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Association between serum cobalamin and methylmalonic acid concentrations in dogs.
Vet J. 2012 Mar; 191(3):306-11.VJ

Abstract

The aim of this study was to evaluate the association between serum methylmalonic acid (MMA), a proposed marker of cellular cobalamin deficiency, and serum cobalamin concentrations in dogs. Serum samples from 555 dogs were grouped according to their serum cobalamin concentrations (<150 ng/L to 1000 ng/L). Additionally, serum samples were collected from 43 healthy dogs to calculate a reference interval for canine serum MMA. MMA was measured using a GC/MS method. Groups were compared using a Kruskal-Wallis test with Dunn's post test. Proportions of dogs above the upper limit of the reference interval were calculated and a χ2-test for trend was performed to evaluate the association between serum cobalamin and MMA concentrations. The reference interval for serum MMA was calculated to be 414.7-1192.5 nmol/L. Dogs with serum cobalamin concentrations <251 ng/L had significantly higher MMA concentrations (P<0.05) and the χ2-test for trend showed a trend for increasing serum MMA concentrations with decreasing serum cobalamin concentrations (P<0.0001). Additionally, a number of dogs with normal serum cobalamin concentrations had increased serum MMA concentrations, suggesting that some of these dogs may have cobalamin deficiency on a cellular level. Further studies are warranted to determine if these dogs should receive cobalamin supplementation.

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Authors+Show Affiliations

Berghoff N
Gastrointestinal Laboratory, Department of Small Animal Clinical Sciences, College of Veterinary Medicine and Biomedical Sciences, Texas A&M University, College Station, TX 77843-4474, USA. nberghoff@cvm.tamu.edu
Suchodolski JS
No affiliation info available
Steiner JM
No affiliation info available

MeSH

AnimalsBiomarkersDog DiseasesDogsMethylmalonic AcidVitamin B 12Vitamin B 12 Deficiency

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21478039

Citation

Berghoff, Nora, et al. "Association Between Serum Cobalamin and Methylmalonic Acid Concentrations in Dogs." Veterinary Journal (London, England : 1997), vol. 191, no. 3, 2012, pp. 306-11.
Berghoff N, Suchodolski JS, Steiner JM. Association between serum cobalamin and methylmalonic acid concentrations in dogs. Vet J. 2012;191(3):306-11.
Berghoff, N., Suchodolski, J. S., & Steiner, J. M. (2012). Association between serum cobalamin and methylmalonic acid concentrations in dogs. Veterinary Journal (London, England : 1997), 191(3), 306-11. https://doi.org/10.1016/j.tvjl.2011.03.005
Berghoff N, Suchodolski JS, Steiner JM. Association Between Serum Cobalamin and Methylmalonic Acid Concentrations in Dogs. Vet J. 2012;191(3):306-11. PubMed PMID: 21478039.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association between serum cobalamin and methylmalonic acid concentrations in dogs. AU - Berghoff,Nora, AU - Suchodolski,Jan S, AU - Steiner,Jörg M, Y1 - 2011/04/07/ PY - 2010/10/14/received PY - 2011/01/26/revised PY - 2011/03/07/accepted PY - 2011/4/12/entrez PY - 2011/4/12/pubmed PY - 2012/7/13/medline SP - 306 EP - 11 JF - Veterinary journal (London, England : 1997) JO - Vet J VL - 191 IS - 3 N2 - The aim of this study was to evaluate the association between serum methylmalonic acid (MMA), a proposed marker of cellular cobalamin deficiency, and serum cobalamin concentrations in dogs. Serum samples from 555 dogs were grouped according to their serum cobalamin concentrations (<150 ng/L to 1000 ng/L). Additionally, serum samples were collected from 43 healthy dogs to calculate a reference interval for canine serum MMA. MMA was measured using a GC/MS method. Groups were compared using a Kruskal-Wallis test with Dunn's post test. Proportions of dogs above the upper limit of the reference interval were calculated and a χ2-test for trend was performed to evaluate the association between serum cobalamin and MMA concentrations. The reference interval for serum MMA was calculated to be 414.7-1192.5 nmol/L. Dogs with serum cobalamin concentrations <251 ng/L had significantly higher MMA concentrations (P<0.05) and the χ2-test for trend showed a trend for increasing serum MMA concentrations with decreasing serum cobalamin concentrations (P<0.0001). Additionally, a number of dogs with normal serum cobalamin concentrations had increased serum MMA concentrations, suggesting that some of these dogs may have cobalamin deficiency on a cellular level. Further studies are warranted to determine if these dogs should receive cobalamin supplementation. SN - 1532-2971 UR - https://www.unboundmedicine.com/medline/citation/21478039/Association_between_serum_cobalamin_and_methylmalonic_acid_concentrations_in_dogs_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S1090-0233(11)00105-5 DB - PRIME DP - Unbound Medicine ER -