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[The immunopathology mechanisms of matrix metalloproteinases in brain infection induced by parasites].

Abstract

Matrix metalloproteinase (MMP) family is a class of endogenous peptidases involved in normal physiological processes of the body, such as embryonic development, wound healing, angiogenesis, cartilage absorption, etc. However, during infection, over-expression of activated matrix metalloproteinase can lead to immunopathological change, induce disease or death, also contribute to the spread or survival of pathogens. Some human parasites such as Plasmodium, Toxoplasma gondii, Cysticercus cellulose, Angiostrongylus cantonensis larvae can invade the central nervous system, and cause inflammatory response dominated by eosinophil infiltration. This article reviews function and pathological mechanism of MMP during the infection of relevant parasites involving brain.

Authors+Show Affiliations

Department of Parasitology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou 510080, China.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

chi

PubMed ID

21500539

Citation

Sun, Rui, and Zhong-Dao Wu. "[The Immunopathology Mechanisms of Matrix Metalloproteinases in Brain Infection Induced By Parasites]." Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi = Chinese Journal of Parasitology & Parasitic Diseases, vol. 28, no. 6, 2010, pp. 468-73.
Sun R, Wu ZD. [The immunopathology mechanisms of matrix metalloproteinases in brain infection induced by parasites]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2010;28(6):468-73.
Sun, R., & Wu, Z. D. (2010). [The immunopathology mechanisms of matrix metalloproteinases in brain infection induced by parasites]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi = Chinese Journal of Parasitology & Parasitic Diseases, 28(6), pp. 468-73.
Sun R, Wu ZD. [The Immunopathology Mechanisms of Matrix Metalloproteinases in Brain Infection Induced By Parasites]. Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi. 2010 Dec 30;28(6):468-73. PubMed PMID: 21500539.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The immunopathology mechanisms of matrix metalloproteinases in brain infection induced by parasites]. AU - Sun,Rui, AU - Wu,Zhong-Dao, PY - 2011/4/20/entrez PY - 2011/4/20/pubmed PY - 2012/1/20/medline SP - 468 EP - 73 JF - Zhongguo ji sheng chong xue yu ji sheng chong bing za zhi = Chinese journal of parasitology & parasitic diseases JO - Zhongguo Ji Sheng Chong Xue Yu Ji Sheng Chong Bing Za Zhi VL - 28 IS - 6 N2 - Matrix metalloproteinase (MMP) family is a class of endogenous peptidases involved in normal physiological processes of the body, such as embryonic development, wound healing, angiogenesis, cartilage absorption, etc. However, during infection, over-expression of activated matrix metalloproteinase can lead to immunopathological change, induce disease or death, also contribute to the spread or survival of pathogens. Some human parasites such as Plasmodium, Toxoplasma gondii, Cysticercus cellulose, Angiostrongylus cantonensis larvae can invade the central nervous system, and cause inflammatory response dominated by eosinophil infiltration. This article reviews function and pathological mechanism of MMP during the infection of relevant parasites involving brain. SN - 1000-7423 UR - https://www.unboundmedicine.com/medline/citation/21500539/[The_immunopathology_mechanisms_of_matrix_metalloproteinases_in_brain_infection_induced_by_parasites]_ DB - PRIME DP - Unbound Medicine ER -