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[Calciphylaxis. A call for interdisciplinary cooperation].
Hautarzt 2011; 62(6):452-8H

Abstract

Calciphylaxis is a rare, often very painful and potentially life-threatening disorder at the interface between nephrology and dermatology. It is characterized by skin lesions and ulcerations following calcification and occlusion of cutaneous arterioles. Most patients have chronic kidney disease or are on dialysis. A concert of various, still incompletely understood local and systemic risk factors is necessary to cause the development of calciphylaxis. Since randomized prospective trials are missing, interdisciplinary treatment is based on pathophysiological considerations as well as evidence derived from case reports or case series. Normalization of mineral metabolism, intensifying dialysis and avoidance of coumarins, as well as administration of calcimimetics, bisphosphonates and sodium thiosulfate and hyperbaric oxygen therapy are often used. Supportive measures include analgesics, antibiotics and local wound care. We have initiated an internet-based registry for patients with calciphylaxis in order to collect data for improved patient care (with support from Amgen) (www.calciphylaxie.de).

Authors+Show Affiliations

Medizinische Klinik I, Kardiologie, Universitätsklinikum der RWTH Aachen. Vincent.Brandenburg@post.rwth-aachen.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

ger

PubMed ID

21491129

Citation

Brandenburg, V M., et al. "[Calciphylaxis. a Call for Interdisciplinary Cooperation]." Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, vol. 62, no. 6, 2011, pp. 452-8.
Brandenburg VM, Schmitz S, Floege J, et al. [Calciphylaxis. A call for interdisciplinary cooperation]. Hautarzt. 2011;62(6):452-8.
Brandenburg, V. M., Schmitz, S., Floege, J., Amann, K., & Ketteler, M. (2011). [Calciphylaxis. A call for interdisciplinary cooperation]. Der Hautarzt; Zeitschrift Fur Dermatologie, Venerologie, Und Verwandte Gebiete, 62(6), pp. 452-8. doi:10.1007/s00105-011-2169-y.
Brandenburg VM, et al. [Calciphylaxis. a Call for Interdisciplinary Cooperation]. Hautarzt. 2011;62(6):452-8. PubMed PMID: 21491129.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Calciphylaxis. A call for interdisciplinary cooperation]. AU - Brandenburg,V M, AU - Schmitz,S, AU - Floege,J, AU - Amann,K, AU - Ketteler,M, PY - 2011/4/15/entrez PY - 2011/4/15/pubmed PY - 2012/3/16/medline SP - 452 EP - 8 JF - Der Hautarzt; Zeitschrift fur Dermatologie, Venerologie, und verwandte Gebiete JO - Hautarzt VL - 62 IS - 6 N2 - Calciphylaxis is a rare, often very painful and potentially life-threatening disorder at the interface between nephrology and dermatology. It is characterized by skin lesions and ulcerations following calcification and occlusion of cutaneous arterioles. Most patients have chronic kidney disease or are on dialysis. A concert of various, still incompletely understood local and systemic risk factors is necessary to cause the development of calciphylaxis. Since randomized prospective trials are missing, interdisciplinary treatment is based on pathophysiological considerations as well as evidence derived from case reports or case series. Normalization of mineral metabolism, intensifying dialysis and avoidance of coumarins, as well as administration of calcimimetics, bisphosphonates and sodium thiosulfate and hyperbaric oxygen therapy are often used. Supportive measures include analgesics, antibiotics and local wound care. We have initiated an internet-based registry for patients with calciphylaxis in order to collect data for improved patient care (with support from Amgen) (www.calciphylaxie.de). SN - 1432-1173 UR - https://www.unboundmedicine.com/medline/citation/21491129/[Calciphylaxis__A_call_for_interdisciplinary_cooperation]_ L2 - https://dx.doi.org/10.1007/s00105-011-2169-y DB - PRIME DP - Unbound Medicine ER -