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Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease.

Abstract

OBJECTIVE

Inflammatory bowel disease (IBD) is a chronic inflammatory process in the digestive tract and patients with IBD develop osteopenia. Although vitamins K and D are important for maintaining bone health and inhibiting inflammation, their roles in patients with IBD are not clear. We investigated the roles of vitamins K and D in the bone health and inflammation in patients with IBD.

METHODS

Bone mineral density (BMD) of patients with IBD (Crohn's disease [CD], n = 47, and ulcerative colitis [UC], n = 40) was measured with dual-energy X-ray absorptiometry. Vitamin K and D levels of patients with IBD and healthy volunteers (n = 41) were evaluated by measuring serum undercarboxylated osteocalcin and 1,25 dihydroxyvitamin D, respectively. Clinical activity index was evaluated in patients with CD and UC.

RESULTS

BMD was low in patients with CD and UC. Serum undercarboxylated osteocalcin levels were significantly higher in patients with CD, but not with UC, compared with healthy subjects, indicating that bone vitamin K is insufficient in patients with CD. The levels of undercarboxylated osteocalcin were significantly correlated with the clinical activity index of CD, although they were not correlated with BMD. The levels of 1,25 dihydroxyvitamin D were significantly lower in patients with CD and UC than in healthy subjects. The levels of 1,25 dihydroxyvitamin D were inversely correlated with BMD in patients with UC and were not correlated with the clinical activity index of CD.

CONCLUSION

Vitamins K and D are insufficient in patients with IBD. Insufficiency of vitamin K is suggested to be associated with inflammatory processes of CD.

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  • Authors+Show Affiliations

    ,

    Department of Gastroenterology and Hepatology, Osaka University Graduate School of Medicine, Suita, Osaka, Japan.

    , , , , , , , , , , , ,

    Source

    MeSH

    Adult
    Bone Density
    Bone and Bones
    Colitis, Ulcerative
    Crohn Disease
    Female
    Humans
    Hydroxycholecalciferols
    Male
    Middle Aged
    Osteocalcin
    Vitamin D Deficiency
    Vitamin K Deficiency

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21482072

    Citation

    Nakajima, Sachiko, et al. "Association of Vitamin K Deficiency With Bone Metabolism and Clinical Disease Activity in Inflammatory Bowel Disease." Nutrition (Burbank, Los Angeles County, Calif.), vol. 27, no. 10, 2011, pp. 1023-8.
    Nakajima S, Iijima H, Egawa S, et al. Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease. Nutrition. 2011;27(10):1023-8.
    Nakajima, S., Iijima, H., Egawa, S., Shinzaki, S., Kondo, J., Inoue, T., ... Hayashi, N. (2011). Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease. Nutrition (Burbank, Los Angeles County, Calif.), 27(10), pp. 1023-8. doi:10.1016/j.nut.2010.10.021.
    Nakajima S, et al. Association of Vitamin K Deficiency With Bone Metabolism and Clinical Disease Activity in Inflammatory Bowel Disease. Nutrition. 2011;27(10):1023-8. PubMed PMID: 21482072.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Association of vitamin K deficiency with bone metabolism and clinical disease activity in inflammatory bowel disease. AU - Nakajima,Sachiko, AU - Iijima,Hideki, AU - Egawa,Satoshi, AU - Shinzaki,Shinichiro, AU - Kondo,Jumpei, AU - Inoue,Takahiro, AU - Hayashi,Yoshito, AU - Ying,Jin, AU - Mukai,Akira, AU - Akasaka,Tomofumi, AU - Nishida,Tsutomu, AU - Kanto,Tatsuya, AU - Tsujii,Masahiko, AU - Hayashi,Norio, Y1 - 2011/04/09/ PY - 2010/01/30/received PY - 2010/09/08/revised PY - 2010/10/28/accepted PY - 2011/4/13/entrez PY - 2011/4/13/pubmed PY - 2012/3/7/medline SP - 1023 EP - 8 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 27 IS - 10 N2 - OBJECTIVE: Inflammatory bowel disease (IBD) is a chronic inflammatory process in the digestive tract and patients with IBD develop osteopenia. Although vitamins K and D are important for maintaining bone health and inhibiting inflammation, their roles in patients with IBD are not clear. We investigated the roles of vitamins K and D in the bone health and inflammation in patients with IBD. METHODS: Bone mineral density (BMD) of patients with IBD (Crohn's disease [CD], n = 47, and ulcerative colitis [UC], n = 40) was measured with dual-energy X-ray absorptiometry. Vitamin K and D levels of patients with IBD and healthy volunteers (n = 41) were evaluated by measuring serum undercarboxylated osteocalcin and 1,25 dihydroxyvitamin D, respectively. Clinical activity index was evaluated in patients with CD and UC. RESULTS: BMD was low in patients with CD and UC. Serum undercarboxylated osteocalcin levels were significantly higher in patients with CD, but not with UC, compared with healthy subjects, indicating that bone vitamin K is insufficient in patients with CD. The levels of undercarboxylated osteocalcin were significantly correlated with the clinical activity index of CD, although they were not correlated with BMD. The levels of 1,25 dihydroxyvitamin D were significantly lower in patients with CD and UC than in healthy subjects. The levels of 1,25 dihydroxyvitamin D were inversely correlated with BMD in patients with UC and were not correlated with the clinical activity index of CD. CONCLUSION: Vitamins K and D are insufficient in patients with IBD. Insufficiency of vitamin K is suggested to be associated with inflammatory processes of CD. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/21482072/Association_of_vitamin_K_deficiency_with_bone_metabolism_and_clinical_disease_activity_in_inflammatory_bowel_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(10)00400-4 DB - PRIME DP - Unbound Medicine ER -