Citation
Liu, Wei, et al. "LYG-202 Inhibits the Proliferation of Human Colorectal Carcinoma HCT-116 Cells Through Induction of G1/S Cell Cycle Arrest and Apoptosis Via P53 and p21(WAF1/Cip1) Expression." Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire, vol. 89, no. 3, 2011, pp. 287-98.
Liu W, Dai Q, Lu N, et al. LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression. Biochem Cell Biol. 2011;89(3):287-98.
Liu, W., Dai, Q., Lu, N., Wei, L., Ha, J., Rong, J., Mu, R., You, Q., Li, Z., & Guo, Q. (2011). LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression. Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire, 89(3), 287-98. https://doi.org/10.1139/O10-162
Liu W, et al. LYG-202 Inhibits the Proliferation of Human Colorectal Carcinoma HCT-116 Cells Through Induction of G1/S Cell Cycle Arrest and Apoptosis Via P53 and p21(WAF1/Cip1) Expression. Biochem Cell Biol. 2011;89(3):287-98. PubMed PMID: 21491996.
TY - JOUR
T1 - LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression.
AU - Liu,Wei,
AU - Dai,Qinsheng,
AU - Lu,Na,
AU - Wei,Libin,
AU - Ha,Jun,
AU - Rong,Jingjing,
AU - Mu,Rong,
AU - You,Qidong,
AU - Li,Zhiyu,
AU - Guo,Qinglong,
Y1 - 2011/04/14/
PY - 2011/4/16/entrez
PY - 2011/4/16/pubmed
PY - 2011/12/15/medline
SP - 287
EP - 98
JF - Biochemistry and cell biology = Biochimie et biologie cellulaire
JO - Biochem Cell Biol
VL - 89
IS - 3
N2 - We recently established that LYG-202, a new flavonoid with a piperazine substitution, exerts an anti-tumor effect in vivo and in vitro. In the present study, we demonstrate that LYG-202 induces G1/S phase arrest and apoptosis in human colorectal carcinoma HCT-116 cells. Data showed that the blockade of the cell cycle was associated with increased p21(WAF1/Cip1) and Rb levels and reduced expression of cyclin D1, cyclin E, and CDK4. Moreover, PARP cleavage, activation of caspase-3, caspase-8, and caspase-9, and an increased ratio of Bax/Bcl-2 were detected in LYG-202-induced apoptosis. Additionally, activation of p53 resulted in the up-regulation of its downstream targets PUMA and p21(WAF1/Cip1), as well as the down-regulation of its negative regulator MDM2, suggesting that the p53 pathway may play a crucial role in LYG-202-induced cell cycle arrest and apoptosis. Furthermore, siRNA knockdown of p53 attenuated the G1 cell cycle arrest and apoptosis induced by LYG-202, as the effects of LYG-202 on up-regulation of p21(WAF1/Cip1) and down-regulation of Bcl-2 and pro-caspase-3 were partly inhibited in p53 siRNA transfected cells compared with control siRNA transfected cells. Collectively, these data indicate that LYG-202 exerts its anti-tumor potency by activating the p53-p21 pathway for G1/S cell cycle arrest and apoptosis in colorectal cancer cells.
SN - 1208-6002
UR - https://www.unboundmedicine.com/medline/citation/21491996/LYG_202_inhibits_the_proliferation_of_human_colorectal_carcinoma_HCT_116_cells_through_induction_of_G1/S_cell_cycle_arrest_and_apoptosis_via_p53_and_p21_WAF1/Cip1__expression_
L2 - https://cdnsciencepub.com/doi/10.1139/o10-162?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed
DB - PRIME
DP - Unbound Medicine
ER -
