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How we can improve patients' comfort after Milligan-Morgan open haemorrhoidectomy.
World J Gastroenterol. 2011 Mar 21; 17(11):1448-56.WJ

Abstract

AIM

To demonstrate the value of Diosmin (flavonidic fraction) in the management of post-haemorhoidectomic symptoms.

METHODS

Eighty-six consecutive patients with grades III and IV acute mixed hemorrhoids admitted to the Anorectal Surgical Department of First Affiliated Hospital, Xinjiang Medical University from April 2009 to April 2010, were enrolled in this study. An observer-blinded, randomized trial was conducted to compare post-haemorhoidectomic symptoms with use of Diosmin flavonidic fraction vs placebo. Eighty-six patients were randomly allocated to receive Diosmin flavonidic fraction 500 mg for 1 wk (n = 43) or placebo (n = 43). The Milligan-Morgan open haemorrhoidectomy was performed by a standardized diathermy excision method. Pain, bleeding, heaviness, pruritus, wound edema and mucosal discharge were observed after surgery. The postoperative symptoms and hospitalization time were recorded.

RESULTS

The mean age of the Diosmin group and controls was 53.2 and 51.3 years, respectively. In Diosmin group, haemorrhoid piles were of the third degree in 33 patients and the fourth degree in 10; and in the control group, 29 were of the third degree and 14 were of the fourth degree. There was no statistically significance in age, gender distribution, degree and number of excised haemorrhoid piles, and the mean duration of haemorrhoidal disease between the two groups. There was a statistically significant improvement in pain, heaviness, bleeding, pruritus from baseline to the 8th week after operation (P < 0.05). Patients taking Diosmin had a shorter hospitalization stay after surgery (P < 0.05). There was also a significant improvement on the proctoscopic appearance (P < 0.001). However, there was no statistical difference between the two groups in terms of wound mucosal discharge. Two patients experienced minor bleeding at the 8th week in Diosmin group, and underwent surgery.

CONCLUSION

Diosmin is effective in alleviating postoperational symptoms of haemorrhoids. Therefore, it should be considered for the initial treatment after haemorrhoid surgery. However, further prospective randomized trials are needed to confirm the findings of this study.

Authors+Show Affiliations

Department of Anorectal Surgical, First Affiliated Hospital of Xinjiang Medical University, Urumqi 830011, Xinjiang Uygur Autonomous Region, China. mamutjan206@sina.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21472103

Citation

Ba-bai-ke-re, Ma-Mu-Ti-Jiang A., et al. "How We Can Improve Patients' Comfort After Milligan-Morgan Open Haemorrhoidectomy." World Journal of Gastroenterology, vol. 17, no. 11, 2011, pp. 1448-56.
Ba-bai-ke-re MM, Huang HG, Re WN, et al. How we can improve patients' comfort after Milligan-Morgan open haemorrhoidectomy. World J Gastroenterol. 2011;17(11):1448-56.
Ba-bai-ke-re, M. M., Huang, H. G., Re, W. N., Fan, K., Chu, H., Ai, E. H., Li-Mu, M. M., Wang, Y. R., & Wen, H. (2011). How we can improve patients' comfort after Milligan-Morgan open haemorrhoidectomy. World Journal of Gastroenterology, 17(11), 1448-56. https://doi.org/10.3748/wjg.v17.i11.1448
Ba-bai-ke-re MM, et al. How We Can Improve Patients' Comfort After Milligan-Morgan Open Haemorrhoidectomy. World J Gastroenterol. 2011 Mar 21;17(11):1448-56. PubMed PMID: 21472103.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - How we can improve patients' comfort after Milligan-Morgan open haemorrhoidectomy. AU - Ba-bai-ke-re,Ma-Mu-Ti-Jiang A, AU - Huang,Hong-Guo, AU - Re,Wen-Ni, AU - Fan,Kai, AU - Chu,Hui, AU - Ai,Er-Ha-Ti, AU - Li-Mu,Mai-Mai-Ti-Tu-Er-Xun Ke, AU - Wang,Yi-Rui, AU - Wen,Hao, PY - 2010/09/14/received PY - 2010/12/09/revised PY - 2010/12/16/accepted PY - 2011/4/8/entrez PY - 2011/4/8/pubmed PY - 2011/7/26/medline KW - Flavonidic fraction KW - Haemorrhoids KW - Postoperative complication SP - 1448 EP - 56 JF - World journal of gastroenterology JO - World J Gastroenterol VL - 17 IS - 11 N2 - AIM: To demonstrate the value of Diosmin (flavonidic fraction) in the management of post-haemorhoidectomic symptoms. METHODS: Eighty-six consecutive patients with grades III and IV acute mixed hemorrhoids admitted to the Anorectal Surgical Department of First Affiliated Hospital, Xinjiang Medical University from April 2009 to April 2010, were enrolled in this study. An observer-blinded, randomized trial was conducted to compare post-haemorhoidectomic symptoms with use of Diosmin flavonidic fraction vs placebo. Eighty-six patients were randomly allocated to receive Diosmin flavonidic fraction 500 mg for 1 wk (n = 43) or placebo (n = 43). The Milligan-Morgan open haemorrhoidectomy was performed by a standardized diathermy excision method. Pain, bleeding, heaviness, pruritus, wound edema and mucosal discharge were observed after surgery. The postoperative symptoms and hospitalization time were recorded. RESULTS: The mean age of the Diosmin group and controls was 53.2 and 51.3 years, respectively. In Diosmin group, haemorrhoid piles were of the third degree in 33 patients and the fourth degree in 10; and in the control group, 29 were of the third degree and 14 were of the fourth degree. There was no statistically significance in age, gender distribution, degree and number of excised haemorrhoid piles, and the mean duration of haemorrhoidal disease between the two groups. There was a statistically significant improvement in pain, heaviness, bleeding, pruritus from baseline to the 8th week after operation (P < 0.05). Patients taking Diosmin had a shorter hospitalization stay after surgery (P < 0.05). There was also a significant improvement on the proctoscopic appearance (P < 0.001). However, there was no statistical difference between the two groups in terms of wound mucosal discharge. Two patients experienced minor bleeding at the 8th week in Diosmin group, and underwent surgery. CONCLUSION: Diosmin is effective in alleviating postoperational symptoms of haemorrhoids. Therefore, it should be considered for the initial treatment after haemorrhoid surgery. However, further prospective randomized trials are needed to confirm the findings of this study. SN - 2219-2840 UR - https://www.unboundmedicine.com/medline/citation/21472103/How_we_can_improve_patients'_comfort_after_Milligan_Morgan_open_haemorrhoidectomy_ L2 - https://www.wjgnet.com/1007-9327/full/v17/i11/1448.htm DB - PRIME DP - Unbound Medicine ER -