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Pandemic influenza H1N1 2009 infection in Victoria, Australia: no evidence for harm or benefit following receipt of seasonal influenza vaccine in 2009.
Vaccine 2011; 29(37):6419-26V

Abstract

Conflicting findings regarding the level of protection offered by seasonal influenza vaccination against pandemic influenza H1N1 have been reported. We performed a test-negative case control study using sentinel patients from general practices in Victoria to estimate seasonal influenza vaccine effectiveness against laboratory proven infection with pandemic influenza. Cases were defined as patients with an influenza-like illness who tested positive for influenza while controls had an influenza-like illness but tested negative. We found no evidence of significant protection from seasonal vaccine against pandemic influenza virus infection in any age group. Age-stratified point estimates, adjusted for pandemic phase, ranged from 44% in persons aged less than 5 years to -103% (odds ratio=2.03) in persons aged 50-64 years. Vaccine effectiveness, adjusted for age group and pandemic phase, was 3% (95% CI -48 to 37) for all patients. Our study confirms the results from our previous interim report, and other studies, that failed to demonstrate benefit or harm from receipt of seasonal influenza vaccine in patients with confirmed infection with pandemic influenza H1N1 2009.

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    Authors+Show Affiliations

    Kelly HA
    Victorian Infectious Diseases Reference Laboratory, Melbourne, Victoria, Australia. heath.kelly@mh.org.au
    Grant KA
    No affiliation info available
    Fielding JE
    No affiliation info available
    Carville KS
    No affiliation info available
    Looker CO
    No affiliation info available
    Tran T
    No affiliation info available
    Jacoby P
    No affiliation info available

    MeSH

    AdolescentAdultAgedAustraliaCase-Control StudiesChildChild, PreschoolDisease OutbreaksFemaleHumansInfantInfluenza A Virus, H1N1 SubtypeInfluenza VaccinesInfluenza, HumanMaleMiddle AgedVaccination

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21473950

    Citation

    Kelly, Heath A., et al. "Pandemic Influenza H1N1 2009 Infection in Victoria, Australia: No Evidence for Harm or Benefit Following Receipt of Seasonal Influenza Vaccine in 2009." Vaccine, vol. 29, no. 37, 2011, pp. 6419-26.
    Kelly HA, Grant KA, Fielding JE, et al. Pandemic influenza H1N1 2009 infection in Victoria, Australia: no evidence for harm or benefit following receipt of seasonal influenza vaccine in 2009. Vaccine. 2011;29(37):6419-26.
    Kelly, H. A., Grant, K. A., Fielding, J. E., Carville, K. S., Looker, C. O., Tran, T., & Jacoby, P. (2011). Pandemic influenza H1N1 2009 infection in Victoria, Australia: no evidence for harm or benefit following receipt of seasonal influenza vaccine in 2009. Vaccine, 29(37), pp. 6419-26. doi:10.1016/j.vaccine.2011.03.055.
    Kelly HA, et al. Pandemic Influenza H1N1 2009 Infection in Victoria, Australia: No Evidence for Harm or Benefit Following Receipt of Seasonal Influenza Vaccine in 2009. Vaccine. 2011 Aug 26;29(37):6419-26. PubMed PMID: 21473950.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Pandemic influenza H1N1 2009 infection in Victoria, Australia: no evidence for harm or benefit following receipt of seasonal influenza vaccine in 2009. AU - Kelly,Heath A, AU - Grant,Kristina A, AU - Fielding,James E, AU - Carville,Kylie S, AU - Looker,Clare O, AU - Tran,Thomas, AU - Jacoby,Peter, Y1 - 2011/04/05/ PY - 2010/08/04/received PY - 2011/03/07/revised PY - 2011/03/17/accepted PY - 2011/4/9/entrez PY - 2011/4/9/pubmed PY - 2012/2/9/medline SP - 6419 EP - 26 JF - Vaccine JO - Vaccine VL - 29 IS - 37 N2 - Conflicting findings regarding the level of protection offered by seasonal influenza vaccination against pandemic influenza H1N1 have been reported. We performed a test-negative case control study using sentinel patients from general practices in Victoria to estimate seasonal influenza vaccine effectiveness against laboratory proven infection with pandemic influenza. Cases were defined as patients with an influenza-like illness who tested positive for influenza while controls had an influenza-like illness but tested negative. We found no evidence of significant protection from seasonal vaccine against pandemic influenza virus infection in any age group. Age-stratified point estimates, adjusted for pandemic phase, ranged from 44% in persons aged less than 5 years to -103% (odds ratio=2.03) in persons aged 50-64 years. Vaccine effectiveness, adjusted for age group and pandemic phase, was 3% (95% CI -48 to 37) for all patients. Our study confirms the results from our previous interim report, and other studies, that failed to demonstrate benefit or harm from receipt of seasonal influenza vaccine in patients with confirmed infection with pandemic influenza H1N1 2009. SN - 1873-2518 UR - https://www.unboundmedicine.com/medline/citation/21473950/Pandemic_influenza_H1N1_2009_infection_in_Victoria_Australia:_no_evidence_for_harm_or_benefit_following_receipt_of_seasonal_influenza_vaccine_in_2009_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0264-410X(11)00437-3 DB - PRIME DP - Unbound Medicine ER -