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Triazole and dihydroimidazole alkaloids from the marine sediment-derived fungus Penicillium paneum SD-44.
J Nat Prod. 2011 May 27; 74(5):1331-4.JN

Abstract

A novel triazole carboxylic acid, penipanoid A (1), two new quinazolinone alkaloids, penipanoids B (2) and C (3), and a very recently reported quinazolinone derivative (4) were isolated from the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated by spectroscopic analysis, and the structure for 1 was confirmed by X-ray crystallographic analysis. Compound 1 represents the first example of a triazole derivative from marine sediment-derived fungi, and compound 2 is a rare quinazolinone derivative having a dihydroimidazole ring system. The cytotoxicity of compounds 1 and 4 and the antimicrobial activity of 1-4 were evaluated.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Li CS
Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, People's Republic of China.
An CY
No affiliation info available
Li XM
No affiliation info available
Gao SS
No affiliation info available
Cui CM
No affiliation info available
Sun HF
No affiliation info available
Wang BG
No affiliation info available

MeSH

AlkaloidsAntineoplastic AgentsCarboxylic AcidsDrug Screening Assays, AntitumorGeologic SedimentsHumansImidazolesMicrobial Sensitivity TestsMolecular StructurePenicilliumQuinazolinonesTriazoles

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21495659

Citation

Li, Chun-Shun, et al. "Triazole and Dihydroimidazole Alkaloids From the Marine Sediment-derived Fungus Penicillium Paneum SD-44." Journal of Natural Products, vol. 74, no. 5, 2011, pp. 1331-4.
Li CS, An CY, Li XM, et al. Triazole and dihydroimidazole alkaloids from the marine sediment-derived fungus Penicillium paneum SD-44. J Nat Prod. 2011;74(5):1331-4.
Li, C. S., An, C. Y., Li, X. M., Gao, S. S., Cui, C. M., Sun, H. F., & Wang, B. G. (2011). Triazole and dihydroimidazole alkaloids from the marine sediment-derived fungus Penicillium paneum SD-44. Journal of Natural Products, 74(5), 1331-4. https://doi.org/10.1021/np200037z
Li CS, et al. Triazole and Dihydroimidazole Alkaloids From the Marine Sediment-derived Fungus Penicillium Paneum SD-44. J Nat Prod. 2011 May 27;74(5):1331-4. PubMed PMID: 21495659.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Triazole and dihydroimidazole alkaloids from the marine sediment-derived fungus Penicillium paneum SD-44. AU - Li,Chun-Shun, AU - An,Chun-Yan, AU - Li,Xiao-Ming, AU - Gao,Shu-Shan, AU - Cui,Chuan-Ming, AU - Sun,Hao-Fen, AU - Wang,Bin-Gui, Y1 - 2011/04/15/ PY - 2011/4/19/entrez PY - 2011/4/19/pubmed PY - 2011/8/19/medline SP - 1331 EP - 4 JF - Journal of natural products JO - J Nat Prod VL - 74 IS - 5 N2 - A novel triazole carboxylic acid, penipanoid A (1), two new quinazolinone alkaloids, penipanoids B (2) and C (3), and a very recently reported quinazolinone derivative (4) were isolated from the marine sediment-derived fungus Penicillium paneum SD-44. Their structures were elucidated by spectroscopic analysis, and the structure for 1 was confirmed by X-ray crystallographic analysis. Compound 1 represents the first example of a triazole derivative from marine sediment-derived fungi, and compound 2 is a rare quinazolinone derivative having a dihydroimidazole ring system. The cytotoxicity of compounds 1 and 4 and the antimicrobial activity of 1-4 were evaluated. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/21495659/Triazole_and_dihydroimidazole_alkaloids_from_the_marine_sediment_derived_fungus_Penicillium_paneum_SD_44_ L2 - https://doi.org/10.1021/np200037z DB - PRIME DP - Unbound Medicine ER -