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Hepatoprotective effect of the aqueous extract of Flemingia macrophylla on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities.
Am J Chin Med 2011; 39(2):349-65AJ

Abstract

This study investigated the protective effect of the aqueous extract of Flemingia macrophylla (AFM) against hepatic injury induced by CCl(4). Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected as biomarkers in the blood to indicate hepatic injury. Product of lipid peroxidation (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and reduced glutathione (GSH) contents were evaluated for oxidative stress in hepatic injury. Moreover, histopathological observation was assayed for the degree of hepatic injury. After oral administration of AFM, 0.5 g/kg and 1.0 g/kg doses significantly decreased ALT and AST, attenuated the histopathology of hepatic injury, ameliorated oxidative stress in hepatic tissue, and increased the activities of CAT, SOD and GSH-Px. The hepatoprotective effect of daidzein and genistein were consistent to that of AFM. This study demonstrated for the first time that AFM has hepatoprotective effect on acute liver injuries induced by CCl(4), and the results suggested that the effect of AFM against CCl(4)-induced liver damage was related to antioxidant properties.

Authors+Show Affiliations

Institute of Chinese Pharmaceutical Sciences, College of Pharmacy, China Medical University, 91 Hsueh-Shih Road, Taichung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21476211

Citation

Hsieh, Po-Chow, et al. "Hepatoprotective Effect of the Aqueous Extract of Flemingia Macrophylla On Carbon Tetrachloride-induced Acute Hepatotoxicity in Rats Through Anti-oxidative Activities." The American Journal of Chinese Medicine, vol. 39, no. 2, 2011, pp. 349-65.
Hsieh PC, Ho YL, Huang GJ, et al. Hepatoprotective effect of the aqueous extract of Flemingia macrophylla on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities. Am J Chin Med. 2011;39(2):349-65.
Hsieh, P. C., Ho, Y. L., Huang, G. J., Huang, M. H., Chiang, Y. C., Huang, S. S., ... Chang, Y. S. (2011). Hepatoprotective effect of the aqueous extract of Flemingia macrophylla on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities. The American Journal of Chinese Medicine, 39(2), pp. 349-65.
Hsieh PC, et al. Hepatoprotective Effect of the Aqueous Extract of Flemingia Macrophylla On Carbon Tetrachloride-induced Acute Hepatotoxicity in Rats Through Anti-oxidative Activities. Am J Chin Med. 2011;39(2):349-65. PubMed PMID: 21476211.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatoprotective effect of the aqueous extract of Flemingia macrophylla on carbon tetrachloride-induced acute hepatotoxicity in rats through anti-oxidative activities. AU - Hsieh,Po-Chow, AU - Ho,Yu-Ling, AU - Huang,Guan-Jhong, AU - Huang,Ming-Hsing, AU - Chiang,Ying-Chen, AU - Huang,Shyh-Shyun, AU - Hou,Wen-Chi, AU - Chang,Yuan-Shiun, PY - 2011/4/9/entrez PY - 2011/4/9/pubmed PY - 2011/10/4/medline SP - 349 EP - 65 JF - The American journal of Chinese medicine JO - Am. J. Chin. Med. VL - 39 IS - 2 N2 - This study investigated the protective effect of the aqueous extract of Flemingia macrophylla (AFM) against hepatic injury induced by CCl(4). Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) were detected as biomarkers in the blood to indicate hepatic injury. Product of lipid peroxidation (MDA), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px), and reduced glutathione (GSH) contents were evaluated for oxidative stress in hepatic injury. Moreover, histopathological observation was assayed for the degree of hepatic injury. After oral administration of AFM, 0.5 g/kg and 1.0 g/kg doses significantly decreased ALT and AST, attenuated the histopathology of hepatic injury, ameliorated oxidative stress in hepatic tissue, and increased the activities of CAT, SOD and GSH-Px. The hepatoprotective effect of daidzein and genistein were consistent to that of AFM. This study demonstrated for the first time that AFM has hepatoprotective effect on acute liver injuries induced by CCl(4), and the results suggested that the effect of AFM against CCl(4)-induced liver damage was related to antioxidant properties. SN - 1793-6853 UR - https://www.unboundmedicine.com/medline/citation/21476211/Hepatoprotective_effect_of_the_aqueous_extract_of_Flemingia_macrophylla_on_carbon_tetrachloride_induced_acute_hepatotoxicity_in_rats_through_anti_oxidative_activities_ L2 - https://www.worldscientific.com/doi/full/10.1142/S0192415X11008877?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -