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Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone children.
Pediatr Infect Dis J. 2011 Aug; 30(8):645-50.PI

Abstract

BACKGROUND

Streptococcus pneumoniae (Spn) is one of the common bacteria responsible for episodic acute otitis media (AOM; non-otitis-prone), recurrent AOM (otitis-prone), and AOM treatment failure (AOMTF) in children.

OBJECTIVE

From a population of 268 children, we sought to compare the serum IgG antibody titers of 5 different Spn proteins (PhtD, LytB, PcpA, PhtE, and Ply) that are vaccine candidates in children with episodic AOM (n = 34), who were otitis prone (n = 35) and who had AOMTF (n = 25) caused by Spn.

METHODS

Antibody was quantitated by enzyme-linked immunosorbent assay.

RESULTS

At their AOM visit, anti-PhtD, -LytB, -PhtE, and -Ply IgG antibody titers in otitis-prone children were significantly lower compared with non-otitis-prone children (P < 0.05) and children with AOMTF (P < 0.05). On comparing acute to convalescent geometric mean IgG antibody titers after AOM against the 5 proteins we found that otitis-prone, AOMTF, and non-otitis-prone children had no significant change in titers (except for PhtE in children with AOMTF), but detailed analysis showed that about one-third of the children in each cohort had a 2-fold rise in antibody to the studied antigens. Although non-otitis-prone children had significant increases (P < 0.001) between 6 and 24 months of age in anti-PhtD, PcpA, PhtE, and Ply IgG antibody titers as a consequence of nasopharyngeal colonization and AOM, otitis-prone children either failed to show rises or the rises were significantly less than the non-otitis-prone children.

CONCLUSION

Otitis-prone and AOMTF children mount less of an IgG serum antibody response as compared with non-otitis-prone children to Spn proteins after AOM and nasopharyngeal colonization.

Authors+Show Affiliations

Rochester General Hospital Research Institute, Center for Infectious Diseases and Immunology, Rochester, NY 14621, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21487325

Citation

Kaur, Ravinder, et al. "Serum Antibody Response to Five Streptococcus Pneumoniae Proteins During Acute Otitis Media in Otitis-prone and Non-otitis-prone Children." The Pediatric Infectious Disease Journal, vol. 30, no. 8, 2011, pp. 645-50.
Kaur R, Casey JR, Pichichero ME. Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone children. Pediatr Infect Dis J. 2011;30(8):645-50.
Kaur, R., Casey, J. R., & Pichichero, M. E. (2011). Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone children. The Pediatric Infectious Disease Journal, 30(8), 645-50. https://doi.org/10.1097/INF.0b013e31821c2d8b
Kaur R, Casey JR, Pichichero ME. Serum Antibody Response to Five Streptococcus Pneumoniae Proteins During Acute Otitis Media in Otitis-prone and Non-otitis-prone Children. Pediatr Infect Dis J. 2011;30(8):645-50. PubMed PMID: 21487325.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Serum antibody response to five Streptococcus pneumoniae proteins during acute otitis media in otitis-prone and non-otitis-prone children. AU - Kaur,Ravinder, AU - Casey,Janet R, AU - Pichichero,Michael E, PY - 2011/4/14/entrez PY - 2011/4/14/pubmed PY - 2011/11/1/medline SP - 645 EP - 50 JF - The Pediatric infectious disease journal JO - Pediatr Infect Dis J VL - 30 IS - 8 N2 - BACKGROUND: Streptococcus pneumoniae (Spn) is one of the common bacteria responsible for episodic acute otitis media (AOM; non-otitis-prone), recurrent AOM (otitis-prone), and AOM treatment failure (AOMTF) in children. OBJECTIVE: From a population of 268 children, we sought to compare the serum IgG antibody titers of 5 different Spn proteins (PhtD, LytB, PcpA, PhtE, and Ply) that are vaccine candidates in children with episodic AOM (n = 34), who were otitis prone (n = 35) and who had AOMTF (n = 25) caused by Spn. METHODS: Antibody was quantitated by enzyme-linked immunosorbent assay. RESULTS: At their AOM visit, anti-PhtD, -LytB, -PhtE, and -Ply IgG antibody titers in otitis-prone children were significantly lower compared with non-otitis-prone children (P < 0.05) and children with AOMTF (P < 0.05). On comparing acute to convalescent geometric mean IgG antibody titers after AOM against the 5 proteins we found that otitis-prone, AOMTF, and non-otitis-prone children had no significant change in titers (except for PhtE in children with AOMTF), but detailed analysis showed that about one-third of the children in each cohort had a 2-fold rise in antibody to the studied antigens. Although non-otitis-prone children had significant increases (P < 0.001) between 6 and 24 months of age in anti-PhtD, PcpA, PhtE, and Ply IgG antibody titers as a consequence of nasopharyngeal colonization and AOM, otitis-prone children either failed to show rises or the rises were significantly less than the non-otitis-prone children. CONCLUSION: Otitis-prone and AOMTF children mount less of an IgG serum antibody response as compared with non-otitis-prone children to Spn proteins after AOM and nasopharyngeal colonization. SN - 1532-0987 UR - https://www.unboundmedicine.com/medline/citation/21487325/Serum_antibody_response_to_five_Streptococcus_pneumoniae_proteins_during_acute_otitis_media_in_otitis_prone_and_non_otitis_prone_children_ L2 - https://doi.org/10.1097/INF.0b013e31821c2d8b DB - PRIME DP - Unbound Medicine ER -