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Radial die-wall pressure as a reliable tool for studying the effect of powder water activity on high speed tableting.
Int J Pharm. 2011 Jun 15; 411(1-2):152-61.IJ

Abstract

The effect of moisture as a function of water activity (Aw) on the compaction process is important to understand particle/water interaction and deformation. Studying powder/moisture interaction under pressure with radial die-wall pressure (RDWP) tool was never done. The aim of our study was to use this tool to study this interaction at high compression pressure and speed. Moreover, the effect of changing ejection cam angle (EA) of the machine on ejection force (EF) was investigated. Also, a new tool for prediction of tablet sticking was proposed. Materials with different deformation behaviors stored at low and high moisture conditions were used. Compaction simulation guided by modeling was applied. High Aw resulted in a low residual die-wall pressure (RDP) for all materials, and a high maximum die-wall pressure (MDP) for plastic materials, p < 0.05. This was due to the lubricating and plasticizing effects of water, respectively. However, microcrystalline cellulose showed capping at high Aw and compaction pressure. By increasing compression pressure at high Aw for all materials, effective fall time (EFT) was increased, p < 0.05, showing tendency for sticking. Increasing EA caused an increase of friction and EF for powders, p < 0.05. RDWP was a useful tool to understand particle/moisture interaction under pressure.

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Authors+Show Affiliations

Abdel-Hamid S
Industrial Pharmacy Research Group, Department of Pharmaceutical Sciences, University of Basel, Mülhauserstr 51, CH-4056 Basel, Switzerland.
Betz G
No affiliation info available

MeSH

Calorimetry, Differential ScanningCelluloseCompressive StrengthDrug CompoundingEquipment and SuppliesExcipientsHumidityParticle SizePharmaceutical PreparationsPorosityPowdersPressureTabletsTensile StrengthWater

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21497644

Citation

Abdel-Hamid, Sameh, and Gabriele Betz. "Radial Die-wall Pressure as a Reliable Tool for Studying the Effect of Powder Water Activity On High Speed Tableting." International Journal of Pharmaceutics, vol. 411, no. 1-2, 2011, pp. 152-61.
Abdel-Hamid S, Betz G. Radial die-wall pressure as a reliable tool for studying the effect of powder water activity on high speed tableting. Int J Pharm. 2011;411(1-2):152-61.
Abdel-Hamid, S., & Betz, G. (2011). Radial die-wall pressure as a reliable tool for studying the effect of powder water activity on high speed tableting. International Journal of Pharmaceutics, 411(1-2), 152-61. https://doi.org/10.1016/j.ijpharm.2011.03.066
Abdel-Hamid S, Betz G. Radial Die-wall Pressure as a Reliable Tool for Studying the Effect of Powder Water Activity On High Speed Tableting. Int J Pharm. 2011 Jun 15;411(1-2):152-61. PubMed PMID: 21497644.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Radial die-wall pressure as a reliable tool for studying the effect of powder water activity on high speed tableting. AU - Abdel-Hamid,Sameh, AU - Betz,Gabriele, Y1 - 2011/04/08/ PY - 2011/01/31/received PY - 2011/03/25/revised PY - 2011/03/31/accepted PY - 2011/4/19/entrez PY - 2011/4/19/pubmed PY - 2012/1/11/medline SP - 152 EP - 61 JF - International journal of pharmaceutics JO - Int J Pharm VL - 411 IS - 1-2 N2 - The effect of moisture as a function of water activity (Aw) on the compaction process is important to understand particle/water interaction and deformation. Studying powder/moisture interaction under pressure with radial die-wall pressure (RDWP) tool was never done. The aim of our study was to use this tool to study this interaction at high compression pressure and speed. Moreover, the effect of changing ejection cam angle (EA) of the machine on ejection force (EF) was investigated. Also, a new tool for prediction of tablet sticking was proposed. Materials with different deformation behaviors stored at low and high moisture conditions were used. Compaction simulation guided by modeling was applied. High Aw resulted in a low residual die-wall pressure (RDP) for all materials, and a high maximum die-wall pressure (MDP) for plastic materials, p < 0.05. This was due to the lubricating and plasticizing effects of water, respectively. However, microcrystalline cellulose showed capping at high Aw and compaction pressure. By increasing compression pressure at high Aw for all materials, effective fall time (EFT) was increased, p < 0.05, showing tendency for sticking. Increasing EA caused an increase of friction and EF for powders, p < 0.05. RDWP was a useful tool to understand particle/moisture interaction under pressure. SN - 1873-3476 UR - https://www.unboundmedicine.com/medline/citation/21497644/Radial_die_wall_pressure_as_a_reliable_tool_for_studying_the_effect_of_powder_water_activity_on_high_speed_tableting_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5173(11)00302-4 DB - PRIME DP - Unbound Medicine ER -