Tags

Type your tag names separated by a space and hit enter

SUMO and its role in human diseases.
Int Rev Cell Mol Biol. 2011; 288:167-83.IR

Abstract

The covalent attachment of small ubiquition-like modifier (SUMO) polypeptides, or sumoylation, is an important regulator of the functional properties of many proteins. Among these are many proteins implicated in human diseases including cancer and Huntington's, Alzheimer's, and Parkinson's diseases, as well as spinocerebellar ataxia 1 and amyotrophic lateral sclerosis. The results of two more recent studies identify two additional human disease-associated proteins that are sumoylated, amyloid precursor protein (APP), and lamin A. APP sumoylation modulates Aβ peptide levels, suggesting a potential role in Alzheimer's disease, and decreased lamin A sumoylation due to mutations near its SUMO site has been implicated in causing some forms of familial dilated cardiomyopathy.

Authors+Show Affiliations

Department of Molecular and Cellular Biochemistry, University of Kentucky, Lexington, Kentucky, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

21482412

Citation

Sarge, Kevin D., and Ok-Kyong Park-Sarge. "SUMO and Its Role in Human Diseases." International Review of Cell and Molecular Biology, vol. 288, 2011, pp. 167-83.
Sarge KD, Park-Sarge OK. SUMO and its role in human diseases. Int Rev Cell Mol Biol. 2011;288:167-83.
Sarge, K. D., & Park-Sarge, O. K. (2011). SUMO and its role in human diseases. International Review of Cell and Molecular Biology, 288, 167-83. https://doi.org/10.1016/B978-0-12-386041-5.00004-2
Sarge KD, Park-Sarge OK. SUMO and Its Role in Human Diseases. Int Rev Cell Mol Biol. 2011;288:167-83. PubMed PMID: 21482412.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - SUMO and its role in human diseases. AU - Sarge,Kevin D, AU - Park-Sarge,Ok-Kyong, PY - 2011/4/13/entrez PY - 2011/4/13/pubmed PY - 2011/7/23/medline SP - 167 EP - 83 JF - International review of cell and molecular biology JO - Int Rev Cell Mol Biol VL - 288 N2 - The covalent attachment of small ubiquition-like modifier (SUMO) polypeptides, or sumoylation, is an important regulator of the functional properties of many proteins. Among these are many proteins implicated in human diseases including cancer and Huntington's, Alzheimer's, and Parkinson's diseases, as well as spinocerebellar ataxia 1 and amyotrophic lateral sclerosis. The results of two more recent studies identify two additional human disease-associated proteins that are sumoylated, amyloid precursor protein (APP), and lamin A. APP sumoylation modulates Aβ peptide levels, suggesting a potential role in Alzheimer's disease, and decreased lamin A sumoylation due to mutations near its SUMO site has been implicated in causing some forms of familial dilated cardiomyopathy. SN - 1937-6448 UR - https://www.unboundmedicine.com/medline/citation/21482412/SUMO_and_its_role_in_human_diseases_ L2 - https://linkinghub.elsevier.com/retrieve/pii/B9780123860415000042 DB - PRIME DP - Unbound Medicine ER -