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A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving.
Psychopharmacology (Berl). 2011 Oct; 217(3):341-51.P

Abstract

RATIONALE

The available treatments for alcoholism are only modestly effective, and patients vary widely in their treatment response. Quetiapine, an atypical antipsychotic medication with antagonist activity at D1 and D2, 5-HT(1A) and 5-HT(2A), H(1), and α1 and α2 receptors was shown to promote abstinence, reduce drinking days, and reduce heavy drinking days in a 12-week double-blind placebo-controlled trial.

OBJECTIVE

Although quetiapine represents one of the promising pharmacotherapies for the treatment of alcoholism, its mechanisms of action are poorly understood. The objective of this study is to elucidate the biobehavioral mechanisms of action of quetiapine for alcoholism, by examining its effects on subjective intoxication and craving.

METHOD

A total of 20 non-treatment-seeking alcohol-dependent individuals were randomized to one of the following conditions in a double-blind, placebo-controlled design: (1) quetiapine (400 mg/day); or (2) matched placebo. Participants were on the target medication dose (or matched placebo) for 4 weeks during which they completed weekly assessments of drinking, sleep, mood, and anxiety. Participants completed two counterbalanced intravenous placebo-alcohol administration sessions as well as cue-reactivity assessments.

RESULTS

Analyses revealed a significant effect of quetiapine in reducing craving during the alcohol administration, the alcohol cue-exposure, and the weekly reports of alcohol craving. Quetiapine was also found to reduce subjective intoxication and alcohol-induced sedation during the alcohol administration paradigm.

CONCLUSIONS

This study contributes critical new information about mechanisms of response to quetiapine for alcoholism, which, in turn, can inform larger-scale studies and ultimately, clinical practice.

Authors+Show Affiliations

Department of Psychology, University of California Los Angeles, 1285 Franz Hall, Box 951563, Los Angeles, CA 90095-1563, USA. lararay@psych.ucla.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial, Phase II
Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21487653

Citation

Ray, Lara A., et al. "A Human Laboratory Study of the Effects of Quetiapine On Subjective Intoxication and Alcohol Craving." Psychopharmacology, vol. 217, no. 3, 2011, pp. 341-51.
Ray LA, Chin PF, Heydari A, et al. A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving. Psychopharmacology (Berl). 2011;217(3):341-51.
Ray, L. A., Chin, P. F., Heydari, A., & Miotto, K. (2011). A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving. Psychopharmacology, 217(3), 341-51. https://doi.org/10.1007/s00213-011-2287-3
Ray LA, et al. A Human Laboratory Study of the Effects of Quetiapine On Subjective Intoxication and Alcohol Craving. Psychopharmacology (Berl). 2011;217(3):341-51. PubMed PMID: 21487653.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A human laboratory study of the effects of quetiapine on subjective intoxication and alcohol craving. AU - Ray,Lara A, AU - Chin,Pauline F, AU - Heydari,Andia, AU - Miotto,Karen, Y1 - 2011/04/13/ PY - 2010/12/20/received PY - 2011/03/25/accepted PY - 2011/4/14/entrez PY - 2011/4/14/pubmed PY - 2012/2/1/medline SP - 341 EP - 51 JF - Psychopharmacology JO - Psychopharmacology (Berl) VL - 217 IS - 3 N2 - RATIONALE: The available treatments for alcoholism are only modestly effective, and patients vary widely in their treatment response. Quetiapine, an atypical antipsychotic medication with antagonist activity at D1 and D2, 5-HT(1A) and 5-HT(2A), H(1), and α1 and α2 receptors was shown to promote abstinence, reduce drinking days, and reduce heavy drinking days in a 12-week double-blind placebo-controlled trial. OBJECTIVE: Although quetiapine represents one of the promising pharmacotherapies for the treatment of alcoholism, its mechanisms of action are poorly understood. The objective of this study is to elucidate the biobehavioral mechanisms of action of quetiapine for alcoholism, by examining its effects on subjective intoxication and craving. METHOD: A total of 20 non-treatment-seeking alcohol-dependent individuals were randomized to one of the following conditions in a double-blind, placebo-controlled design: (1) quetiapine (400 mg/day); or (2) matched placebo. Participants were on the target medication dose (or matched placebo) for 4 weeks during which they completed weekly assessments of drinking, sleep, mood, and anxiety. Participants completed two counterbalanced intravenous placebo-alcohol administration sessions as well as cue-reactivity assessments. RESULTS: Analyses revealed a significant effect of quetiapine in reducing craving during the alcohol administration, the alcohol cue-exposure, and the weekly reports of alcohol craving. Quetiapine was also found to reduce subjective intoxication and alcohol-induced sedation during the alcohol administration paradigm. CONCLUSIONS: This study contributes critical new information about mechanisms of response to quetiapine for alcoholism, which, in turn, can inform larger-scale studies and ultimately, clinical practice. SN - 1432-2072 UR - https://www.unboundmedicine.com/medline/citation/21487653/A_human_laboratory_study_of_the_effects_of_quetiapine_on_subjective_intoxication_and_alcohol_craving_ L2 - https://dx.doi.org/10.1007/s00213-011-2287-3 DB - PRIME DP - Unbound Medicine ER -