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Interaction between tumour necrosis factor-α gene polymorphisms and substance use on risk of betel quid-related oral and pharyngeal squamous cell carcinoma in Taiwan.
Arch Oral Biol. 2011 Oct; 56(10):1162-9.AO

Abstract

OBJECTIVE

Betel quid (BQ) components induce the secretion of tumour necrosis factor-alpha (TNF-α) in oral keratinocytes, which promotes oral mucosal inflammation and oral cancer. This study was carried out to evaluate the association of TNFA genetic variants (-308G>A and -238G>A) with the risk and prognosis of BQ-related oral and pharyngeal squamous cell carcinoma (OPSCC).

DESIGN

A total of 403 subjects (205 cancer cases and 198 healthy controls) who habitually chewed BQ were recruited. The genotypes were determined by TaqMan real-time assays.

RESULTS

G allele and G/G genotype at TNFA -308 were associated with a 1.95-fold (95%CI: 1.16-3.28, p(corrected)=0.024) and 2.28-fold (95%CI: 1.30-4.00, p(corrected)=0.008) increased risk of cancer as compared to those with A allele or A/A+A/G genotypes, respectively. In addition, G allele (p=0.080) and G/G genotype (p=0.076) at TNFA -238 were associated with a borderline but statistically significant increased risk of OPSCC. The combined G/G+G/G genotype at both loci had a 2.37-fold increased risk of OPSCC as compared to those with other combined genotypes (95%CI: 1.41-4.00, p=0.001). Interactions between combined genotypes and smoking status were also found to contribute to risk of BQ-related OPSCC. There was no association of TNFA genotypes with clinicopathologic findings or the survival of OPSCC patients.

CONCLUSIONS

BQ-chewers who carry the G allele or G/G genotype in TNFA -308 may have an increased risk of OPSCC. The intensity of cigarette smoking modulates the effect of the combined TNFA genotypes on risk of BQ-related OPSCC.

Authors+Show Affiliations

Department of Dentistry, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21497332

Citation

Yang, Cheng-Mei, et al. "Interaction Between Tumour Necrosis Factor-α Gene Polymorphisms and Substance Use On Risk of Betel Quid-related Oral and Pharyngeal Squamous Cell Carcinoma in Taiwan." Archives of Oral Biology, vol. 56, no. 10, 2011, pp. 1162-9.
Yang CM, Hou YY, Chiu YT, et al. Interaction between tumour necrosis factor-α gene polymorphisms and substance use on risk of betel quid-related oral and pharyngeal squamous cell carcinoma in Taiwan. Arch Oral Biol. 2011;56(10):1162-9.
Yang, C. M., Hou, Y. Y., Chiu, Y. T., Chen, H. C., Chu, S. T., Chi, C. C., Hsiao, M., Lee, C. Y., Hsieh, C. J., Lin, Y. C., Hsieh, Y. D., & Ger, L. P. (2011). Interaction between tumour necrosis factor-α gene polymorphisms and substance use on risk of betel quid-related oral and pharyngeal squamous cell carcinoma in Taiwan. Archives of Oral Biology, 56(10), 1162-9. https://doi.org/10.1016/j.archoralbio.2011.03.009
Yang CM, et al. Interaction Between Tumour Necrosis Factor-α Gene Polymorphisms and Substance Use On Risk of Betel Quid-related Oral and Pharyngeal Squamous Cell Carcinoma in Taiwan. Arch Oral Biol. 2011;56(10):1162-9. PubMed PMID: 21497332.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Interaction between tumour necrosis factor-α gene polymorphisms and substance use on risk of betel quid-related oral and pharyngeal squamous cell carcinoma in Taiwan. AU - Yang,Cheng-Mei, AU - Hou,Yu-Yi, AU - Chiu,Yi-Ten, AU - Chen,Hung-Chih, AU - Chu,Sau-Tung, AU - Chi,Chao-Chuan, AU - Hsiao,Michael, AU - Lee,Chien-Yiing, AU - Hsieh,Christina Jen-Chia, AU - Lin,Yu-Chen, AU - Hsieh,Yao-Dung, AU - Ger,Luo-Ping, Y1 - 2011/04/16/ PY - 2010/12/08/received PY - 2011/01/31/revised PY - 2011/03/18/accepted PY - 2011/4/19/entrez PY - 2011/4/19/pubmed PY - 2012/3/1/medline SP - 1162 EP - 9 JF - Archives of oral biology JO - Arch Oral Biol VL - 56 IS - 10 N2 - OBJECTIVE: Betel quid (BQ) components induce the secretion of tumour necrosis factor-alpha (TNF-α) in oral keratinocytes, which promotes oral mucosal inflammation and oral cancer. This study was carried out to evaluate the association of TNFA genetic variants (-308G>A and -238G>A) with the risk and prognosis of BQ-related oral and pharyngeal squamous cell carcinoma (OPSCC). DESIGN: A total of 403 subjects (205 cancer cases and 198 healthy controls) who habitually chewed BQ were recruited. The genotypes were determined by TaqMan real-time assays. RESULTS: G allele and G/G genotype at TNFA -308 were associated with a 1.95-fold (95%CI: 1.16-3.28, p(corrected)=0.024) and 2.28-fold (95%CI: 1.30-4.00, p(corrected)=0.008) increased risk of cancer as compared to those with A allele or A/A+A/G genotypes, respectively. In addition, G allele (p=0.080) and G/G genotype (p=0.076) at TNFA -238 were associated with a borderline but statistically significant increased risk of OPSCC. The combined G/G+G/G genotype at both loci had a 2.37-fold increased risk of OPSCC as compared to those with other combined genotypes (95%CI: 1.41-4.00, p=0.001). Interactions between combined genotypes and smoking status were also found to contribute to risk of BQ-related OPSCC. There was no association of TNFA genotypes with clinicopathologic findings or the survival of OPSCC patients. CONCLUSIONS: BQ-chewers who carry the G allele or G/G genotype in TNFA -308 may have an increased risk of OPSCC. The intensity of cigarette smoking modulates the effect of the combined TNFA genotypes on risk of BQ-related OPSCC. SN - 1879-1506 UR - https://www.unboundmedicine.com/medline/citation/21497332/Interaction_between_tumour_necrosis_factor_α_gene_polymorphisms_and_substance_use_on_risk_of_betel_quid_related_oral_and_pharyngeal_squamous_cell_carcinoma_in_Taiwan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0003-9969(11)00089-6 DB - PRIME DP - Unbound Medicine ER -