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Pharmacognostic and acute toxicological evaluation of Scaptotrigona aff. postica propolis extract in pre-clinical assays.
Nat Prod Res 2011; 25(11):1037-46NP

Abstract

The propolis of Scaptotrigona aff. postica is popularly used in Maranhão State, Brazil, for treating wounds and respiratory illnesses. Nevertheless, little is known about the chemical composition of this propolis and the adverse effects of its use. Hence, this study is a pharmacognostic characterisation of the propolis hydroalcoholic extract (PHE) from S. aff. postica. The methodology consisted of an evaluation of the sensory and chemical parameters. Chemical analysis of PHE indicated high concentrations of phenolic and triterpens substances, and the absence of steroids. Additionally, we evaluated the acute toxicity of propolis using 48 Swiss male and female mice. The animals received single doses of PHE (1000, 2000 or 4000 mg kg⁻¹) orally and were observed for 14 days. After this period, the mice were sacrificed and the blood was used for biochemical and haematological evaluation. PHE did not induce any death, and the acute treatment significantly reduced serum concentrations of alanine aminotransferase and alkaline phosphatase. The resultant data indicate that PHE from S. aff. postica has low toxicity when used orally, even in high doses.

Authors+Show Affiliations

Laboratory of Immunophysiology, Healthy and Biological Sciences Centre, Federal University of Maranhão, São Luís, MA 65085-580, Brazil.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

21500093

Citation

Araújo, M J A M., et al. "Pharmacognostic and Acute Toxicological Evaluation of Scaptotrigona Aff. Postica Propolis Extract in Pre-clinical Assays." Natural Product Research, vol. 25, no. 11, 2011, pp. 1037-46.
Araújo MJ, Mattar NS, Reis AS, et al. Pharmacognostic and acute toxicological evaluation of Scaptotrigona aff. postica propolis extract in pre-clinical assays. Nat Prod Res. 2011;25(11):1037-46.
Araújo, M. J., Mattar, N. S., Reis, A. S., Serra, I. C., Fialho, E. M., Assunção, A. K., ... Nascimento, F. R. (2011). Pharmacognostic and acute toxicological evaluation of Scaptotrigona aff. postica propolis extract in pre-clinical assays. Natural Product Research, 25(11), pp. 1037-46. doi:10.1080/14786419.2010.482059.
Araújo MJ, et al. Pharmacognostic and Acute Toxicological Evaluation of Scaptotrigona Aff. Postica Propolis Extract in Pre-clinical Assays. Nat Prod Res. 2011;25(11):1037-46. PubMed PMID: 21500093.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pharmacognostic and acute toxicological evaluation of Scaptotrigona aff. postica propolis extract in pre-clinical assays. AU - Araújo,M J A M, AU - Mattar,N S, AU - Reis,A S, AU - Serra,I C P B, AU - Fialho,E M S, AU - Assunção,A K M, AU - Dutra,R P, AU - Nogueira,A M C, AU - Libério,S A, AU - Guerra,R N M, AU - Lopes,A S, AU - Ribeiro,M N S, AU - Nascimento,F R F, PY - 2011/4/19/entrez PY - 2011/4/19/pubmed PY - 2011/12/13/medline SP - 1037 EP - 46 JF - Natural product research JO - Nat. Prod. Res. VL - 25 IS - 11 N2 - The propolis of Scaptotrigona aff. postica is popularly used in Maranhão State, Brazil, for treating wounds and respiratory illnesses. Nevertheless, little is known about the chemical composition of this propolis and the adverse effects of its use. Hence, this study is a pharmacognostic characterisation of the propolis hydroalcoholic extract (PHE) from S. aff. postica. The methodology consisted of an evaluation of the sensory and chemical parameters. Chemical analysis of PHE indicated high concentrations of phenolic and triterpens substances, and the absence of steroids. Additionally, we evaluated the acute toxicity of propolis using 48 Swiss male and female mice. The animals received single doses of PHE (1000, 2000 or 4000 mg kg⁻¹) orally and were observed for 14 days. After this period, the mice were sacrificed and the blood was used for biochemical and haematological evaluation. PHE did not induce any death, and the acute treatment significantly reduced serum concentrations of alanine aminotransferase and alkaline phosphatase. The resultant data indicate that PHE from S. aff. postica has low toxicity when used orally, even in high doses. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/21500093/full_citation/Pharmacognostic_and_acute_toxicological_evaluation_of_Scaptotrigona_aff__postica_propolis_extract_in_pre_clinical_assays_ L2 - http://www.tandfonline.com/doi/full/10.1080/14786419.2010.482059 DB - PRIME DP - Unbound Medicine ER -