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Using quantitative magnetic resonance methods to understand better the gel-layer formation on polymer-matrix tablets.
Expert Opin Drug Deliv. 2011 May; 8(5):677-92.EO

Abstract

INTRODUCTION

Magnetic resonance imaging is a powerful, non-invasive technique that can help improve our understanding of the hydrogel layer formed on swellable, polymer-matrix tablets, as well as the layer's properties and its influence on drug release.

AREAS COVERED

In this paper, the authors review the NMR and MRI investigations of hydrophilic, swellable polymers published since 1994. The review covers NMR studies on the properties of water and drugs within hydrated polymers. In addition, MRI studies using techniques for determining the different moving-front positions within the swollen tablets, the polymer concentration profiles across them, the influence of the incorporated drug, and so on, are presented. Some complementary methods are also briefly presented and discussed.

EXPERT OPINION

Using MRI, the formation of a hydrogel along with simultaneous determination of the drug's position within it can be observed non-invasively. However, the MRI parameters can influence the signal's intensity and therefore they need to be considered carefully in order to prevent any misinterpretation of the results. MRI makes possible an in situ investigation of swollen-matrix tablets and provides valuable information that can lead, when combined with other techniques, to a better understanding of polymeric systems and a more effective development of optimal dosage forms.

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Publisher Full Text

Authors+Show Affiliations

Mikac U
Jožef Stefan Institute, Jamova 39, 1000 Ljubljana, Slovenia.
Kristl J
No affiliation info available
Baumgartner S
No affiliation info available

MeSH

Drug CarriersExcipientsGelsHumansMagnetic Resonance ImagingMagnetic Resonance SpectroscopyPolymersTablets

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Review

Language

eng

PubMed ID

21501097

Citation

Mikac, Urša, et al. "Using Quantitative Magnetic Resonance Methods to Understand Better the Gel-layer Formation On Polymer-matrix Tablets." Expert Opinion On Drug Delivery, vol. 8, no. 5, 2011, pp. 677-92.
Mikac U, Kristl J, Baumgartner S. Using quantitative magnetic resonance methods to understand better the gel-layer formation on polymer-matrix tablets. Expert Opin Drug Deliv. 2011;8(5):677-92.
Mikac, U., Kristl, J., & Baumgartner, S. (2011). Using quantitative magnetic resonance methods to understand better the gel-layer formation on polymer-matrix tablets. Expert Opinion On Drug Delivery, 8(5), 677-92. https://doi.org/10.1517/17425247.2011.566554
Mikac U, Kristl J, Baumgartner S. Using Quantitative Magnetic Resonance Methods to Understand Better the Gel-layer Formation On Polymer-matrix Tablets. Expert Opin Drug Deliv. 2011;8(5):677-92. PubMed PMID: 21501097.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Using quantitative magnetic resonance methods to understand better the gel-layer formation on polymer-matrix tablets. AU - Mikac,Urša, AU - Kristl,Julijana, AU - Baumgartner,Saša, Y1 - 2011/03/29/ PY - 2011/4/20/entrez PY - 2011/4/20/pubmed PY - 2011/12/15/medline SP - 677 EP - 92 JF - Expert opinion on drug delivery JO - Expert Opin Drug Deliv VL - 8 IS - 5 N2 - INTRODUCTION: Magnetic resonance imaging is a powerful, non-invasive technique that can help improve our understanding of the hydrogel layer formed on swellable, polymer-matrix tablets, as well as the layer's properties and its influence on drug release. AREAS COVERED: In this paper, the authors review the NMR and MRI investigations of hydrophilic, swellable polymers published since 1994. The review covers NMR studies on the properties of water and drugs within hydrated polymers. In addition, MRI studies using techniques for determining the different moving-front positions within the swollen tablets, the polymer concentration profiles across them, the influence of the incorporated drug, and so on, are presented. Some complementary methods are also briefly presented and discussed. EXPERT OPINION: Using MRI, the formation of a hydrogel along with simultaneous determination of the drug's position within it can be observed non-invasively. However, the MRI parameters can influence the signal's intensity and therefore they need to be considered carefully in order to prevent any misinterpretation of the results. MRI makes possible an in situ investigation of swollen-matrix tablets and provides valuable information that can lead, when combined with other techniques, to a better understanding of polymeric systems and a more effective development of optimal dosage forms. SN - 1744-7593 UR - https://www.unboundmedicine.com/medline/citation/21501097/Using_quantitative_magnetic_resonance_methods_to_understand_better_the_gel_layer_formation_on_polymer_matrix_tablets_ L2 - https://www.tandfonline.com/doi/full/10.1517/17425247.2011.566554 DB - PRIME DP - Unbound Medicine ER -