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Fruit and vegetable intake and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study.
Br J Nutr. 2011 Sep; 106(5):752-61.BJ

Abstract

To postpone cognitive decline and dementia in old age, primary prevention is required earlier in life during middle age. Dietary components may be modifiable determinants of mental performance. In the present study, habitual fruit and vegetable intake was studied in association with cognitive function and cognitive decline during middle age. In the Doetinchem Cohort Study, 2613 men and women aged 43-70 years at baseline (1995-2002) were examined for cognitive function twice, with a 5-year time interval. Global cognitive function and the domains memory, information processing speed and cognitive flexibility were assessed. Dietary intake was assessed with a semi-quantitative FFQ. In multivariate linear regression analyses, habitual fruit and vegetable intake was studied in association with baseline and change in cognitive function. Higher reported vegetable intake was associated with lower information processing speed (P = 0·02) and worse cognitive flexibility (P = 0·03) at baseline, but with smaller decline in information processing speed (P < 0·01) and global cognitive function (P = 0·02) at follow-up. Total intakes of fruits, legumes and juices were not associated with baseline or change in cognitive function. High intakes of some subgroups of fruits and vegetables (i.e. nuts, cabbage and root vegetables) were associated with better cognitive function at baseline and/or smaller decline in cognitive domains. In conclusion, total intake of fruits and vegetables was not or inconsistently associated with cognitive function and cognitive decline. A high habitual consumption of some specific fruits and vegetables may diminish age-related cognitive decline in middle-aged individuals. Further research is needed to verify these findings before recommendations can be made.

Authors+Show Affiliations

National Institute for Public Health and the Environment (RIVM), Postbus 1, 3720 BA Bilthoven, The Netherlands. astrid.nooyens@rivm.nlNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21477405

Citation

Nooyens, Astrid C J., et al. "Fruit and Vegetable Intake and Cognitive Decline in Middle-aged Men and Women: the Doetinchem Cohort Study." The British Journal of Nutrition, vol. 106, no. 5, 2011, pp. 752-61.
Nooyens AC, Bueno-de-Mesquita HB, van Boxtel MP, et al. Fruit and vegetable intake and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. Br J Nutr. 2011;106(5):752-61.
Nooyens, A. C., Bueno-de-Mesquita, H. B., van Boxtel, M. P., van Gelder, B. M., Verhagen, H., & Verschuren, W. M. (2011). Fruit and vegetable intake and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. The British Journal of Nutrition, 106(5), 752-61. https://doi.org/10.1017/S0007114511001024
Nooyens AC, et al. Fruit and Vegetable Intake and Cognitive Decline in Middle-aged Men and Women: the Doetinchem Cohort Study. Br J Nutr. 2011;106(5):752-61. PubMed PMID: 21477405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Fruit and vegetable intake and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. AU - Nooyens,Astrid C J, AU - Bueno-de-Mesquita,H Bas, AU - van Boxtel,Martin P J, AU - van Gelder,Boukje M, AU - Verhagen,Hans, AU - Verschuren,W M Monique, Y1 - 2011/04/11/ PY - 2011/4/12/entrez PY - 2011/4/12/pubmed PY - 2011/10/14/medline SP - 752 EP - 61 JF - The British journal of nutrition JO - Br J Nutr VL - 106 IS - 5 N2 - To postpone cognitive decline and dementia in old age, primary prevention is required earlier in life during middle age. Dietary components may be modifiable determinants of mental performance. In the present study, habitual fruit and vegetable intake was studied in association with cognitive function and cognitive decline during middle age. In the Doetinchem Cohort Study, 2613 men and women aged 43-70 years at baseline (1995-2002) were examined for cognitive function twice, with a 5-year time interval. Global cognitive function and the domains memory, information processing speed and cognitive flexibility were assessed. Dietary intake was assessed with a semi-quantitative FFQ. In multivariate linear regression analyses, habitual fruit and vegetable intake was studied in association with baseline and change in cognitive function. Higher reported vegetable intake was associated with lower information processing speed (P = 0·02) and worse cognitive flexibility (P = 0·03) at baseline, but with smaller decline in information processing speed (P < 0·01) and global cognitive function (P = 0·02) at follow-up. Total intakes of fruits, legumes and juices were not associated with baseline or change in cognitive function. High intakes of some subgroups of fruits and vegetables (i.e. nuts, cabbage and root vegetables) were associated with better cognitive function at baseline and/or smaller decline in cognitive domains. In conclusion, total intake of fruits and vegetables was not or inconsistently associated with cognitive function and cognitive decline. A high habitual consumption of some specific fruits and vegetables may diminish age-related cognitive decline in middle-aged individuals. Further research is needed to verify these findings before recommendations can be made. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/21477405/Fruit_and_vegetable_intake_and_cognitive_decline_in_middle_aged_men_and_women:_the_Doetinchem_Cohort_Study_ L2 - https://www.cambridge.org/core/product/identifier/S0007114511001024/type/journal_article DB - PRIME DP - Unbound Medicine ER -