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T1-weighted MRI shows stage-dependent substantia nigra signal loss in Parkinson's disease.
Mov Disord. 2011 Aug 01; 26(9):1633-8.MD

Abstract

Depigmentation of the substantia nigra is a conspicuous pathological feature of Parkinson's disease and related to a loss of neuromelanin. Similar to melanin, neuromelanin has paramagnetic properties resulting in signal increase on specific T1-weighted magnetic resonance imaging. The aim of this study was to assess signal changes in the substantia nigra in patients with Parkinson's disease using an optimized neuromelanin-sensitive T1 scan. Ten patients with Parkinson's disease and 12 matched controls underwent high-resolution T1-weighted magnetic resonance imaging with magnetization transfer effect at 3T. The size and signal intensity of the substantia nigra pars compacta were determined as the number of pixels with signal intensity higher than background signal intensity+3 standard deviations and regional contrast ratio. Patients were subclassified as early stage (n=6) and late stage (n=4) using the Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr Parkinson's disease staging scale. The T1 hyperintense area in the substantia nigra was substantially smaller in patients compared with controls (-60%, P<.01), and contrast was reduced (-3%, P<.05). Size reduction was even more pronounced in more advanced disease (-78%) than in early-stage disease (-47%). We present preliminary findings using a modified T1-weighted magnetic resonance imaging technique showing stage-dependent substantia nigra signal reduction in Parkinson's disease as a putative marker of neuromelanin loss. Our data suggest that reduction in the size of neuromelanin-rich substantia nigra correlates well with postmortem observations of dopaminergic neuron loss. Further validation of our results could potentially lead to development of a new biomarker of disease progression in Parkinson's disease.

Authors+Show Affiliations

Radiological & Imaging Sciences, University of Nottingham, and Department of Medical Physics, Queen's Medical Centre, University Hospitals of Nottingham, Nottingham, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21491489

Citation

Schwarz, Stefan T., et al. "T1-weighted MRI Shows Stage-dependent Substantia Nigra Signal Loss in Parkinson's Disease." Movement Disorders : Official Journal of the Movement Disorder Society, vol. 26, no. 9, 2011, pp. 1633-8.
Schwarz ST, Rittman T, Gontu V, et al. T1-weighted MRI shows stage-dependent substantia nigra signal loss in Parkinson's disease. Mov Disord. 2011;26(9):1633-8.
Schwarz, S. T., Rittman, T., Gontu, V., Morgan, P. S., Bajaj, N., & Auer, D. P. (2011). T1-weighted MRI shows stage-dependent substantia nigra signal loss in Parkinson's disease. Movement Disorders : Official Journal of the Movement Disorder Society, 26(9), 1633-8. https://doi.org/10.1002/mds.23722
Schwarz ST, et al. T1-weighted MRI Shows Stage-dependent Substantia Nigra Signal Loss in Parkinson's Disease. Mov Disord. 2011 Aug 1;26(9):1633-8. PubMed PMID: 21491489.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - T1-weighted MRI shows stage-dependent substantia nigra signal loss in Parkinson's disease. AU - Schwarz,Stefan T, AU - Rittman,Timothy, AU - Gontu,Vamsi, AU - Morgan,Paul S, AU - Bajaj,Nin, AU - Auer,Dorothee P, Y1 - 2011/04/12/ PY - 2010/07/20/received PY - 2011/02/11/revised PY - 2011/02/24/accepted PY - 2011/4/15/entrez PY - 2011/4/15/pubmed PY - 2011/12/13/medline SP - 1633 EP - 8 JF - Movement disorders : official journal of the Movement Disorder Society JO - Mov Disord VL - 26 IS - 9 N2 - Depigmentation of the substantia nigra is a conspicuous pathological feature of Parkinson's disease and related to a loss of neuromelanin. Similar to melanin, neuromelanin has paramagnetic properties resulting in signal increase on specific T1-weighted magnetic resonance imaging. The aim of this study was to assess signal changes in the substantia nigra in patients with Parkinson's disease using an optimized neuromelanin-sensitive T1 scan. Ten patients with Parkinson's disease and 12 matched controls underwent high-resolution T1-weighted magnetic resonance imaging with magnetization transfer effect at 3T. The size and signal intensity of the substantia nigra pars compacta were determined as the number of pixels with signal intensity higher than background signal intensity+3 standard deviations and regional contrast ratio. Patients were subclassified as early stage (n=6) and late stage (n=4) using the Unified Parkinson's Disease Rating Scale and the Hoehn and Yahr Parkinson's disease staging scale. The T1 hyperintense area in the substantia nigra was substantially smaller in patients compared with controls (-60%, P<.01), and contrast was reduced (-3%, P<.05). Size reduction was even more pronounced in more advanced disease (-78%) than in early-stage disease (-47%). We present preliminary findings using a modified T1-weighted magnetic resonance imaging technique showing stage-dependent substantia nigra signal reduction in Parkinson's disease as a putative marker of neuromelanin loss. Our data suggest that reduction in the size of neuromelanin-rich substantia nigra correlates well with postmortem observations of dopaminergic neuron loss. Further validation of our results could potentially lead to development of a new biomarker of disease progression in Parkinson's disease. SN - 1531-8257 UR - https://www.unboundmedicine.com/medline/citation/21491489/T1_weighted_MRI_shows_stage_dependent_substantia_nigra_signal_loss_in_Parkinson's_disease_ L2 - https://doi.org/10.1002/mds.23722 DB - PRIME DP - Unbound Medicine ER -