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Meconium aspiration syndrome - the experience of a tertiary center.
Rev Port Pneumol. 2011 Mar-Apr; 17(2):71-6.RP

Abstract

BACKGROUND

Approximately 5 % of infants born with a meconium-stained amniotic fluid (MSAF) develop meconium aspiration syndrome (MAS).

AIM

The aims of this study were to analyse demographic data, morbidity and mortality associated with MAS and to identify possible risk factors.

METHODS

Retrospective chart review of newborns with MAS delivered at a tertiary centre from January 1st, 1997 to December 31st, 2008.

RESULTS

MAS was responsible for 1.4 % of all Neonatal Intensive Care Unit (NICU) admissions, with a trend towards a decreasing incidence during the study duration, especially in the cases of thin meconium. Seventy two newborns were analysed during the study period: 55.6 % (n = 40) were of the female gender, 62.5 % were delivered by caesarean section, 93 % had > 36 weeks of gestational age and 91.2 % had a birth weight over 2500g. Sixty-nine percent had an Apgar score < 7 at 1 minute and 23.6 % an Apgar score < 7 at 5 minutes; foetal bradicardia was present in 26.4 % of the newborns and tachycardia in 1.4 %. The presence of meconium was associated with severe asphyxia and carried a bad prognosis with an increased risk of developing hypoxia (58.3 %), need of mechanical ventilatory support (43.1 %), respiratory and/or metabolic acidosis (30.6 %), pulmonary hypertension (11.1 %) and hypoxic ischemic encephalopathy (29.2 %). The mortality rate was 2.8 %. Thick meconium was associated with higher morbidity and mortality rates.

CONCLUSION

The number of admissions for MAS has been decreasing mostly because of a lower admission rate due to thin meconium; the number of cases with thick meconium has remained constant throughout the years. An Apgar score < 7 at 1 minute and signs of foetal distress during labour were associated with MAS. The MAS related morbidity remains significant.

Links

Publisher Full Text
elsevier.es
linkinghub.elsevier.com

Authors+Show Affiliations

Espinheira MC
Neonatal Intensive Care Unit, Department of Pediatrics, Hospital São João, Oporto, Portugal.
Grilo M
No affiliation info available
Rocha G
No affiliation info available
Guedes B
No affiliation info available
Guimarães H
No affiliation info available

MeSH

FemaleHumansIncidenceInfant, NewbornMaleMeconium Aspiration SyndromeRetrospective StudiesRisk Factors

Pub Type(s)

Journal Article

Language

eng por

PubMed ID

21477569

Citation

Espinheira, M C., et al. "Meconium Aspiration Syndrome - the Experience of a Tertiary Center." Revista Portuguesa De Pneumologia, vol. 17, no. 2, 2011, pp. 71-6.
Espinheira MC, Grilo M, Rocha G, et al. Meconium aspiration syndrome - the experience of a tertiary center. Rev Port Pneumol. 2011;17(2):71-6.
Espinheira, M. C., Grilo, M., Rocha, G., Guedes, B., & Guimarães, H. (2011). Meconium aspiration syndrome - the experience of a tertiary center. Revista Portuguesa De Pneumologia, 17(2), 71-6.
Espinheira MC, et al. Meconium Aspiration Syndrome - the Experience of a Tertiary Center. Rev Port Pneumol. 2011 Mar-Apr;17(2):71-6. PubMed PMID: 21477569.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meconium aspiration syndrome - the experience of a tertiary center. AU - Espinheira,M C, AU - Grilo,M, AU - Rocha,G, AU - Guedes,B, AU - Guimarães,H, PY - 2011/4/12/entrez PY - 2011/4/12/pubmed PY - 2011/8/31/medline SP - 71 EP - 6 JF - Revista portuguesa de pneumologia JO - Rev Port Pneumol VL - 17 IS - 2 N2 - BACKGROUND: Approximately 5 % of infants born with a meconium-stained amniotic fluid (MSAF) develop meconium aspiration syndrome (MAS). AIM: The aims of this study were to analyse demographic data, morbidity and mortality associated with MAS and to identify possible risk factors. METHODS: Retrospective chart review of newborns with MAS delivered at a tertiary centre from January 1st, 1997 to December 31st, 2008. RESULTS: MAS was responsible for 1.4 % of all Neonatal Intensive Care Unit (NICU) admissions, with a trend towards a decreasing incidence during the study duration, especially in the cases of thin meconium. Seventy two newborns were analysed during the study period: 55.6 % (n = 40) were of the female gender, 62.5 % were delivered by caesarean section, 93 % had > 36 weeks of gestational age and 91.2 % had a birth weight over 2500g. Sixty-nine percent had an Apgar score < 7 at 1 minute and 23.6 % an Apgar score < 7 at 5 minutes; foetal bradicardia was present in 26.4 % of the newborns and tachycardia in 1.4 %. The presence of meconium was associated with severe asphyxia and carried a bad prognosis with an increased risk of developing hypoxia (58.3 %), need of mechanical ventilatory support (43.1 %), respiratory and/or metabolic acidosis (30.6 %), pulmonary hypertension (11.1 %) and hypoxic ischemic encephalopathy (29.2 %). The mortality rate was 2.8 %. Thick meconium was associated with higher morbidity and mortality rates. CONCLUSION: The number of admissions for MAS has been decreasing mostly because of a lower admission rate due to thin meconium; the number of cases with thick meconium has remained constant throughout the years. An Apgar score < 7 at 1 minute and signs of foetal distress during labour were associated with MAS. The MAS related morbidity remains significant. SN - 2172-6825 UR - https://www.unboundmedicine.com/medline/citation/21477569/Meconium_aspiration_syndrome___the_experience_of_a_tertiary_center_ L2 - http://www.elsevier.es/en/linksolver/pdf/pii/90002027 DB - PRIME DP - Unbound Medicine ER -