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Efficacy of gabapentin on subjective idiopathic tinnitus: a randomized, double-blind, placebo-controlled trial.
Ear Nose Throat J. 2011 Apr; 90(4):150-8.EN

Abstract

Tinnitus can cause extreme morbidity. Despite many attempts to find a treatment for idiopathic cases, they remain difficult to manage. Because nerve injury is one of the suspected etiologies of tinnitus and because gabapentin has been found to be effective in treating nerve injuries, some authors have attempted to determine if gabapentin has a role in treating tinnitus. Although gabapentin was found to be ineffective for tinnitus in these previous studies, to the best of our knowledge no studies have been performed that took into consideration the presence of various accompanying factors and concomitant diseases that might influence its effect. We conducted a prospective, randomized, double-blind, placebo-controlled clinical trial of gabapentin for idiopathic tinnitus. We treated 40 patients with gabapentin and measured its effectiveness by comparing differences between pre- and post-treatment Tinnitus Severity Index (TSI) values and tinnitus loudness scores. We also compared these outcomes with those of a group of 40 matched placebo controls. At study's end, we found no significant differences between the gabapentin and control groups in mean decreases in TSI value and loudness score (p=0.85 and p=0.12, respectively). However, we did find that patients with hypertension, diabetes, and/or dyslipidemia showed a better response to gabapentin than did those with tinnitus alone (p=0.01). We conclude that although there was no statistically significant difference between gabapentin and placebo in treating isolated tinnitus or tinnitus overall, patients with concomitant hypertension, diabetes, and/or dyslipidemia may benefit from gabapentin.

Authors+Show Affiliations

The Department of Otolaryngology, Islamic Azad University, Mashhad Branch, Mashhad, Iran.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

21500166

Citation

Dehkordi, Mahboobeh Adami, et al. "Efficacy of Gabapentin On Subjective Idiopathic Tinnitus: a Randomized, Double-blind, Placebo-controlled Trial." Ear, Nose, & Throat Journal, vol. 90, no. 4, 2011, pp. 150-8.
Dehkordi MA, Abolbashari S, Taheri R, et al. Efficacy of gabapentin on subjective idiopathic tinnitus: a randomized, double-blind, placebo-controlled trial. Ear Nose Throat J. 2011;90(4):150-8.
Dehkordi, M. A., Abolbashari, S., Taheri, R., & Einolghozati, S. (2011). Efficacy of gabapentin on subjective idiopathic tinnitus: a randomized, double-blind, placebo-controlled trial. Ear, Nose, & Throat Journal, 90(4), 150-8.
Dehkordi MA, et al. Efficacy of Gabapentin On Subjective Idiopathic Tinnitus: a Randomized, Double-blind, Placebo-controlled Trial. Ear Nose Throat J. 2011;90(4):150-8. PubMed PMID: 21500166.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Efficacy of gabapentin on subjective idiopathic tinnitus: a randomized, double-blind, placebo-controlled trial. AU - Dehkordi,Mahboobeh Adami, AU - Abolbashari,Samaneh, AU - Taheri,Reza, AU - Einolghozati,Sasan, PY - 2011/4/19/entrez PY - 2011/4/19/pubmed PY - 2011/10/15/medline SP - 150 EP - 8 JF - Ear, nose, & throat journal JO - Ear Nose Throat J VL - 90 IS - 4 N2 - Tinnitus can cause extreme morbidity. Despite many attempts to find a treatment for idiopathic cases, they remain difficult to manage. Because nerve injury is one of the suspected etiologies of tinnitus and because gabapentin has been found to be effective in treating nerve injuries, some authors have attempted to determine if gabapentin has a role in treating tinnitus. Although gabapentin was found to be ineffective for tinnitus in these previous studies, to the best of our knowledge no studies have been performed that took into consideration the presence of various accompanying factors and concomitant diseases that might influence its effect. We conducted a prospective, randomized, double-blind, placebo-controlled clinical trial of gabapentin for idiopathic tinnitus. We treated 40 patients with gabapentin and measured its effectiveness by comparing differences between pre- and post-treatment Tinnitus Severity Index (TSI) values and tinnitus loudness scores. We also compared these outcomes with those of a group of 40 matched placebo controls. At study's end, we found no significant differences between the gabapentin and control groups in mean decreases in TSI value and loudness score (p=0.85 and p=0.12, respectively). However, we did find that patients with hypertension, diabetes, and/or dyslipidemia showed a better response to gabapentin than did those with tinnitus alone (p=0.01). We conclude that although there was no statistically significant difference between gabapentin and placebo in treating isolated tinnitus or tinnitus overall, patients with concomitant hypertension, diabetes, and/or dyslipidemia may benefit from gabapentin. SN - 1942-7522 UR - https://www.unboundmedicine.com/medline/citation/21500166/Efficacy_of_gabapentin_on_subjective_idiopathic_tinnitus:_a_randomized_double_blind_placebo_controlled_trial_ L2 - http://journals.sagepub.com/doi/full/10.1177/014556131109000405?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -