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Biofilms in chronic rhinosinusitis with nasal polyps.
Otolaryngol Head Neck Surg. 2011 Apr; 144(4):612-6.OH

Abstract

OBJECTIVE

(1) Evaluate the presence of biofilms in patients with chronic sinusitis with nasal polyps (CRSwNP) and (2) investigate the association of biofilm presence and CRSwNP.

STUDY DESIGN

Cross-sectional study.

SETTING

University-based tertiary care center.

SUBJECTS AND METHODS

The study group consisted of 33 consecutive patients undergoing functional endoscopic sinus surgery for CRSwNP. The control group consisted of 27 control patients undergoing septoplasty for nasal obstruction without diagnosis of chronic sinusitis. Mucosal samples were harvested intraoperatively for scanning electron microscopic examination to determine biofilm presence. Statistical analysis was performed. For all statistical tests, P = .05 was considered significant.

RESULTS

Biofilms were found in 24 (72.7%) of the 33 patients with CRSwNP and in 13 (48.1%) of the 27 septoplasty patients (odds ratio = 2.87; 95% confidence interval, 0.98-8.42; P = .051).

CONCLUSION

(1) Biofilms were present in patients undergoing functional endoscopic sinus surgery for CRSwNP and also in controls without chronic sinusitis. This suggests that biofilms may not be sufficient to cause chronic sinusitis without other cofactors. Host factors could be the responsible for the pathogenesis of biofilms. (2) Although the prevalence of biofilms in patients with CRSwNP was not significantly different from that in the controls, the extremely wide 95% confidence interval, which is just below unity, suggests that a meaningful clinical difference may have been missed because of low statistical power. Further studies are necessary.

Authors+Show Affiliations

Department of Otorhinolaryngology and Ophthalmology, School of Medicine, University of São Paulo, São Paulo, SP, Brazil. bezerratfp@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21493244

Citation

Bezerra, Thiago Freire Pinto, et al. "Biofilms in Chronic Rhinosinusitis With Nasal Polyps." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 144, no. 4, 2011, pp. 612-6.
Bezerra TF, Padua FG, Gebrim EM, et al. Biofilms in chronic rhinosinusitis with nasal polyps. Otolaryngol Head Neck Surg. 2011;144(4):612-6.
Bezerra, T. F., Padua, F. G., Gebrim, E. M., Saldiva, P. H., & Voegels, R. L. (2011). Biofilms in chronic rhinosinusitis with nasal polyps. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 144(4), 612-6. https://doi.org/10.1177/0194599811399536
Bezerra TF, et al. Biofilms in Chronic Rhinosinusitis With Nasal Polyps. Otolaryngol Head Neck Surg. 2011;144(4):612-6. PubMed PMID: 21493244.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Biofilms in chronic rhinosinusitis with nasal polyps. AU - Bezerra,Thiago Freire Pinto, AU - Padua,Francini Grecco de Melo, AU - Gebrim,Eloisa Maria Mello Santiago, AU - Saldiva,Paulo Hilário Nascimento, AU - Voegels,Richard Louis, Y1 - 2011/02/24/ PY - 2011/4/16/entrez PY - 2011/4/16/pubmed PY - 2011/6/22/medline SP - 612 EP - 6 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 144 IS - 4 N2 - OBJECTIVE: (1) Evaluate the presence of biofilms in patients with chronic sinusitis with nasal polyps (CRSwNP) and (2) investigate the association of biofilm presence and CRSwNP. STUDY DESIGN: Cross-sectional study. SETTING: University-based tertiary care center. SUBJECTS AND METHODS: The study group consisted of 33 consecutive patients undergoing functional endoscopic sinus surgery for CRSwNP. The control group consisted of 27 control patients undergoing septoplasty for nasal obstruction without diagnosis of chronic sinusitis. Mucosal samples were harvested intraoperatively for scanning electron microscopic examination to determine biofilm presence. Statistical analysis was performed. For all statistical tests, P = .05 was considered significant. RESULTS: Biofilms were found in 24 (72.7%) of the 33 patients with CRSwNP and in 13 (48.1%) of the 27 septoplasty patients (odds ratio = 2.87; 95% confidence interval, 0.98-8.42; P = .051). CONCLUSION: (1) Biofilms were present in patients undergoing functional endoscopic sinus surgery for CRSwNP and also in controls without chronic sinusitis. This suggests that biofilms may not be sufficient to cause chronic sinusitis without other cofactors. Host factors could be the responsible for the pathogenesis of biofilms. (2) Although the prevalence of biofilms in patients with CRSwNP was not significantly different from that in the controls, the extremely wide 95% confidence interval, which is just below unity, suggests that a meaningful clinical difference may have been missed because of low statistical power. Further studies are necessary. SN - 1097-6817 UR - https://www.unboundmedicine.com/medline/citation/21493244/Biofilms_in_chronic_rhinosinusitis_with_nasal_polyps_ L2 - http://journals.sagepub.com/doi/full/10.1177/0194599811399536?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -