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Elevation of serum thyroxine-binding globulin (but not of cortisol-binding globulin and sex hormone-binding globulin) associated with the progression of human immunodeficiency virus infection.
Am J Med. 1990 Dec; 89(6):748-51.AJ

Abstract

PURPOSE

In order to assess the relation of thyroid function tests to human immunodeficiency virus (HIV) infection, we determined the levels of serum thyroid hormones, serum binding proteins [thyroxine-binding globulin (TBG), cortisol-binding globulin (CBG), and sex hormone-binding globulin (SHBG)], and serum tumor necrosis factor (TNF) in HIV-seropositive subjects at different clinical stages.

PATIENTS AND METHODS

Thirty-seven HIV-seropositive patients were studied: 7 at stage II, 13 at stage III, and 17 at stage IV (eight ambulatory and nine hospitalized) according to the Centers for Disease Control's criteria.

RESULTS

As compared with stage II and stage III patients, stage IV patients had significantly higher mean TBG and total thyroxine (TT4) values, similar and normal total triiodothyronine (TT3) levels, and similar and abnormally low reverse triiodothyronine (rT3) concentrations. However, stage IV hospitalized patients had significantly lower TT3 values than stage IV ambulatory patients. In contrast to TBG, mean levels of CBG and SHBG were comparable in the three groups and within normal limits. For the whole population of HIV patients, there was a highly significant correlation between the CD4 lymphocyte count and TBG (r = -0.529, p less than 0.001) but not with CBG and SHBG levels. Finally, TNF values higher than 10 pg/mL were detected in six of the 17 stage IV patients and in only one of the 13 stage III patients (p = 0.059); elevated TNF levels correlated with a lower CD4 count (p less than 0.01) but not with serum TBG levels.

CONCLUSION

The progression of HIV infection is associated with an elevation of serum TNF and TBG, but not of CBG or SHBG. HIV-infected patients have an unexpectedly normal TT3-low rT3 state.

Authors+Show Affiliations

Division of General Internal Medicine and Nuclear Medicine, Saint-Luc University Hospital, Louvain Medical School, Brussels, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

2147539

Citation

Lambert, M, et al. "Elevation of Serum Thyroxine-binding Globulin (but Not of Cortisol-binding Globulin and Sex Hormone-binding Globulin) Associated With the Progression of Human Immunodeficiency Virus Infection." The American Journal of Medicine, vol. 89, no. 6, 1990, pp. 748-51.
Lambert M, Zech F, De Nayer P, et al. Elevation of serum thyroxine-binding globulin (but not of cortisol-binding globulin and sex hormone-binding globulin) associated with the progression of human immunodeficiency virus infection. Am J Med. 1990;89(6):748-51.
Lambert, M., Zech, F., De Nayer, P., Jamez, J., & Vandercam, B. (1990). Elevation of serum thyroxine-binding globulin (but not of cortisol-binding globulin and sex hormone-binding globulin) associated with the progression of human immunodeficiency virus infection. The American Journal of Medicine, 89(6), 748-51.
Lambert M, et al. Elevation of Serum Thyroxine-binding Globulin (but Not of Cortisol-binding Globulin and Sex Hormone-binding Globulin) Associated With the Progression of Human Immunodeficiency Virus Infection. Am J Med. 1990;89(6):748-51. PubMed PMID: 2147539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Elevation of serum thyroxine-binding globulin (but not of cortisol-binding globulin and sex hormone-binding globulin) associated with the progression of human immunodeficiency virus infection. AU - Lambert,M, AU - Zech,F, AU - De Nayer,P, AU - Jamez,J, AU - Vandercam,B, PY - 1990/12/1/pubmed PY - 1990/12/1/medline PY - 1990/12/1/entrez SP - 748 EP - 51 JF - The American journal of medicine JO - Am. J. Med. VL - 89 IS - 6 N2 - PURPOSE: In order to assess the relation of thyroid function tests to human immunodeficiency virus (HIV) infection, we determined the levels of serum thyroid hormones, serum binding proteins [thyroxine-binding globulin (TBG), cortisol-binding globulin (CBG), and sex hormone-binding globulin (SHBG)], and serum tumor necrosis factor (TNF) in HIV-seropositive subjects at different clinical stages. PATIENTS AND METHODS: Thirty-seven HIV-seropositive patients were studied: 7 at stage II, 13 at stage III, and 17 at stage IV (eight ambulatory and nine hospitalized) according to the Centers for Disease Control's criteria. RESULTS: As compared with stage II and stage III patients, stage IV patients had significantly higher mean TBG and total thyroxine (TT4) values, similar and normal total triiodothyronine (TT3) levels, and similar and abnormally low reverse triiodothyronine (rT3) concentrations. However, stage IV hospitalized patients had significantly lower TT3 values than stage IV ambulatory patients. In contrast to TBG, mean levels of CBG and SHBG were comparable in the three groups and within normal limits. For the whole population of HIV patients, there was a highly significant correlation between the CD4 lymphocyte count and TBG (r = -0.529, p less than 0.001) but not with CBG and SHBG levels. Finally, TNF values higher than 10 pg/mL were detected in six of the 17 stage IV patients and in only one of the 13 stage III patients (p = 0.059); elevated TNF levels correlated with a lower CD4 count (p less than 0.01) but not with serum TBG levels. CONCLUSION: The progression of HIV infection is associated with an elevation of serum TNF and TBG, but not of CBG or SHBG. HIV-infected patients have an unexpectedly normal TT3-low rT3 state. SN - 0002-9343 UR - https://www.unboundmedicine.com/medline/citation/2147539/Elevation_of_serum_thyroxine_binding_globulin__but_not_of_cortisol_binding_globulin_and_sex_hormone_binding_globulin__associated_with_the_progression_of_human_immunodeficiency_virus_infection_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0002-9343(90)90216-Z DB - PRIME DP - Unbound Medicine ER -