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Pharmacognostic and acute toxicological evaluation of Scaptotrigona aff. postica propolis extract in pre-clinical assays.

Abstract

The propolis of Scaptotrigona aff. postica is popularly used in Maranhão State, Brazil, for treating wounds and respiratory illnesses. Nevertheless, little is known about the chemical composition of this propolis and the adverse effects of its use. Hence, this study is a pharmacognostic characterisation of the propolis hydroalcoholic extract (PHE) from S. aff. postica. The methodology consisted of an evaluation of the sensory and chemical parameters. Chemical analysis of PHE indicated high concentrations of phenolic and triterpens substances, and the absence of steroids. Additionally, we evaluated the acute toxicity of propolis using 48 Swiss male and female mice. The animals received single doses of PHE (1000, 2000 or 4000 mg kg⁻¹) orally and were observed for 14 days. After this period, the mice were sacrificed and the blood was used for biochemical and haematological evaluation. PHE did not induce any death, and the acute treatment significantly reduced serum concentrations of alanine aminotransferase and alkaline phosphatase. The resultant data indicate that PHE from S. aff. postica has low toxicity when used orally, even in high doses.

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  • Authors

    , , , , , , , , , , , ,

    Source

    Natural product research 25:11 2011 Jul pg 1037-46

    MeSH

    Alanine Transaminase
    Alkaline Phosphatase
    Animals
    Bees
    Enzyme Activation
    Female
    Male
    Mice
    Propolis
    Toxicity Tests, Acute

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    21500093

    Citation

    TY - JOUR T1 - Pharmacognostic and acute toxicological evaluation of Scaptotrigona aff. postica propolis extract in pre-clinical assays. AU - Araújo,M J A M, AU - Mattar,N S, AU - Reis,A S, AU - Serra,I C P B, AU - Fialho,E M S, AU - Assunção,A K M, AU - Dutra,R P, AU - Nogueira,A M C, AU - Libério,S A, AU - Guerra,R N M, AU - Lopes,A S, AU - Ribeiro,M N S, AU - Nascimento,F R F, PY - 2011/4/19/entrez PY - 2011/4/19/pubmed PY - 2011/12/13/medline SP - 1037 EP - 46 JF - Natural product research JO - Nat. Prod. Res. VL - 25 IS - 11 N2 - The propolis of Scaptotrigona aff. postica is popularly used in Maranhão State, Brazil, for treating wounds and respiratory illnesses. Nevertheless, little is known about the chemical composition of this propolis and the adverse effects of its use. Hence, this study is a pharmacognostic characterisation of the propolis hydroalcoholic extract (PHE) from S. aff. postica. The methodology consisted of an evaluation of the sensory and chemical parameters. Chemical analysis of PHE indicated high concentrations of phenolic and triterpens substances, and the absence of steroids. Additionally, we evaluated the acute toxicity of propolis using 48 Swiss male and female mice. The animals received single doses of PHE (1000, 2000 or 4000 mg kg⁻¹) orally and were observed for 14 days. After this period, the mice were sacrificed and the blood was used for biochemical and haematological evaluation. PHE did not induce any death, and the acute treatment significantly reduced serum concentrations of alanine aminotransferase and alkaline phosphatase. The resultant data indicate that PHE from S. aff. postica has low toxicity when used orally, even in high doses. SN - 1478-6427 UR - https://www.unboundmedicine.com/medline/citation/21500093/full_citation/Pharmacognostic_and_acute_toxicological_evaluation_of_Scaptotrigona_aff__postica_propolis_extract_in_pre_clinical_assays_ L2 - http://www.tandfonline.com/doi/abs/10.1080/14786419.2010.482059?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed ER -