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Synthesis and anti-microbial evaluation of some novel 1,2,4-triazole derivatives.
Acta Pol Pharm. 2011 Mar-Apr; 68(2):213-21.AP

Abstract

Triazoles with different substituent groups are found to possess diverse applications in the field of medicine and industry. A series of 4-(substituted ethanoyl)amino-3-mercapto-5-(4-nitro)phenyl-1,2,4-triazoles (NU-1 to NU-15) were synthesized as novel antimicrobial agents starting from 4-nitrobenzoic acid. The chemical structures of these newly synthesized compounds were elucidated by IR, 1H NMR, 13C NMR, FAB+ -MS spectral data and elemental analysis. Their antimicrobial activities against Staphylococcus aureus (ATCC-25923), Pseudomonas aeruginosa (ATCC-27853), Escherichia coli (ATCC-8739), Bacillus substilis (ATCC-6633), Candida albicans (MTCC-227), Aspergillus niger (MTCC-3323) and Fusarium oxysporum (MTCC-2087) were investigated.

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Authors+Show Affiliations

Upmanyu N
Pharmaceutical Chemistry Division, Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar (MP)-470003, India. neerajupmanyu2007@gmail.com
Kumar S
No affiliation info available
Kharya MD
No affiliation info available
Shah K
No affiliation info available
Mishra P
No affiliation info available

MeSH

Anti-Infective AgentsBacteriaDisk Diffusion Antimicrobial TestsMagnetic Resonance SpectroscopyMicrobial Sensitivity TestsMitosporic FungiMolecular StructureSpectrometry, Mass, Fast Atom BombardmentSpectrophotometry, InfraredStructure-Activity RelationshipTriazoles

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21485294

Citation

Upmanyu, Neeraj, et al. "Synthesis and Anti-microbial Evaluation of some Novel 1,2,4-triazole Derivatives." Acta Poloniae Pharmaceutica, vol. 68, no. 2, 2011, pp. 213-21.
Upmanyu N, Kumar S, Kharya MD, et al. Synthesis and anti-microbial evaluation of some novel 1,2,4-triazole derivatives. Acta Pol Pharm. 2011;68(2):213-21.
Upmanyu, N., Kumar, S., Kharya, M. D., Shah, K., & Mishra, P. (2011). Synthesis and anti-microbial evaluation of some novel 1,2,4-triazole derivatives. Acta Poloniae Pharmaceutica, 68(2), 213-21.
Upmanyu N, et al. Synthesis and Anti-microbial Evaluation of some Novel 1,2,4-triazole Derivatives. Acta Pol Pharm. 2011 Mar-Apr;68(2):213-21. PubMed PMID: 21485294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Synthesis and anti-microbial evaluation of some novel 1,2,4-triazole derivatives. AU - Upmanyu,Neeraj, AU - Kumar,Sanjay, AU - Kharya,Murali-Dhar, AU - Shah,Kamal, AU - Mishra,Praadep, PY - 2011/4/13/entrez PY - 2011/4/13/pubmed PY - 2011/5/12/medline SP - 213 EP - 21 JF - Acta poloniae pharmaceutica JO - Acta Pol Pharm VL - 68 IS - 2 N2 - Triazoles with different substituent groups are found to possess diverse applications in the field of medicine and industry. A series of 4-(substituted ethanoyl)amino-3-mercapto-5-(4-nitro)phenyl-1,2,4-triazoles (NU-1 to NU-15) were synthesized as novel antimicrobial agents starting from 4-nitrobenzoic acid. The chemical structures of these newly synthesized compounds were elucidated by IR, 1H NMR, 13C NMR, FAB+ -MS spectral data and elemental analysis. Their antimicrobial activities against Staphylococcus aureus (ATCC-25923), Pseudomonas aeruginosa (ATCC-27853), Escherichia coli (ATCC-8739), Bacillus substilis (ATCC-6633), Candida albicans (MTCC-227), Aspergillus niger (MTCC-3323) and Fusarium oxysporum (MTCC-2087) were investigated. SN - 0001-6837 UR - https://www.unboundmedicine.com/medline/citation/21485294/Synthesis_and_anti_microbial_evaluation_of_some_novel_124_triazole_derivatives_ L2 - http://www.ptfarm.pl/pub/File/Acta_Poloniae/2011/2/213.pdf DB - PRIME DP - Unbound Medicine ER -