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Effects of desogestrel and gestodene in low-dose oral contraceptive combinations on lipid and lipoprotein status. A randomized prospective study.
Acta Eur Fertil 1990 May-Jun; 21(3):143-6AE

Abstract

This study was designated to assess the effects of two low-dose oral contraceptives (OC) on serum lipids and lipoproteins and to compare, at same oestrogen dose (30 micrograms), the effects of desogestrel (DG) with those of a new progestin, gestodene (GD). Fifty-four young women, matched for Quetelet's Index, age, diet, alcohol consumption, smoking and exercise habits, were randomly assigned to one of two regimens. Serum high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, total triglycerides (T) and cholesterol (C), apolipoprotein A-1 (Apo A) and apolipoprotein B (Apo B) were measured prior to the OC commencement and after 6-cycle treatment. Sex hormone binding globulin (SHRG) and ceruloplasmin (CP) were determined as well. LDL-C, Apo A, C, T, increased significantly from baseline values, being still the increase within the reference range. Apo B changed proportional to the LDL-C increase. A rise in HDL-C occurred but it was statistically significant in the EE-DG group only. This result would suggest that the EE-DG combination is more estrogen-dominant that the EE-GD combination. However, this hypothesis was not consistent with the increase to the similar extent for SHBG and CP, which reflect the estrogenicity/gestagenicity of the two OCs. The disproportion of change between HDL-C and Apo A in only EE-GD group might reflect some compositional change in HDL particle. There were no significant differences between the two formulations for the parameters investigated.

Authors+Show Affiliations

Institute of Clinica Medica I, University of Messina, School of Medicine, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

2149913

Citation

Granata, A, et al. "Effects of Desogestrel and Gestodene in Low-dose Oral Contraceptive Combinations On Lipid and Lipoprotein Status. a Randomized Prospective Study." Acta Europaea Fertilitatis, vol. 21, no. 3, 1990, pp. 143-6.
Granata A, Sobbrio GA, D'Arrigo F, et al. Effects of desogestrel and gestodene in low-dose oral contraceptive combinations on lipid and lipoprotein status. A randomized prospective study. Acta Eur Fertil. 1990;21(3):143-6.
Granata, A., Sobbrio, G. A., D'Arrigo, F., Barillari, M., Curasì, M. P., Egitto, M., ... Pullè, C. (1990). Effects of desogestrel and gestodene in low-dose oral contraceptive combinations on lipid and lipoprotein status. A randomized prospective study. Acta Europaea Fertilitatis, 21(3), pp. 143-6.
Granata A, et al. Effects of Desogestrel and Gestodene in Low-dose Oral Contraceptive Combinations On Lipid and Lipoprotein Status. a Randomized Prospective Study. Acta Eur Fertil. 1990;21(3):143-6. PubMed PMID: 2149913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of desogestrel and gestodene in low-dose oral contraceptive combinations on lipid and lipoprotein status. A randomized prospective study. AU - Granata,A, AU - Sobbrio,G A, AU - D'Arrigo,F, AU - Barillari,M, AU - Curasì,M P, AU - Egitto,M, AU - Trimarchi,F, AU - Granese,D, AU - Pullè,C, PY - 1990/5/1/pubmed PY - 1990/5/1/medline PY - 1990/5/1/entrez KW - Arterial Occlusive Diseases KW - Arteriosclerosis KW - Atherosclerosis--etiology KW - Biology KW - Cardiovascular Effects KW - Cholesterol KW - Comparative Studies KW - Contraception KW - Contraceptive Agents KW - Contraceptive Agents, Estrogen KW - Contraceptive Agents, Female KW - Contraceptive Agents, Progestin KW - Contraceptive Methods KW - Desogestrel KW - Diseases KW - Ethinyl Estradiol KW - Examinations And Diagnoses KW - Family Planning KW - Gestodene KW - Laboratory Examinations And Diagnoses KW - Lipid Metabolic Effects--analysis KW - Lipids KW - Oral Contraceptives KW - Oral Contraceptives, Low-dose KW - Physiology KW - Prospective Studies KW - Research Methodology KW - Research Report KW - Studies KW - Vascular Diseases SP - 143 EP - 6 JF - Acta Europaea fertilitatis JO - Acta Eur. Fertil. VL - 21 IS - 3 N2 - This study was designated to assess the effects of two low-dose oral contraceptives (OC) on serum lipids and lipoproteins and to compare, at same oestrogen dose (30 micrograms), the effects of desogestrel (DG) with those of a new progestin, gestodene (GD). Fifty-four young women, matched for Quetelet's Index, age, diet, alcohol consumption, smoking and exercise habits, were randomly assigned to one of two regimens. Serum high-density lipoprotein (HDL) cholesterol, low-density lipoprotein (LDL) cholesterol, total triglycerides (T) and cholesterol (C), apolipoprotein A-1 (Apo A) and apolipoprotein B (Apo B) were measured prior to the OC commencement and after 6-cycle treatment. Sex hormone binding globulin (SHRG) and ceruloplasmin (CP) were determined as well. LDL-C, Apo A, C, T, increased significantly from baseline values, being still the increase within the reference range. Apo B changed proportional to the LDL-C increase. A rise in HDL-C occurred but it was statistically significant in the EE-DG group only. This result would suggest that the EE-DG combination is more estrogen-dominant that the EE-GD combination. However, this hypothesis was not consistent with the increase to the similar extent for SHBG and CP, which reflect the estrogenicity/gestagenicity of the two OCs. The disproportion of change between HDL-C and Apo A in only EE-GD group might reflect some compositional change in HDL particle. There were no significant differences between the two formulations for the parameters investigated. SN - 0587-2421 UR - https://www.unboundmedicine.com/medline/citation/2149913/Effects_of_desogestrel_and_gestodene_in_low_dose_oral_contraceptive_combinations_on_lipid_and_lipoprotein_status__A_randomized_prospective_study_ DB - PRIME DP - Unbound Medicine ER -