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[Anti-NMDA receptor paraneoplastic encephalitis: complete recovery after ovarian teratoma removal].
Rev Neurol. 2011 May 01; 52(9):536-40.RN

Abstract

INTRODUCTION

A paraneoplastic syndrome characterized by neuropsychiatric symptoms, involuntary movements and seizures has been recently associated with antibodies targeting NMDA (N-methyl-D-aspartate) receptor in patients with an ovarian teratoma. Severe neurological impairment is frequent and treatment in the intensive care unit is often required because of ventilatory failure and life-threatening autonomic instability. Tumor removal is curative in many cases and neurological improvement is demonstrated shortly after surgery.

CASE REPORT

Here we report on a patient with paraneoplastic encephalitis manifested by unconsciousness and coreo-athetosic movements related to NMDA receptor antibodies associated with an immature ovarian teratoma grade III. She made a complete recovery after oophorectomy, intravenous immunoglobulin and corticosteroids.

CONCLUSIONS

Treatment of paraneoplastic syndromes is based on specific therapy for underlying tumor associated to immunomodulators. As in this case, anti-NMDA encephalitis may significantly improve after tumor removal and intra-venous immunoglobuline.

Authors+Show Affiliations

Facultad de Medicina, Universidad de Antioquia, Departamento de Neurología Clínica, Medellín, Colombia. germanreyes77@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

spa

PubMed ID

21484725

Citation

Reyes-Botero, Germán, et al. "[Anti-NMDA Receptor Paraneoplastic Encephalitis: Complete Recovery After Ovarian Teratoma Removal]." Revista De Neurologia, vol. 52, no. 9, 2011, pp. 536-40.
Reyes-Botero G, Uribe CS, Hernandez-Ortiz OE, et al. [Anti-NMDA receptor paraneoplastic encephalitis: complete recovery after ovarian teratoma removal]. Rev Neurol. 2011;52(9):536-40.
Reyes-Botero, G., Uribe, C. S., Hernandez-Ortiz, O. E., Ciro, J., Guerra, A., & Dalmau-Obrador, J. (2011). [Anti-NMDA receptor paraneoplastic encephalitis: complete recovery after ovarian teratoma removal]. Revista De Neurologia, 52(9), 536-40.
Reyes-Botero G, et al. [Anti-NMDA Receptor Paraneoplastic Encephalitis: Complete Recovery After Ovarian Teratoma Removal]. Rev Neurol. 2011 May 1;52(9):536-40. PubMed PMID: 21484725.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Anti-NMDA receptor paraneoplastic encephalitis: complete recovery after ovarian teratoma removal]. AU - Reyes-Botero,Germán, AU - Uribe,Carlos S, AU - Hernandez-Ortiz,Olga E, AU - Ciro,Juan, AU - Guerra,Alejandro, AU - Dalmau-Obrador,Josep, PY - 2011/4/13/entrez PY - 2011/4/13/pubmed PY - 2011/8/16/medline SP - 536 EP - 40 JF - Revista de neurologia JO - Rev Neurol VL - 52 IS - 9 N2 - INTRODUCTION: A paraneoplastic syndrome characterized by neuropsychiatric symptoms, involuntary movements and seizures has been recently associated with antibodies targeting NMDA (N-methyl-D-aspartate) receptor in patients with an ovarian teratoma. Severe neurological impairment is frequent and treatment in the intensive care unit is often required because of ventilatory failure and life-threatening autonomic instability. Tumor removal is curative in many cases and neurological improvement is demonstrated shortly after surgery. CASE REPORT: Here we report on a patient with paraneoplastic encephalitis manifested by unconsciousness and coreo-athetosic movements related to NMDA receptor antibodies associated with an immature ovarian teratoma grade III. She made a complete recovery after oophorectomy, intravenous immunoglobulin and corticosteroids. CONCLUSIONS: Treatment of paraneoplastic syndromes is based on specific therapy for underlying tumor associated to immunomodulators. As in this case, anti-NMDA encephalitis may significantly improve after tumor removal and intra-venous immunoglobuline. SN - 1576-6578 UR - https://www.unboundmedicine.com/medline/citation/21484725/[Anti_NMDA_receptor_paraneoplastic_encephalitis:_complete_recovery_after_ovarian_teratoma_removal]_ DB - PRIME DP - Unbound Medicine ER -