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Comparative phototoxicity of nanoparticulate and bulk ZnO to a free-living nematode Caenorhabditis elegans: the importance of illumination mode and primary particle size.
Environ Pollut. 2011 Jun; 159(6):1473-80.EP

Abstract

The present study evaluated phototoxicity of nanoparticulate ZnO and bulk-ZnO under natural sunlight (NSL) versus ambient artificial laboratory light (AALL) illumination to a free-living nematode Caenorhabditis elegans. Phototoxicity of nano-ZnO and bulk-ZnO was largely dependent on illumination method as 2-h exposure under NSL caused significantly greater mortality in C. elegans than under AALL. This phototoxicity was closely related to photocatalytic reactive oxygen species (ROS) generation by the ZnO particles as indicated by concomitant methylene blue photodegradation. Both materials caused mortality in C. elegans under AALL during 24-h exposure although neither degraded methylene blue, suggesting mechanisms of toxicity other than photocatalytic ROS generation were involved. Particle dissolution of ZnO did not appear to play an important role in the toxicity observed in this study. Nano-ZnO showed greater phototoxicity than bulk-ZnO despite their similar size of aggregates, suggesting primary particle size is more important than aggregate size in determining phototoxicity.

Authors+Show Affiliations

Department of Environmental Health Science, College of Public Health, The University of Georgia, Athens, GA 30602, USA. mah77@uga.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

21470728

Citation

Ma, H, et al. "Comparative Phototoxicity of Nanoparticulate and Bulk ZnO to a Free-living Nematode Caenorhabditis Elegans: the Importance of Illumination Mode and Primary Particle Size." Environmental Pollution (Barking, Essex : 1987), vol. 159, no. 6, 2011, pp. 1473-80.
Ma H, Kabengi NJ, Bertsch PM, et al. Comparative phototoxicity of nanoparticulate and bulk ZnO to a free-living nematode Caenorhabditis elegans: the importance of illumination mode and primary particle size. Environ Pollut. 2011;159(6):1473-80.
Ma, H., Kabengi, N. J., Bertsch, P. M., Unrine, J. M., Glenn, T. C., & Williams, P. L. (2011). Comparative phototoxicity of nanoparticulate and bulk ZnO to a free-living nematode Caenorhabditis elegans: the importance of illumination mode and primary particle size. Environmental Pollution (Barking, Essex : 1987), 159(6), 1473-80. https://doi.org/10.1016/j.envpol.2011.03.013
Ma H, et al. Comparative Phototoxicity of Nanoparticulate and Bulk ZnO to a Free-living Nematode Caenorhabditis Elegans: the Importance of Illumination Mode and Primary Particle Size. Environ Pollut. 2011;159(6):1473-80. PubMed PMID: 21470728.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative phototoxicity of nanoparticulate and bulk ZnO to a free-living nematode Caenorhabditis elegans: the importance of illumination mode and primary particle size. AU - Ma,H, AU - Kabengi,N J, AU - Bertsch,P M, AU - Unrine,J M, AU - Glenn,T C, AU - Williams,P L, Y1 - 2011/04/05/ PY - 2010/11/17/received PY - 2011/03/14/revised PY - 2011/03/16/accepted PY - 2011/4/8/entrez PY - 2011/4/8/pubmed PY - 2011/8/9/medline SP - 1473 EP - 80 JF - Environmental pollution (Barking, Essex : 1987) JO - Environ Pollut VL - 159 IS - 6 N2 - The present study evaluated phototoxicity of nanoparticulate ZnO and bulk-ZnO under natural sunlight (NSL) versus ambient artificial laboratory light (AALL) illumination to a free-living nematode Caenorhabditis elegans. Phototoxicity of nano-ZnO and bulk-ZnO was largely dependent on illumination method as 2-h exposure under NSL caused significantly greater mortality in C. elegans than under AALL. This phototoxicity was closely related to photocatalytic reactive oxygen species (ROS) generation by the ZnO particles as indicated by concomitant methylene blue photodegradation. Both materials caused mortality in C. elegans under AALL during 24-h exposure although neither degraded methylene blue, suggesting mechanisms of toxicity other than photocatalytic ROS generation were involved. Particle dissolution of ZnO did not appear to play an important role in the toxicity observed in this study. Nano-ZnO showed greater phototoxicity than bulk-ZnO despite their similar size of aggregates, suggesting primary particle size is more important than aggregate size in determining phototoxicity. SN - 1873-6424 UR - https://www.unboundmedicine.com/medline/citation/21470728/Comparative_phototoxicity_of_nanoparticulate_and_bulk_ZnO_to_a_free_living_nematode_Caenorhabditis_elegans:_the_importance_of_illumination_mode_and_primary_particle_size_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0269-7491(11)00165-5 DB - PRIME DP - Unbound Medicine ER -