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A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials.
Mov Disord. 2011 Apr; 26(5):775-83.MD

Abstract

The neurodegenerative process is well established in Parkinson patients presenting to a physician with early motor signs. There is increasing evidence that a variety of nonmotor features can antedate the typical presentation by many years. As the search for successful disease-modifying treatment advances, it is logical to consider how this could be applied to patients in the earliest stages of the disease, indeed before motor features develop, with the obvious goal of delaying and even preventing the onset of the motor syndrome. However, many of these nonmotor symptoms are rather nonspecific and are not uncommon in the general population. Being able to identify individuals in whom these features are more likely to represent true premotor Parkinson's disease represents a major challenge. Until widely applicable and reliable biomarkers for the presence of Parkinson's disease-related pathology are developed (including biomarkers of disease severity and rate of progression), further evaluation of possible premotor features in selected populations will probably serve as the basis for future studies of disease-modifying therapies. This article will review the current status of premotor symptoms of Parkinson's disease and discuss their potential for early diagnosis and the design of neuroprotective trials.

Authors+Show Affiliations

University of Toronto, Toronto, Ontario, Canada. lang@uhnres.utoronto.ca

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

21484865

Citation

Lang, Anthony E.. "A Critical Appraisal of the Premotor Symptoms of Parkinson's Disease: Potential Usefulness in Early Diagnosis and Design of Neuroprotective Trials." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 26, no. 5, 2011, pp. 775-83.
Lang AE. A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials. Mov Disord. 2011;26(5):775-83.
Lang, A. E. (2011). A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials. Movement Disorders : Official Journal of the Movement Disorder Society, 26(5), 775-83. https://doi.org/10.1002/mds.23609
Lang AE. A Critical Appraisal of the Premotor Symptoms of Parkinson's Disease: Potential Usefulness in Early Diagnosis and Design of Neuroprotective Trials. Mov Disord. 2011;26(5):775-83. PubMed PMID: 21484865.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A critical appraisal of the premotor symptoms of Parkinson's disease: potential usefulness in early diagnosis and design of neuroprotective trials. A1 - Lang,Anthony E, Y1 - 2011/04/11/ PY - 2010/07/19/received PY - 2010/11/12/revised PY - 2010/11/29/accepted PY - 2011/4/13/entrez PY - 2011/4/13/pubmed PY - 2011/8/25/medline SP - 775 EP - 83 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 26 IS - 5 N2 - The neurodegenerative process is well established in Parkinson patients presenting to a physician with early motor signs. There is increasing evidence that a variety of nonmotor features can antedate the typical presentation by many years. As the search for successful disease-modifying treatment advances, it is logical to consider how this could be applied to patients in the earliest stages of the disease, indeed before motor features develop, with the obvious goal of delaying and even preventing the onset of the motor syndrome. However, many of these nonmotor symptoms are rather nonspecific and are not uncommon in the general population. Being able to identify individuals in whom these features are more likely to represent true premotor Parkinson's disease represents a major challenge. Until widely applicable and reliable biomarkers for the presence of Parkinson's disease-related pathology are developed (including biomarkers of disease severity and rate of progression), further evaluation of possible premotor features in selected populations will probably serve as the basis for future studies of disease-modifying therapies. This article will review the current status of premotor symptoms of Parkinson's disease and discuss their potential for early diagnosis and the design of neuroprotective trials. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/21484865/A_critical_appraisal_of_the_premotor_symptoms_of_Parkinson's_disease:_potential_usefulness_in_early_diagnosis_and_design_of_neuroprotective_trials_ L2 - https://doi.org/10.1002/mds.23609 DB - PRIME DP - Unbound Medicine ER -