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Measurement of plasma ox-LDL and carotid IMT may represent useful markers for atherosclerosis and may represent potential targets for therapeutic interventions.
Rev Med Chir Soc Med Nat Iasi 2009 Apr-Jun; 113(2):397-401RM

Abstract

Oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Increased wall thickness precedes plaque formation and noninvasive B-mode ultrasonographic measurement of IMT is considered a useful marker of the development of the carotid atherosclerosis.

MATERIAL AND METHOD

The present study was designed to assess the association of oxidized low-density lipoprotein (ox-LDL) with carotid intima-media thickness (IMT) in hypertensive patients. Oxidized LDL (enzyme-linked immunosorbent assay, Elisa) and carotid IMT (high-resolution B-mode ultrasonography) were assessed in 74 patients, aged between 45 and 65 years, diagnosticated with arterial hypertension.

RESULTS

We observed significantly higher plasma levels of total cholesterol (236.32 +/- 41.96 mg/dl), LDL cholesterol (166.92 +/- 38.55 mg/dl), triglycerides (180.79 +/- 72.05 mg/dl) and low plasma levels of HDL-cholesterol (33.24 +/- 7.99 mg/dl) in all patients. We noticed higher plasma levels of ox-LDL (77.34 +/- 24.78 mg/dl) and carotid IMT was increased (1.41 +/- 0.31 mm). The statistically analysis done using Pearson's test and Student's t - test indicated that there were correlations of ox-LDL with: IMT (p < 0.05, r = 0.408), total cholesterol (p < 0.05, r = 0.498), LDL-cholesterol (p < 0.05, r = 0.527), triglycerides (p < 0.05, r = 0.385) and HDL-cholesterol (p < 0.05, r = -0.442).

CONCLUSION

Higher plasma levels of ox-LDL were associated with increased carotid IMT in hypertensive patients. Measurement of plasma Ox-LDL and carotid IMT may represent useful markers for atherosclerosis and may represent potential targets for therapeutic interventions.

Authors+Show Affiliations

Anatomy, Physiology and Pathophysiology Department, School of Pharmacy, University of Medicine and Pharmacy V. Babeş Timişoara.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21491821

Citation

Savoiu, Germaine, et al. "Measurement of Plasma ox-LDL and Carotid IMT May Represent Useful Markers for Atherosclerosis and May Represent Potential Targets for Therapeutic Interventions." Revista Medico-chirurgicala a Societatii De Medici Si Naturalisti Din Iasi, vol. 113, no. 2, 2009, pp. 397-401.
Savoiu G, Drăgan S, Cristescu C, et al. Measurement of plasma ox-LDL and carotid IMT may represent useful markers for atherosclerosis and may represent potential targets for therapeutic interventions. Rev Med Chir Soc Med Nat Iasi. 2009;113(2):397-401.
Savoiu, G., Drăgan, S., Cristescu, C., Serban, C., Noveanus, L., Ionescu, D., ... Voicu, M. (2009). Measurement of plasma ox-LDL and carotid IMT may represent useful markers for atherosclerosis and may represent potential targets for therapeutic interventions. Revista Medico-chirurgicala a Societatii De Medici Si Naturalisti Din Iasi, 113(2), pp. 397-401.
Savoiu G, et al. Measurement of Plasma ox-LDL and Carotid IMT May Represent Useful Markers for Atherosclerosis and May Represent Potential Targets for Therapeutic Interventions. Rev Med Chir Soc Med Nat Iasi. 2009;113(2):397-401. PubMed PMID: 21491821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Measurement of plasma ox-LDL and carotid IMT may represent useful markers for atherosclerosis and may represent potential targets for therapeutic interventions. AU - Savoiu,Germaine, AU - Drăgan,Simona, AU - Cristescu,Carmen, AU - Serban,Corina, AU - Noveanus,Lavinia, AU - Ionescu,Daniela, AU - Nicola,T, AU - Duicu,Oana, AU - Raducan,Andreea, AU - Voicu,Mirela, PY - 2011/4/16/entrez PY - 2009/4/1/pubmed PY - 2011/6/28/medline SP - 397 EP - 401 JF - Revista medico-chirurgicala a Societatii de Medici si Naturalisti din Iasi JO - Rev Med Chir Soc Med Nat Iasi VL - 113 IS - 2 N2 - UNLABELLED: Oxidation of LDL plays an important role in the pathogenesis of atherosclerosis. Increased wall thickness precedes plaque formation and noninvasive B-mode ultrasonographic measurement of IMT is considered a useful marker of the development of the carotid atherosclerosis. MATERIAL AND METHOD: The present study was designed to assess the association of oxidized low-density lipoprotein (ox-LDL) with carotid intima-media thickness (IMT) in hypertensive patients. Oxidized LDL (enzyme-linked immunosorbent assay, Elisa) and carotid IMT (high-resolution B-mode ultrasonography) were assessed in 74 patients, aged between 45 and 65 years, diagnosticated with arterial hypertension. RESULTS: We observed significantly higher plasma levels of total cholesterol (236.32 +/- 41.96 mg/dl), LDL cholesterol (166.92 +/- 38.55 mg/dl), triglycerides (180.79 +/- 72.05 mg/dl) and low plasma levels of HDL-cholesterol (33.24 +/- 7.99 mg/dl) in all patients. We noticed higher plasma levels of ox-LDL (77.34 +/- 24.78 mg/dl) and carotid IMT was increased (1.41 +/- 0.31 mm). The statistically analysis done using Pearson's test and Student's t - test indicated that there were correlations of ox-LDL with: IMT (p < 0.05, r = 0.408), total cholesterol (p < 0.05, r = 0.498), LDL-cholesterol (p < 0.05, r = 0.527), triglycerides (p < 0.05, r = 0.385) and HDL-cholesterol (p < 0.05, r = -0.442). CONCLUSION: Higher plasma levels of ox-LDL were associated with increased carotid IMT in hypertensive patients. Measurement of plasma Ox-LDL and carotid IMT may represent useful markers for atherosclerosis and may represent potential targets for therapeutic interventions. SN - 0048-7848 UR - https://www.unboundmedicine.com/medline/citation/21491821/Measurement_of_plasma_ox_LDL_and_carotid_IMT_may_represent_useful_markers_for_atherosclerosis_and_may_represent_potential_targets_for_therapeutic_interventions_ L2 - https://medlineplus.gov/highbloodpressure.html DB - PRIME DP - Unbound Medicine ER -