Tags

Type your tag names separated by a space and hit enter

Adverse effects of TiO2 and ZnO nanoparticles in soil nematode, Caenorhabditis elegans.
J Biomed Nanotechnol. 2011 Feb; 7(1):116-7.JB

Abstract

During the last decade, advancement of nanotechnology has revolutionized various fields such as electronics, optics, materials science as well as architecture, and medicine. However, their health and environmental impact is not fully understood. TiO2 and ZnO nanoparticles (NPs), which are abundantly used for commercial purposes, pose a great risk to environment. In this context, we examined the adverse effects of TiO2 and ZnO NPs of < 25 nm and < 100 nm sizes to nematode Caenorhabditis elegans. < 25 nm TiO2 and ZnO NPs showed LC50 of 77 mg/L and 0.32 mg/L respectively, while < 100 nm TiO2 NPs were non-toxic and LC50 of 2 mg/L was obtained for < 100 nm ZnO NPs. Our studies indicate that in both cases, smaller particle sizes are more toxic than larger NPs and ZnO NPs are more toxic than TiO2 NPs. Further, we observed low LC50 values for ZnO NPs, probably reflecting the sensitivity of C. elegans as a model for eco-toxicity studies of NPs.

Authors+Show Affiliations

Khare P
Nanomaterial Toxicology Group, Indian Institute of Toxicology Research (CSIR), P.O. Box 80, Mahatma Gandhi Marg, Lucknow 226001, India.
Sonane M
No affiliation info available
Pandey R
No affiliation info available
Ali S
No affiliation info available
Gupta KC
No affiliation info available
Satish A
No affiliation info available

MeSH

AnimalsCaenorhabditis elegansLethal Dose 50NanoparticlesSurvivalSurvival AnalysisSurvival RateTitaniumZinc Oxide

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21485831

Citation

Khare, Priyanka, et al. "Adverse Effects of TiO2 and ZnO Nanoparticles in Soil Nematode, Caenorhabditis Elegans." Journal of Biomedical Nanotechnology, vol. 7, no. 1, 2011, pp. 116-7.
Khare P, Sonane M, Pandey R, et al. Adverse effects of TiO2 and ZnO nanoparticles in soil nematode, Caenorhabditis elegans. J Biomed Nanotechnol. 2011;7(1):116-7.
Khare, P., Sonane, M., Pandey, R., Ali, S., Gupta, K. C., & Satish, A. (2011). Adverse effects of TiO2 and ZnO nanoparticles in soil nematode, Caenorhabditis elegans. Journal of Biomedical Nanotechnology, 7(1), 116-7.
Khare P, et al. Adverse Effects of TiO2 and ZnO Nanoparticles in Soil Nematode, Caenorhabditis Elegans. J Biomed Nanotechnol. 2011;7(1):116-7. PubMed PMID: 21485831.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adverse effects of TiO2 and ZnO nanoparticles in soil nematode, Caenorhabditis elegans. AU - Khare,Priyanka, AU - Sonane,Madhavi, AU - Pandey,Rakesh, AU - Ali,Shakir, AU - Gupta,Kailash C, AU - Satish,Aruna, PY - 2011/4/14/entrez PY - 2011/4/14/pubmed PY - 2011/6/2/medline SP - 116 EP - 7 JF - Journal of biomedical nanotechnology JO - J Biomed Nanotechnol VL - 7 IS - 1 N2 - During the last decade, advancement of nanotechnology has revolutionized various fields such as electronics, optics, materials science as well as architecture, and medicine. However, their health and environmental impact is not fully understood. TiO2 and ZnO nanoparticles (NPs), which are abundantly used for commercial purposes, pose a great risk to environment. In this context, we examined the adverse effects of TiO2 and ZnO NPs of < 25 nm and < 100 nm sizes to nematode Caenorhabditis elegans. < 25 nm TiO2 and ZnO NPs showed LC50 of 77 mg/L and 0.32 mg/L respectively, while < 100 nm TiO2 NPs were non-toxic and LC50 of 2 mg/L was obtained for < 100 nm ZnO NPs. Our studies indicate that in both cases, smaller particle sizes are more toxic than larger NPs and ZnO NPs are more toxic than TiO2 NPs. Further, we observed low LC50 values for ZnO NPs, probably reflecting the sensitivity of C. elegans as a model for eco-toxicity studies of NPs. SN - 1550-7033 UR - https://www.unboundmedicine.com/medline/citation/21485831/Adverse_effects_of_TiO2_and_ZnO_nanoparticles_in_soil_nematode_Caenorhabditis_elegans_ DB - PRIME DP - Unbound Medicine ER -