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Dietary intake of metals and risk of Parkinson's disease: a case-control study in Japan.
J Neurol Sci. 2011 Jul 15; 306(1-2):98-102.JN

Abstract

Metals are involved in several important functions in the nervous system. Zinc and iron are increased and copper is decreased in the substantia nigra in Parkinson's disease (PD). However, epidemiological evidence for the association of dietary intake of metals with the risk of PD is limited. We investigated the relationship between metal consumption and the risk of PD in Japan using data from a multicenter hospital-based case-control study. Included were 249 cases within 6 years of onset of PD based on the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a self-administered diet history questionnaire. Higher intake of iron, magnesium, and zinc was independently associated with a reduced risk of PD: the adjusted OR in the highest quartile was 0.24 (95% CI: 0.10-0.57, P for trend=0.0003) for iron, 0.33 (95% CI: 0.13-0.81, P for trend=0.007) for magnesium and 0.50 (95% CI: 0.26-0.95, P for trend=0.055) for zinc. There were no relationships between the intake of copper or manganese and the risk of PD. Higher intake of iron, magnesium, and zinc may be protective against PD.

Authors+Show Affiliations

Department of Public Health, Faculty of Medicine, Fukuoka University, Fukuoka, Japan. miyake-y@fukuoka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21497832

Citation

Miyake, Yoshihiro, et al. "Dietary Intake of Metals and Risk of Parkinson's Disease: a Case-control Study in Japan." Journal of the Neurological Sciences, vol. 306, no. 1-2, 2011, pp. 98-102.
Miyake Y, Tanaka K, Fukushima W, et al. Dietary intake of metals and risk of Parkinson's disease: a case-control study in Japan. J Neurol Sci. 2011;306(1-2):98-102.
Miyake, Y., Tanaka, K., Fukushima, W., Sasaki, S., Kiyohara, C., Tsuboi, Y., Yamada, T., Oeda, T., Miki, T., Kawamura, N., Sakae, N., Fukuyama, H., Hirota, Y., & Nagai, M. (2011). Dietary intake of metals and risk of Parkinson's disease: a case-control study in Japan. Journal of the Neurological Sciences, 306(1-2), 98-102. https://doi.org/10.1016/j.jns.2011.03.035
Miyake Y, et al. Dietary Intake of Metals and Risk of Parkinson's Disease: a Case-control Study in Japan. J Neurol Sci. 2011 Jul 15;306(1-2):98-102. PubMed PMID: 21497832.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary intake of metals and risk of Parkinson's disease: a case-control study in Japan. AU - Miyake,Yoshihiro, AU - Tanaka,Keiko, AU - Fukushima,Wakaba, AU - Sasaki,Satoshi, AU - Kiyohara,Chikako, AU - Tsuboi,Yoshio, AU - Yamada,Tatsuo, AU - Oeda,Tomoko, AU - Miki,Takami, AU - Kawamura,Nobutoshi, AU - Sakae,Nobutaka, AU - Fukuyama,Hidenao, AU - Hirota,Yoshio, AU - Nagai,Masaki, AU - ,, Y1 - 2011/04/16/ PY - 2011/01/28/received PY - 2011/03/15/revised PY - 2011/03/18/accepted PY - 2011/4/19/entrez PY - 2011/4/19/pubmed PY - 2011/10/14/medline SP - 98 EP - 102 JF - Journal of the neurological sciences JO - J Neurol Sci VL - 306 IS - 1-2 N2 - Metals are involved in several important functions in the nervous system. Zinc and iron are increased and copper is decreased in the substantia nigra in Parkinson's disease (PD). However, epidemiological evidence for the association of dietary intake of metals with the risk of PD is limited. We investigated the relationship between metal consumption and the risk of PD in Japan using data from a multicenter hospital-based case-control study. Included were 249 cases within 6 years of onset of PD based on the UK PD Society Brain Bank clinical diagnostic criteria. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Information on dietary factors was collected using a self-administered diet history questionnaire. Higher intake of iron, magnesium, and zinc was independently associated with a reduced risk of PD: the adjusted OR in the highest quartile was 0.24 (95% CI: 0.10-0.57, P for trend=0.0003) for iron, 0.33 (95% CI: 0.13-0.81, P for trend=0.007) for magnesium and 0.50 (95% CI: 0.26-0.95, P for trend=0.055) for zinc. There were no relationships between the intake of copper or manganese and the risk of PD. Higher intake of iron, magnesium, and zinc may be protective against PD. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/21497832/Dietary_intake_of_metals_and_risk_of_Parkinson's_disease:_a_case_control_study_in_Japan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(11)00165-1 DB - PRIME DP - Unbound Medicine ER -