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A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes.
Arch Virol. 2011 Aug; 156(8):1345-58.AV

Abstract

To investigate the nationwide prevalence of hepatitis E virus (HEV) infection and to characterize HEV genomes among Japanese wild boars (Sus scrofa leucomystax), 578 boars captured in 25 prefectures from 2003 to 2010 were studied. Anti-HEV IgG was detected in 8.1%, and HEV RNA in 3.3% of boars. Among the 19 boar HEV isolates obtained from infected boars, 14 isolates (74%) were classified as genotype 3, 4 isolates (21%) as genotype 4, and the remaining isolate (wbJOY_06) was distantly related to all known HEV isolates of genotypes 1-4, differing by 18.4-25.0% and 18.0-24.3% within the 412-nucleotide sequence of ORF1 and ORF2, respectively. A genotype 4 boar HEV isolate (wbJGF_08-1) obtained herein shared 98.6% identity over the entire genome with a human HEV isolate obtained from a patient who developed acute hepatitis after consuming undercooked wild boar meat, suggesting that wild boars are also reservoirs for genotype 4 HEV in humans.

Authors+Show Affiliations

Kamiichi General Hospital, Kamiichi, Toyama, 930-0391, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21475985

Citation

Sato, Yukihiro, et al. "A Nationwide Survey of Hepatitis E Virus (HEV) Infection in Wild Boars in Japan: Identification of Boar HEV Strains of Genotypes 3 and 4 and Unrecognized Genotypes." Archives of Virology, vol. 156, no. 8, 2011, pp. 1345-58.
Sato Y, Sato H, Naka K, et al. A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes. Arch Virol. 2011;156(8):1345-58.
Sato, Y., Sato, H., Naka, K., Furuya, S., Tsukiji, H., Kitagawa, K., Sonoda, Y., Usui, T., Sakamoto, H., Yoshino, S., Shimizu, Y., Takahashi, M., Nagashima, S., Jirintai, ., Nishizawa, T., & Okamoto, H. (2011). A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes. Archives of Virology, 156(8), 1345-58. https://doi.org/10.1007/s00705-011-0988-x
Sato Y, et al. A Nationwide Survey of Hepatitis E Virus (HEV) Infection in Wild Boars in Japan: Identification of Boar HEV Strains of Genotypes 3 and 4 and Unrecognized Genotypes. Arch Virol. 2011;156(8):1345-58. PubMed PMID: 21475985.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A nationwide survey of hepatitis E virus (HEV) infection in wild boars in Japan: identification of boar HEV strains of genotypes 3 and 4 and unrecognized genotypes. AU - Sato,Yukihiro, AU - Sato,Hiroyuki, AU - Naka,Keisuke, AU - Furuya,Satoshi, AU - Tsukiji,Haruhisa, AU - Kitagawa,Koji, AU - Sonoda,Yoshihide, AU - Usui,Takanobu, AU - Sakamoto,Hirotsugu, AU - Yoshino,Sumi, AU - Shimizu,Yuko, AU - Takahashi,Masaharu, AU - Nagashima,Shigeo, AU - Jirintai,, AU - Nishizawa,Tsutomu, AU - Okamoto,Hiroaki, Y1 - 2011/04/08/ PY - 2011/01/06/received PY - 2011/03/21/accepted PY - 2011/4/9/entrez PY - 2011/4/9/pubmed PY - 2011/9/29/medline SP - 1345 EP - 58 JF - Archives of virology JO - Arch Virol VL - 156 IS - 8 N2 - To investigate the nationwide prevalence of hepatitis E virus (HEV) infection and to characterize HEV genomes among Japanese wild boars (Sus scrofa leucomystax), 578 boars captured in 25 prefectures from 2003 to 2010 were studied. Anti-HEV IgG was detected in 8.1%, and HEV RNA in 3.3% of boars. Among the 19 boar HEV isolates obtained from infected boars, 14 isolates (74%) were classified as genotype 3, 4 isolates (21%) as genotype 4, and the remaining isolate (wbJOY_06) was distantly related to all known HEV isolates of genotypes 1-4, differing by 18.4-25.0% and 18.0-24.3% within the 412-nucleotide sequence of ORF1 and ORF2, respectively. A genotype 4 boar HEV isolate (wbJGF_08-1) obtained herein shared 98.6% identity over the entire genome with a human HEV isolate obtained from a patient who developed acute hepatitis after consuming undercooked wild boar meat, suggesting that wild boars are also reservoirs for genotype 4 HEV in humans. SN - 1432-8798 UR - https://www.unboundmedicine.com/medline/citation/21475985/A_nationwide_survey_of_hepatitis_E_virus__HEV__infection_in_wild_boars_in_Japan:_identification_of_boar_HEV_strains_of_genotypes_3_and_4_and_unrecognized_genotypes_ L2 - https://dx.doi.org/10.1007/s00705-011-0988-x DB - PRIME DP - Unbound Medicine ER -