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Prevalence of driving with blood drug concentrations above proposed new legal limits in Norway: estimations based on drug concentrations in oral fluid.
Forensic Sci Int. 2011 Jul 15; 210(1-3):221-7.FS

Abstract

AIM

To estimate the prevalence of driving with blood drug concentrations above the recently proposed Norwegian legal limits for drugged driving in random traffic. The results from a roadside survey of 10,816 drivers was used as basis for the estimation, and the most prevalent drugs were included.

METHODS

Three approaches were used to estimate the prevalence of drug concentrations above the proposed legal limits in blood based on drug concentrations in oral fluid: comparison with drug concentrations observed in oral fluid and blood in pharmacokinetic studies, estimating the prevalence of drug concentrations in blood by calculating the prevalence of drug concentrations in oral fluid that were larger than the limit in blood multiplied with mean oral fluid/blood ratios, and a mathematical simulation mimicking the relationship between drug concentration distributions in blood and oral fluid for populations of drug users.

RESULTS

In total, alcohol or drugs were detected in 5.7% of the samples of oral fluid from drivers in normal traffic; 3.8% (n=410) were positive for the drugs that we included in the assessment. The estimation of drug concentrations in blood suggested that about 1.5% had concentrations above the proposed legal limits in blood for the studied drugs, which is about 40% of those who were positive for the drugs in oral fluid.

CONCLUSION

The estimated prevalence of driving with concentrations of psychoactive drugs in blood above the proposed legal limits was for illegal drugs 0.4% and for medicinal drugs 1.1%. These may be regarded as minimum estimates as some drugs were not included in the assessment. These prevalences are higher than the prevalence of driving with blood alcohol concentrations above the legal limit of 0.2g/kg in Norway.

Authors+Show Affiliations

Norwegian Institute of Public Health, Division of Forensic Toxicology and Drug Abuse, P.O. Box 4404 Nydalen, 0403 Oslo, Norway. Hallvard.Gjerde@fhi.noNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21482055

Citation

Gjerde, Hallvard, et al. "Prevalence of Driving With Blood Drug Concentrations Above Proposed New Legal Limits in Norway: Estimations Based On Drug Concentrations in Oral Fluid." Forensic Science International, vol. 210, no. 1-3, 2011, pp. 221-7.
Gjerde H, Normann PT, Christophersen AS, et al. Prevalence of driving with blood drug concentrations above proposed new legal limits in Norway: estimations based on drug concentrations in oral fluid. Forensic Sci Int. 2011;210(1-3):221-7.
Gjerde, H., Normann, P. T., Christophersen, A. S., & Mørland, J. (2011). Prevalence of driving with blood drug concentrations above proposed new legal limits in Norway: estimations based on drug concentrations in oral fluid. Forensic Science International, 210(1-3), 221-7. https://doi.org/10.1016/j.forsciint.2011.03.021
Gjerde H, et al. Prevalence of Driving With Blood Drug Concentrations Above Proposed New Legal Limits in Norway: Estimations Based On Drug Concentrations in Oral Fluid. Forensic Sci Int. 2011 Jul 15;210(1-3):221-7. PubMed PMID: 21482055.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevalence of driving with blood drug concentrations above proposed new legal limits in Norway: estimations based on drug concentrations in oral fluid. AU - Gjerde,Hallvard, AU - Normann,Per T, AU - Christophersen,Asbjørg S, AU - Mørland,Jørg, Y1 - 2011/04/08/ PY - 2011/02/01/received PY - 2011/03/07/revised PY - 2011/03/12/accepted PY - 2011/4/13/entrez PY - 2011/4/13/pubmed PY - 2011/11/4/medline SP - 221 EP - 7 JF - Forensic science international JO - Forensic Sci Int VL - 210 IS - 1-3 N2 - AIM: To estimate the prevalence of driving with blood drug concentrations above the recently proposed Norwegian legal limits for drugged driving in random traffic. The results from a roadside survey of 10,816 drivers was used as basis for the estimation, and the most prevalent drugs were included. METHODS: Three approaches were used to estimate the prevalence of drug concentrations above the proposed legal limits in blood based on drug concentrations in oral fluid: comparison with drug concentrations observed in oral fluid and blood in pharmacokinetic studies, estimating the prevalence of drug concentrations in blood by calculating the prevalence of drug concentrations in oral fluid that were larger than the limit in blood multiplied with mean oral fluid/blood ratios, and a mathematical simulation mimicking the relationship between drug concentration distributions in blood and oral fluid for populations of drug users. RESULTS: In total, alcohol or drugs were detected in 5.7% of the samples of oral fluid from drivers in normal traffic; 3.8% (n=410) were positive for the drugs that we included in the assessment. The estimation of drug concentrations in blood suggested that about 1.5% had concentrations above the proposed legal limits in blood for the studied drugs, which is about 40% of those who were positive for the drugs in oral fluid. CONCLUSION: The estimated prevalence of driving with concentrations of psychoactive drugs in blood above the proposed legal limits was for illegal drugs 0.4% and for medicinal drugs 1.1%. These may be regarded as minimum estimates as some drugs were not included in the assessment. These prevalences are higher than the prevalence of driving with blood alcohol concentrations above the legal limit of 0.2g/kg in Norway. SN - 1872-6283 UR - https://www.unboundmedicine.com/medline/citation/21482055/Prevalence_of_driving_with_blood_drug_concentrations_above_proposed_new_legal_limits_in_Norway:_estimations_based_on_drug_concentrations_in_oral_fluid_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0379-0738(11)00148-4 DB - PRIME DP - Unbound Medicine ER -