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Depression and anxiety in a Portuguese MS population: associations with physical disability and severity of disease.
J Neurol Sci 2011; 306(1-2):66-70JN

Abstract

BACKGROUND

Mood disorders, namely depression and anxiety, have been well documented in patients with Multiple Sclerosis (MS). However, the putative associations between clinical features and mood disorders have not been well established.

OBJECTIVES

To detect anxiety and depression in MS patients; and to investigate possible associations with clinical factors.

SUBJECTS AND METHODS

325 consecutive patients with MS and 183 healthy subjects answered the Hospital Anxiety and Depression Scale (HADS), a self-rating questionnaire. Multiple Regression Analysis and Multivariate Analysis of Covariance were applied to assess the effect of demographic and clinical factors on HADS' anxiety and depression scores, using age and disease duration as covariates. Logistic Regression Analysis was used to study the influence of these factors on anxiety and depression, as defined by two different cut-off scores (i.e., 8 and 11).

RESULTS

Levels of anxiety and depression were significantly higher (p<0.001) for MS patients group than healthy subjects. Age, disease duration, age at onset, Kurtzke Expanded Disability Status Scale, and Multiple Sclerosis Severity Scale were positively associated with depression scores. Low education (i.e., <9 years) in MS was significantly associated with more anxiety and depression symptoms.

CONCLUSIONS

The study findings support a close linkage between depressive mood and physical manifestations of MS.

Authors+Show Affiliations

Neurology Department, Centro Hospitalar do Porto-Hospital de S. António (CHP-HSA), Porto, Portugal. anadmsilva@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21497358

Citation

da Silva, Ana Martins, et al. "Depression and Anxiety in a Portuguese MS Population: Associations With Physical Disability and Severity of Disease." Journal of the Neurological Sciences, vol. 306, no. 1-2, 2011, pp. 66-70.
da Silva AM, Vilhena E, Lopes A, et al. Depression and anxiety in a Portuguese MS population: associations with physical disability and severity of disease. J Neurol Sci. 2011;306(1-2):66-70.
da Silva, A. M., Vilhena, E., Lopes, A., Santos, E., Gonçalves, M. A., Pinto, C., ... Cavaco, S. (2011). Depression and anxiety in a Portuguese MS population: associations with physical disability and severity of disease. Journal of the Neurological Sciences, 306(1-2), pp. 66-70. doi:10.1016/j.jns.2011.03.042.
da Silva AM, et al. Depression and Anxiety in a Portuguese MS Population: Associations With Physical Disability and Severity of Disease. J Neurol Sci. 2011 Jul 15;306(1-2):66-70. PubMed PMID: 21497358.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Depression and anxiety in a Portuguese MS population: associations with physical disability and severity of disease. AU - da Silva,Ana Martins, AU - Vilhena,Estela, AU - Lopes,Alice, AU - Santos,Ernestina, AU - Gonçalves,Maria Alexandra, AU - Pinto,Cláudia, AU - Moreira,Inês, AU - Mendonça,Denisa, AU - Cavaco,Sara, Y1 - 2011/04/15/ PY - 2011/02/04/received PY - 2011/03/24/revised PY - 2011/03/28/accepted PY - 2011/4/19/entrez PY - 2011/4/19/pubmed PY - 2011/10/14/medline SP - 66 EP - 70 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 306 IS - 1-2 N2 - BACKGROUND: Mood disorders, namely depression and anxiety, have been well documented in patients with Multiple Sclerosis (MS). However, the putative associations between clinical features and mood disorders have not been well established. OBJECTIVES: To detect anxiety and depression in MS patients; and to investigate possible associations with clinical factors. SUBJECTS AND METHODS: 325 consecutive patients with MS and 183 healthy subjects answered the Hospital Anxiety and Depression Scale (HADS), a self-rating questionnaire. Multiple Regression Analysis and Multivariate Analysis of Covariance were applied to assess the effect of demographic and clinical factors on HADS' anxiety and depression scores, using age and disease duration as covariates. Logistic Regression Analysis was used to study the influence of these factors on anxiety and depression, as defined by two different cut-off scores (i.e., 8 and 11). RESULTS: Levels of anxiety and depression were significantly higher (p<0.001) for MS patients group than healthy subjects. Age, disease duration, age at onset, Kurtzke Expanded Disability Status Scale, and Multiple Sclerosis Severity Scale were positively associated with depression scores. Low education (i.e., <9 years) in MS was significantly associated with more anxiety and depression symptoms. CONCLUSIONS: The study findings support a close linkage between depressive mood and physical manifestations of MS. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/21497358/Depression_and_anxiety_in_a_Portuguese_MS_population:_associations_with_physical_disability_and_severity_of_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(11)00175-4 DB - PRIME DP - Unbound Medicine ER -