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Physical activity reduces breast cancer risk: a case-control study in Tunisia.
Cancer Epidemiol 2011; 35(6):540-4CE

Abstract

PURPOSE

This study examined the relationship between lifetime history of physical activity and breast cancer risk.

METHODS

The case-control study was conducted on 400 women with histological confirmed breast cancer operated during the 2006-2009 period at Farhat Hached University Hospital, Sousse, Tunisia, and 400 cancer-free controls, aged 25-75 years. The physical activity was assessed using a structured questionnaire on each activity: type, duration, frequency, and intensity. Odds ratios (ORs), 95% confidence intervals (CI) and a full confounding assessment, included in this analysis, were derived using logistic regression.

RESULTS

These cases had lower lifetime averages for total physical activity for both forms of activity measurements (hours/week/year and MET-hours/week/year) and (P(trend)<0.001 and P(trend)=0.002, respectively). Significant risk reductions were found in total physical activity for both forms of activity measurements (OR=0.27, 95% CI: 0.18-0.52, OR=0.42, 95% CI: 0.26-0.73, respectively) for the highest versus the lowest level of activity (P(trend)=0.001 and 0.004, respectively). The stratification by menopausal status showed a significant 56% reduction in breast cancer risk for post-menopausal women (P(trend)=0.001, adjusted for age). The risk was further reduced to 68% (P(trend)=0.002, multivariate adjusted). Among pre-menopausal women, the total physical activity was not significantly associated with reduced risk, ORs were 0.88 (95% CI: 0.40-1.99, age adjusted) and 0.43 (95% CI: 0.12-1.38, multivariate adjusted).

CONCLUSION

These data are in concordance with the majority of previous reports which involved physical inactivity as an important risk factor for breast cancer.

Authors+Show Affiliations

Department of Medical Oncology, CHU Farhat Hached, Sousse 4000, Tunisia. awatefmsolly@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21470932

Citation

Awatef, Msolly, et al. "Physical Activity Reduces Breast Cancer Risk: a Case-control Study in Tunisia." Cancer Epidemiology, vol. 35, no. 6, 2011, pp. 540-4.
Awatef M, Olfa G, Rim C, et al. Physical activity reduces breast cancer risk: a case-control study in Tunisia. Cancer Epidemiol. 2011;35(6):540-4.
Awatef, M., Olfa, G., Rim, C., Asma, K., Kacem, M., Makram, H., ... Slim, B. A. (2011). Physical activity reduces breast cancer risk: a case-control study in Tunisia. Cancer Epidemiology, 35(6), pp. 540-4. doi:10.1016/j.canep.2011.02.011.
Awatef M, et al. Physical Activity Reduces Breast Cancer Risk: a Case-control Study in Tunisia. Cancer Epidemiol. 2011;35(6):540-4. PubMed PMID: 21470932.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Physical activity reduces breast cancer risk: a case-control study in Tunisia. AU - Awatef,Msolly, AU - Olfa,Gharbi, AU - Rim,Chafai, AU - Asma,Kassab, AU - Kacem,Mahmoudi, AU - Makram,Hochlef, AU - Leila,Ben Fatma, AU - Amel,Landolsi, AU - Slim,Ben Ahmed, Y1 - 2011/04/05/ PY - 2010/11/12/received PY - 2011/02/13/revised PY - 2011/02/16/accepted PY - 2011/4/8/entrez PY - 2011/4/8/pubmed PY - 2012/3/7/medline SP - 540 EP - 4 JF - Cancer epidemiology JO - Cancer Epidemiol VL - 35 IS - 6 N2 - PURPOSE: This study examined the relationship between lifetime history of physical activity and breast cancer risk. METHODS: The case-control study was conducted on 400 women with histological confirmed breast cancer operated during the 2006-2009 period at Farhat Hached University Hospital, Sousse, Tunisia, and 400 cancer-free controls, aged 25-75 years. The physical activity was assessed using a structured questionnaire on each activity: type, duration, frequency, and intensity. Odds ratios (ORs), 95% confidence intervals (CI) and a full confounding assessment, included in this analysis, were derived using logistic regression. RESULTS: These cases had lower lifetime averages for total physical activity for both forms of activity measurements (hours/week/year and MET-hours/week/year) and (P(trend)<0.001 and P(trend)=0.002, respectively). Significant risk reductions were found in total physical activity for both forms of activity measurements (OR=0.27, 95% CI: 0.18-0.52, OR=0.42, 95% CI: 0.26-0.73, respectively) for the highest versus the lowest level of activity (P(trend)=0.001 and 0.004, respectively). The stratification by menopausal status showed a significant 56% reduction in breast cancer risk for post-menopausal women (P(trend)=0.001, adjusted for age). The risk was further reduced to 68% (P(trend)=0.002, multivariate adjusted). Among pre-menopausal women, the total physical activity was not significantly associated with reduced risk, ORs were 0.88 (95% CI: 0.40-1.99, age adjusted) and 0.43 (95% CI: 0.12-1.38, multivariate adjusted). CONCLUSION: These data are in concordance with the majority of previous reports which involved physical inactivity as an important risk factor for breast cancer. SN - 1877-783X UR - https://www.unboundmedicine.com/medline/citation/21470932/Physical_activity_reduces_breast_cancer_risk:_a_case_control_study_in_Tunisia_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1877-7821(11)00036-1 DB - PRIME DP - Unbound Medicine ER -