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Association of bone microarchitecture with parathyroid hormone concentration and calcium intake in men: the STRAMBO study.
Eur J Endocrinol 2011; 165(1):151-9EJ

Abstract

OBJECTVIE: In the elderly, vitamin D deficit, low calcium intake, and impaired bone microarchitecture are associated with higher risk of hip fracture. We assessed the association of bone microarchitecture with calcium intake and serum concentrations of 25-hydroxycholecalciferol (25OHD) and parathyroid hormone (PTH) in men.

DESIGN

Cross-sectional analysis was performed in 1064 men aged 20-87 years not taking vitamin D or calcium supplements.

METHODS

Daily calcium intake was assessed using a food frequency questionnaire. Bone microarchitecture was assessed at distal radius and tibia by high-resolution peripheral quantitative computed tomography. We measured serum and urinary levels of biochemical bone turnover markers (BTMs). Statistical models were adjusted for age, weight, height, and glomerular filtration rate.

RESULTS

In 500 men aged <65 years, lower 25OHD levels and low calcium intake were associated with lower trabecular volumetric bone mineral density (Dtrab) at the distal tibia, due to lower trabecular number (Tb.N). Low calcium intake was associated with lower cortical thickness (Ct.Th). Higher PTH level was associated with higher BTM levels. In 563 men aged ≥65 years, the highest PTH quartile was associated with lower Ct.Th (tibia), lower Dtrab (both sites), and lower Tb.N (radius) compared with the lowest quartile. Low calcium intake was associated with lower Tb.N and more heterogenous trabecular distribution. BTM positively correlated with the PTH concentration.

CONCLUSION

In older men, elevated PTH concentration is associated with high bone turnover, poor trabecular microarchitecture (radius and tibia), and, at the distal tibia, lower Ct.Th. Low calcium intake is associated with lower Tb.N and more heterogenous trabecular distribution.

Authors+Show Affiliations

INSERM Research Unit 1033, Hôpital Edouard Herriot, Université de Lyon 1, Place d'Arsonval, 69437 Lyon, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21490123

Citation

Chaitou, A, et al. "Association of Bone Microarchitecture With Parathyroid Hormone Concentration and Calcium Intake in Men: the STRAMBO Study." European Journal of Endocrinology, vol. 165, no. 1, 2011, pp. 151-9.
Chaitou A, Boutroy S, Vilayphiou N, et al. Association of bone microarchitecture with parathyroid hormone concentration and calcium intake in men: the STRAMBO study. Eur J Endocrinol. 2011;165(1):151-9.
Chaitou, A., Boutroy, S., Vilayphiou, N., Varennes, A., Richard, M., Blaizot, S., ... Szulc, P. (2011). Association of bone microarchitecture with parathyroid hormone concentration and calcium intake in men: the STRAMBO study. European Journal of Endocrinology, 165(1), pp. 151-9. doi:10.1530/EJE-11-0184.
Chaitou A, et al. Association of Bone Microarchitecture With Parathyroid Hormone Concentration and Calcium Intake in Men: the STRAMBO Study. Eur J Endocrinol. 2011;165(1):151-9. PubMed PMID: 21490123.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of bone microarchitecture with parathyroid hormone concentration and calcium intake in men: the STRAMBO study. AU - Chaitou,A, AU - Boutroy,S, AU - Vilayphiou,N, AU - Varennes,A, AU - Richard,M, AU - Blaizot,S, AU - Munoz,F, AU - Delmas,P D, AU - Goudable,J, AU - Chapurlat,R, AU - Szulc,P, Y1 - 2011/04/13/ PY - 2011/4/15/entrez PY - 2011/4/15/pubmed PY - 2011/8/23/medline SP - 151 EP - 9 JF - European journal of endocrinology JO - Eur. J. Endocrinol. VL - 165 IS - 1 N2 - UNLABELLED: OBJECTVIE: In the elderly, vitamin D deficit, low calcium intake, and impaired bone microarchitecture are associated with higher risk of hip fracture. We assessed the association of bone microarchitecture with calcium intake and serum concentrations of 25-hydroxycholecalciferol (25OHD) and parathyroid hormone (PTH) in men. DESIGN: Cross-sectional analysis was performed in 1064 men aged 20-87 years not taking vitamin D or calcium supplements. METHODS: Daily calcium intake was assessed using a food frequency questionnaire. Bone microarchitecture was assessed at distal radius and tibia by high-resolution peripheral quantitative computed tomography. We measured serum and urinary levels of biochemical bone turnover markers (BTMs). Statistical models were adjusted for age, weight, height, and glomerular filtration rate. RESULTS: In 500 men aged <65 years, lower 25OHD levels and low calcium intake were associated with lower trabecular volumetric bone mineral density (Dtrab) at the distal tibia, due to lower trabecular number (Tb.N). Low calcium intake was associated with lower cortical thickness (Ct.Th). Higher PTH level was associated with higher BTM levels. In 563 men aged ≥65 years, the highest PTH quartile was associated with lower Ct.Th (tibia), lower Dtrab (both sites), and lower Tb.N (radius) compared with the lowest quartile. Low calcium intake was associated with lower Tb.N and more heterogenous trabecular distribution. BTM positively correlated with the PTH concentration. CONCLUSION: In older men, elevated PTH concentration is associated with high bone turnover, poor trabecular microarchitecture (radius and tibia), and, at the distal tibia, lower Ct.Th. Low calcium intake is associated with lower Tb.N and more heterogenous trabecular distribution. SN - 1479-683X UR - https://www.unboundmedicine.com/medline/citation/21490123/Association_of_bone_microarchitecture_with_parathyroid_hormone_concentration_and_calcium_intake_in_men:_the_STRAMBO_study_ L2 - https://eje.bioscientifica.com/doi/10.1530/EJE-11-0184 DB - PRIME DP - Unbound Medicine ER -