 5, 2011, pp. 606-12.
Nie S, Zhang S, Pan W, et al. In vitro and in vivo studies on the complexes of glipizide with water-soluble β-cyclodextrin-epichlorohydrin polymers. Drug Dev Ind Pharm. 2011;37(5):606-12.
Nie, S., Zhang, S., Pan, W., & Liu, Y. (2011). In vitro and in vivo studies on the complexes of glipizide with water-soluble β-cyclodextrin-epichlorohydrin polymers. Drug Development and Industrial Pharmacy, 37(5), 606-12. https://doi.org/10.3109/03639045.2010.533277
Nie S, et al. In Vitro and in Vivo Studies On the Complexes of Glipizide With Water-soluble Β-cyclodextrin-epichlorohydrin Polymers. Drug Dev Ind Pharm. 2011;37(5):606-12. PubMed PMID: 21469949.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - In vitro and in vivo studies on the complexes of glipizide with water-soluble β-cyclodextrin-epichlorohydrin polymers. AU - Nie,Shufang, AU - Zhang,Shu, AU - Pan,Weisan, AU - Liu,Yanli, PY - 2011/4/8/entrez PY - 2011/4/8/pubmed PY - 2011/8/9/medline SP - 606 EP - 12 JF - Drug development and industrial pharmacy JO - Drug Dev Ind Pharm VL - 37 IS - 5 N2 - The purpose of this study was to evaluate the potential of a newly modified cyclodextrin derivative, water-soluble β-cyclodextrin-epichlorohydrin polymer (β-CDP), as an effective drug carrier to enhance the dissolution rate and oral bioavailability of glipizide as a poorly water-soluble model drug. Inclusion complexes of glipizide with β-CDP were prepared by the co-evaporation method and characterized by phase solubility, dissolution, and differential scanning calorimetry. The solubility curve was classified as type A(L), which indicated the formation of 1:1 complex between glipizide and β-CDP. β-CDP had better properties of increasing the aqueous solubility of glipizide compared with HP-β-CD. The dissolution rate of drug from the β-CDP complexes was significantly greater than that of the corresponding physical mixtures indicating that the formation of amorphous complex increased the solubility of glipizide. Moreover, the increment in drug dissolution rate from the glipizide/β-CDP systems was higher than that from the corresponding ones with HP-β-CD, which indicated that β-CDP could provide greater capability of solubilization for poorly soluble drugs. Furthermore, in vivo study revealed that the bioavailability of glipizide was significantly improved by glipizide /β-CDP inclusion complex after oral administration to beagle dogs. SN - 1520-5762 UR - https://www.unboundmedicine.com/medline/citation/21469949/In_vitro_and_in_vivo_studies_on_the_complexes_of_glipizide_with_water_soluble_β_cyclodextrin_epichlorohydrin_polymers_ L2 - https://www.tandfonline.com/doi/full/10.3109/03639045.2010.533277 DB - PRIME DP - Unbound Medicine ER -