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Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption.
PLoS Genet. 2011 Apr; 7(4):e1002033.PG

Abstract

We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2.

Authors+Show Affiliations

Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, United States of America.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Meta-Analysis
Research Support, N.I.H., Extramural
Research Support, N.I.H., Intramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21490707

Citation

Cornelis, Marilyn C., et al. "Genome-wide Meta-analysis Identifies Regions On 7p21 (AHR) and 15q24 (CYP1A2) as Determinants of Habitual Caffeine Consumption." PLoS Genetics, vol. 7, no. 4, 2011, pp. e1002033.
Cornelis MC, Monda KL, Yu K, et al. Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genet. 2011;7(4):e1002033.
Cornelis, M. C., Monda, K. L., Yu, K., Paynter, N., Azzato, E. M., Bennett, S. N., Berndt, S. I., Boerwinkle, E., Chanock, S., Chatterjee, N., Couper, D., Curhan, G., Heiss, G., Hu, F. B., Hunter, D. J., Jacobs, K., Jensen, M. K., Kraft, P., Landi, M. T., ... Caporaso, N. E. (2011). Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. PLoS Genetics, 7(4), e1002033. https://doi.org/10.1371/journal.pgen.1002033
Cornelis MC, et al. Genome-wide Meta-analysis Identifies Regions On 7p21 (AHR) and 15q24 (CYP1A2) as Determinants of Habitual Caffeine Consumption. PLoS Genet. 2011;7(4):e1002033. PubMed PMID: 21490707.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Genome-wide meta-analysis identifies regions on 7p21 (AHR) and 15q24 (CYP1A2) as determinants of habitual caffeine consumption. AU - Cornelis,Marilyn C, AU - Monda,Keri L, AU - Yu,Kai, AU - Paynter,Nina, AU - Azzato,Elizabeth M, AU - Bennett,Siiri N, AU - Berndt,Sonja I, AU - Boerwinkle,Eric, AU - Chanock,Stephen, AU - Chatterjee,Nilanjan, AU - Couper,David, AU - Curhan,Gary, AU - Heiss,Gerardo, AU - Hu,Frank B, AU - Hunter,David J, AU - Jacobs,Kevin, AU - Jensen,Majken K, AU - Kraft,Peter, AU - Landi,Maria Teresa, AU - Nettleton,Jennifer A, AU - Purdue,Mark P, AU - Rajaraman,Preetha, AU - Rimm,Eric B, AU - Rose,Lynda M, AU - Rothman,Nathaniel, AU - Silverman,Debra, AU - Stolzenberg-Solomon,Rachael, AU - Subar,Amy, AU - Yeager,Meredith, AU - Chasman,Daniel I, AU - van Dam,Rob M, AU - Caporaso,Neil E, Y1 - 2011/04/07/ PY - 2010/11/17/received PY - 2011/02/06/accepted PY - 2011/4/15/entrez PY - 2011/4/15/pubmed PY - 2011/8/19/medline SP - e1002033 EP - e1002033 JF - PLoS genetics JO - PLoS Genet. VL - 7 IS - 4 N2 - We report the first genome-wide association study of habitual caffeine intake. We included 47,341 individuals of European descent based on five population-based studies within the United States. In a meta-analysis adjusted for age, sex, smoking, and eigenvectors of population variation, two loci achieved genome-wide significance: 7p21 (P = 2.4 × 10(-19)), near AHR, and 15q24 (P = 5.2 × 10(-14)), between CYP1A1 and CYP1A2. Both the AHR and CYP1A2 genes are biologically plausible candidates as CYP1A2 metabolizes caffeine and AHR regulates CYP1A2. SN - 1553-7404 UR - https://www.unboundmedicine.com/medline/citation/21490707/Genome_wide_meta_analysis_identifies_regions_on_7p21__AHR__and_15q24__CYP1A2__as_determinants_of_habitual_caffeine_consumption_ L2 - http://dx.plos.org/10.1371/journal.pgen.1002033 DB - PRIME DP - Unbound Medicine ER -