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Normal fasting plasma glucose and risk of type 2 diabetes.
Diabetes Care. 2011 Jun; 34(6):1372-4.DC

Abstract

OBJECTIVE

To investigate the association of normal fasting plasma glucose (FPG) and the risk for type 2 diabetes.

RESEARCH DESIGN AND METHODS

Data concerning 13,845 subjects, aged 40-69 years, who had their FPG measured at least three times between 1992 and 2008 were extracted from a database. Three FPG groups were defined (51-82, 83-90, and 91-99 mg/dL). A Cox proportional hazards analysis was applied to estimate the risk of incident diabetes adjusted for other risk factors.

RESULTS

During 108,061 person-years of follow-up (8,110 women and 5,735 men), 307 incident cases of type 2 diabetes were found. The final model demonstrated a hazard ratio of 2.03 (95% CI 1.18-3.50) for 91-99 mg/dL and 1.42 (0.42-4.74) for 83-90 mg/dL.

CONCLUSIONS

Our data suggest that FPG between 91 and 99 mg/dL is a strong independent predictor of type 2 diabetes and should be used to identify people to be further investigated and aided with preventive measures.

Authors+Show Affiliations

University Department of Laboratory Medicine, University Milano Bicocca, Hospital of Desio, Milano, Italy. paolo.brambilla@uds.unimib.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

21498787

Citation

Brambilla, Paolo, et al. "Normal Fasting Plasma Glucose and Risk of Type 2 Diabetes." Diabetes Care, vol. 34, no. 6, 2011, pp. 1372-4.
Brambilla P, La Valle E, Falbo R, et al. Normal fasting plasma glucose and risk of type 2 diabetes. Diabetes Care. 2011;34(6):1372-4.
Brambilla, P., La Valle, E., Falbo, R., Limonta, G., Signorini, S., Cappellini, F., & Mocarelli, P. (2011). Normal fasting plasma glucose and risk of type 2 diabetes. Diabetes Care, 34(6), 1372-4. https://doi.org/10.2337/dc10-2263
Brambilla P, et al. Normal Fasting Plasma Glucose and Risk of Type 2 Diabetes. Diabetes Care. 2011;34(6):1372-4. PubMed PMID: 21498787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Normal fasting plasma glucose and risk of type 2 diabetes. AU - Brambilla,Paolo, AU - La Valle,Elisa, AU - Falbo,Rosanna, AU - Limonta,Giuseppe, AU - Signorini,Stefano, AU - Cappellini,Fabrizio, AU - Mocarelli,Paolo, Y1 - 2011/04/15/ PY - 2011/4/19/entrez PY - 2011/4/19/pubmed PY - 2011/9/29/medline SP - 1372 EP - 4 JF - Diabetes care JO - Diabetes Care VL - 34 IS - 6 N2 - OBJECTIVE: To investigate the association of normal fasting plasma glucose (FPG) and the risk for type 2 diabetes. RESEARCH DESIGN AND METHODS: Data concerning 13,845 subjects, aged 40-69 years, who had their FPG measured at least three times between 1992 and 2008 were extracted from a database. Three FPG groups were defined (51-82, 83-90, and 91-99 mg/dL). A Cox proportional hazards analysis was applied to estimate the risk of incident diabetes adjusted for other risk factors. RESULTS: During 108,061 person-years of follow-up (8,110 women and 5,735 men), 307 incident cases of type 2 diabetes were found. The final model demonstrated a hazard ratio of 2.03 (95% CI 1.18-3.50) for 91-99 mg/dL and 1.42 (0.42-4.74) for 83-90 mg/dL. CONCLUSIONS: Our data suggest that FPG between 91 and 99 mg/dL is a strong independent predictor of type 2 diabetes and should be used to identify people to be further investigated and aided with preventive measures. SN - 1935-5548 UR - https://www.unboundmedicine.com/medline/citation/21498787/Normal_fasting_plasma_glucose_and_risk_of_type_2_diabetes_ L2 - http://care.diabetesjournals.org/cgi/pmidlookup?view=long&pmid=21498787 DB - PRIME DP - Unbound Medicine ER -